2019年1月1日
Tetradehydrohalicyclamine B, a new proteasome inhibitor from the marine sponge Acanthostrongylophora ingens
Bioorganic and Medicinal Chemistry Letters
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- 巻
- 29
- 号
- 1
- 開始ページ
- 8
- 終了ページ
- 10
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bmcl.2018.11.028
- 出版者・発行元
- Elsevier {BV}
© 2018 Elsevier Ltd A new halicyclamine derivative, tetradehydrohalicyclamine B (1), was isolated from the marine sponge Acanthostrongylophora ingens, along with halicyclamine B (2) as proteasome inhibitors. Compound 1 is the second example found to have a pyridinium ring in the halicyclamine family. Although the relative configuration of 2 was previously determined by X-ray crystallographic analysis, here we determined the absolute configuration of 2 by ECD experiment. Compounds 1 and 2 inhibited the constitutive proteasome as well as the immunoproteasome. The inhibitory activities of 2 were 4- to 10-fold more potent than those of 1.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.bmcl.2018.11.028
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/30455150
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85056666116&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85056666116&origin=inward
- URL
- http://orcid.org/0000-0002-7993-381X
- ID情報
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- DOI : 10.1016/j.bmcl.2018.11.028
- ISSN : 0960-894X
- eISSN : 1464-3405
- ORCIDのPut Code : 50604861
- PubMed ID : 30455150
- SCOPUS ID : 85056666116