論文

査読有り
2018年

Expression of prolactin receptor mrna in lactotrophs and somatotrophs of the chicken anterior pituitary gland

Journal of Poultry Science
  • Hiromi Kaneda
  • ,
  • Nobuhiro Nakao
  • ,
  • Nobumichi Tsushima
  • ,
  • Minoru Tanaka

55
2
開始ページ
150
終了ページ
154
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2141/jpsa.0170082
出版者・発行元
Japan Poultry Science Association

Prolactin (PRL) is a hormone mainly secreted by the anterior pituitary gland. In birds, PRL exerts a variety of physiological functions in target tissues expressing the PRL receptor (PRLR). In chicken, the PRLR mRNA is abundant in the anterior pituitary gland, but its regional and cellular localization are unknown. In the present study, we investigated the expression of the PRLR mRNA in cephalic and caudal lobes of the chicken anterior pituitary gland. Real-time polymerase chain reaction (PCR) revealed high levels of PRLR mRNA in both cephalic and caudal lobes. In situ hybridization revealed that the PRLR mRNA was distributed in a wide area of both lobes, and co-localized with the PRL and growth hormone (GH) mRNAs in the cephalic and caudal lobes, respectively. These results suggest that PRL exerts autocrine/paracrine effects through PRLR on PRL-producing lactotrophs and GH-producing somatotrophs in the chicken anterior pituitary gland.


リンク情報
DOI
https://doi.org/10.2141/jpsa.0170082
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000431388100009&DestApp=WOS_CPL

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