平野和也 (Kazuya Hirano) - マイポータル

基本情報

所属: 高崎健康福祉大学薬学部衛生化学研究室教授

学位: 博士(薬学)(東京大学)

J-GLOBAL ID: 200901085845632999
researchmap会員ID: 1000255227

外部リンク: http://www.takasaki-u.ac.jp/

研究キーワード

研究分野

経歴

2014年4月 - 現在

高崎健康福祉大学, 薬学部, 教授
2000年4月 - 2014年3月

東京薬科大学, 薬学部, 講師
1993年 - 2000年

東京大学大学院医学系研究科助手
1993年 - 2000年

University of Tokyo, Faculty of Medicine, Graduate School Medicine research assistant

学歴

- 1993年

東京大学, 薬学系研究科, 生命薬学
- 1993年

東京大学

論文

Nucleolin Is a Receptor for Maleylated-Bovine Serum Albumin on Macrophages

Yuichi Miki, Keisuke Koyama, Haruna Kurusu, Kazuya Hirano, Masatoshi Beppu, Yasuyuki Fujiwara

BIOLOGICAL & PHARMACEUTICAL BULLETIN 38(1) 116-121 2015年1月査読有り
Macrophage Recognition of Toxic Advanced Glycosylation End Products through the Macrophage Surface-Receptor Nucleolin

Yuichi Miki, Hikaru Dambara, Yoshihiro Tachibana, Kazuya Hirano, Mio Konishi, Masatoshi Beppu

BIOLOGICAL & PHARMACEUTICAL BULLETIN 37(4) 588-596 2014年4月査読有り
Shuttling Protein Nucleolin Is a Microglia Receptor for Amyloid Beta Peptide 1-42

Daisuke Ozawa, Takashi Nakamura, Masanori Koike, Kazuya Hirano, Yuichi Miki, Masatoshi Beppu

BIOLOGICAL & PHARMACEUTICAL BULLETIN 36(10) 1587-1593 2013年10月査読有り
Photodynamic therapy with talaporfin sodium induces dose-dependent apoptotic cell death in human glioma cell lines

Masateru Tsutsumi, Yuichi Miki, Jiro Akimoto, Jo Haraoka, Katsuo Aizawa, Kazuya Hirano, Masatoshi Beppu

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY 10(2) 103-110 2013年5月査読有り
Photodynamic Therapy in Combination with Talaporfin Sodium Induces Mitochondrial Apoptotic Cell Death Accompanied with Necrosis in Glioma Cells

Yuichi Miki, Jiro Akimoto, Sakino Yokoyama, Tomomi Homma, Masateru Tsutsumi, Jo Haraoka, Kazuya Hirano, Masatoshi Beppu

BIOLOGICAL & PHARMACEUTICAL BULLETIN 36(2) 215-221 2013年2月査読有り
Macrophage Recognition of Cells with Elevated Calcium Is Mediated by Carbohydrate Chains of CD43

Yuichi Miki, Emiri Oguri, Kazuya Hirano, Masatoshi Beppu

CELL STRUCTURE AND FUNCTION 38(1) 43-54 2013年査読有り
Macrophage Recognition of Thiol-Group Oxidized Cells: Recognition of Carbohydrate Chains by Macrophage Surface Nucleolin as Apoptotic Cells

Yuichi Miki, Kazuya Hirano, Masatoshi Beppu

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 76(11) 2068-2074 2012年11月査読有り
Clearance of CD43-Capped Cells by Macrophages: Capping Alone Leads to Phagocytosis

Emiri Oguri, Yuichi Miki, Kazuya Hirano, Masahiro Yamanaka, Masatoshi Beppu

BIOLOGICAL & PHARMACEUTICAL BULLETIN 35(4) 551-558 2012年4月査読有り
Nucleolin on the Cell Surface as a New Molecular Target for Gastric Cancer Treatment

Tatsuro Watanabe, Kazuya Hirano, Atsushi Takahashi, Kensei Yamaguchi, Masatoshi Beppu, Hirota Fujiki, Masami Suganuma

BIOLOGICAL & PHARMACEUTICAL BULLETIN 33(5) 796-803 2010年5月査読有り
Plasma KL-6 predicts the development and outcome of bronchopulmonary dysplasia

Tohru Ogihara, Kazuya Hirano, Takao Morinobu, Han-Suk Kim, Satoru Ogawa, Mayo Hirol, Shinya Oue, Ryoichi Ban, Seigo Hira, Masashi Hasegawa …

PEDIATRIC RESEARCH 60(5) 613-618 2006年11月査読有り

MISC

Nucleolin as cell surface receptor for tumor necrosis factor-alpha inducing protein: a carcinogenic factor of Helicobacter pylori

Tatsuro Watanabe, Hideaki Tsuge, Takahito Imagawa, Daisuke Kise, Kazuya Hirano, Masatoshi Beppu, Atsushi Takahashi, Kensei Yamaguchi, Hirota Fujiki, Masami Suganuma

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 136(6) 911-921 2010年6月
Nucleolin as cell surface receptor for tumor necrosis factor-alpha inducing protein: a carcinogenic factor of Helicobacter pylori

Tatsuro Watanabe, Hideaki Tsuge, Takahito Imagawa, Daisuke Kise, Kazuya Hirano, Masatoshi Beppu, Atsushi Takahashi, Kensei Yamaguchi, Hirota Fujiki, Masami Suganuma

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 136(6) 911-921 2010年6月
Clearance of oxidatively damaged cells by macrophages: recognition of glycoprotein clusters by macrophage-surface nucleolin as early apoptotic cells.

Miki Y, Itoh T, Hirano K, Eda S, Hayashi A, Yamanaka M, Beppu M

Biol Pharm Bull. 32(4) 564-572 2009年
Clearance of oxidatively damaged cells by macrophages: recognition of glycoprotein clusters by macrophage-surface nucleolin as early apoptotic cells.

Miki Y, Itoh T, Hirano K, Eda S, Hayashi A, Yamanaka M, Beppu M

Biol Pharm Bull. 32(4) 564-572 2009年
Clearance of oxidized erythrocytes by macrophages: Involvement of caspases in the generation of clearance signal at band 3 glycoprotein

Yuichi Miki, Tomoki Tazawa, Kazuya Hirano, Hideki Matsushima, Shoko Kumamoto, Naotaka Hamasaki, Tomohiro Yamaguchi, Masatoshi Beppu

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 363(1) 57-62 2007年11月
Clearance of oxidized erythrocytes by macrophages: Involvement of caspases in the generation of clearance signal at band 3 glycoprotein

Yuichi Miki, Tomoki Tazawa, Kazuya Hirano, Hideki Matsushima, Shoko Kumamoto, Naotaka Hamasaki, Tomohiro Yamaguchi, Masatoshi Beppu

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 363(1) 57-62 2007年11月
Retardation of removal of radiation-induced apoptotic cells in developing neural tubes in macrophage galactose-type C-type lectin-1-deficient mouse embryos

H Yuita, M Tsuiji, Y Tajika, Y Matsumoto, K Hirano, N Suzuki, T Irimura

GLYCOBIOLOGY 15(12) 1368-1375 2005年12月
A multifunctional shuttling protein nucleolin is a macrophage receptor for apoptotic cells

K Hirano, Y Miki, Y Hirai, R Sato, T Itoh, A Hayashi, M Yamanaka, S Eda, M Beppu

JOURNAL OF BIOLOGICAL CHEMISTRY 280(47) 39284-39293 2005年11月
A multifunctional shuttling protein nucleolin is a macrophage receptor for apoptotic cells

K Hirano, Y Miki, Y Hirai, R Sato, T Itoh, A Hayashi, M Yamanaka, S Eda, M Beppu

JOURNAL OF BIOLOGICAL CHEMISTRY 280(47) 39284-39293 2005年11月
Decreased c-Myc expression and its involvement in X-ray-induced apoptotic cell death of human T-cell leukaemia cell line MOLT-4

A Enomoto, N Suzuki, Y Kang, K Hirano, Y Matsumoto, J Zhu, A Morita, Y Hosoi, K Sakai, H Koyama

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 79(8) 589-600 2003年8月
Wortmannin-enhanced X-ray-induced apoptosis of human T-cell leukemia MOLT-4 cells possibly through the JNK/SAPK pathway.

Masanori Tomita, Norio Suzuki, Yoshihisa Matsumoto, Atsushi Enomoto, HL Yin, Yoshio Hosoi, Kazuya Hirano, Kazuo Sakai

Radiat Res. 160(4) 467-477 2003年
Effect of Estrogenic Compounds on Superoside Production by Activated Macrophages Assessed by Sensitive Microplate assays

Wataru Yoshida, Minori Ogawa, Yuko Furuoya, Yu Igarashi, Rumi Sato, Akiko Hayashi, Kazuya Hirano, Masatoshi Beppu

J. Health Sci. 48, 455-459 (2002) J. Health Sci. 48(5) 455-459 2002年
Cleavage and phosphorylation of XRCC4 protein induced by X-irradiation

Y Matsumoto, N Suzuki, N Namba, N Umeda, XJ Ma, A Morita, M Tomita, A Enomoto, S Serizawa, K Hirano …

FEBS LETTERS 478(1-2) 67-71 2000年7月
Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human T-cell leukemia cell line MOLT-4

A Enomoto, N Suzuki, K Hirano, Y Matsumoto, A Morita, K Sakai, H Koyama

CANCER LETTERS 155(2) 137-144 2000年7月
Increased expression after X-irradiation of MUC1 in cultured human colon carcinoma HT-29 cells

Y Kang, K Hirano, N Suzuki, A Enomoto, A Morita, T Irimura, K Sakai

JAPANESE JOURNAL OF CANCER RESEARCH 91(3) 324-330 2000年3月
p41 as a Possible Marker for Cell Death Is Generated by Caspase Cleavage of p42/SETb in Irradiated MOLT-4 Cells

Akinori Morita, Norio Suzuki, Yoshihisa Matsumoto, Kazuya Hirano, Atsushi Enomoto, Jin Zhu, Kazuo Sakai

Biochem. and Biophys. Res. Com. 278(3) 627-632 2000年
Sensitization by Wortmannin of Heat or Radiation Induced Cell Death in Cultured Chinese Hamster V79 cells.

Masanori Tomita, Norio Suzuki, Yoshihisa Matsumoto, Kazuya Hirano, Noriko Umeda, Kazuo Sakai

J. Radiat. Res. 41(2) 93-102 2000年
Characterization of the expression of MUCI mucin in human colon carcinoma HT29 cells after exposure to X-ray

Journal of Radiation Research 38(4) 1997年
Identification and characterization of a protein found after X-irradiation in human T cell leukemia

Journal of Radiation Research 1996年
CDNA CLONING OF MOUSE VLA-3 ALPHA-SUBUNIT

K TAKEUCHI, K HIRANO, T TSUJI, T OSAWA, T IRIMURA

JOURNAL OF CELLULAR BIOCHEMISTRY 57(2) 371-377 1995年2月

もっとみる

担当経験のある科目(授業)

所属学協会

共同研究・競争的資金等の研究課題

アポトーシス細胞除去機構の解析

科学研究費補助金 2006年 - 2007年
A macrophage receptor for the carbohydrate-mediated recognition of apoptotic cells

科学研究費補助金 2001年 - 2003年
Characterization of the expression of MUC1 mucin after X-ray irradiation