2015年9月
Mechanical properties of a bioabsorbable nerve guide tube for long nerve defects
CHIRURGIE DE LA MAIN
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- 巻
- 34
- 号
- 4
- 開始ページ
- 186
- 終了ページ
- 192
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.main.2015.05.004
- 出版者・発行元
- ELSEVIER
The mechanical properties of nerve guide tubes must be taken into consideration when they are being developed. We previously reported the feasibility of using 50:50 tubes in a canine 40 mm peroneal nerve defect model, where 50:50 represents the proportion of poly(L-lactic) acid (PLLA) and polyglycolic acid (PGA). The aim of the current study was to show that 50:50 tubes have suitable mechanical properties for repairing long nerve defects. Four types of nerve guide tubes made with PLLA to PGA fiber ratios of 100:0 (i.e. 100% PLLA) (100:0 tube), 50:50 (50:50 tube), 10:90 (10:90 tube), and 0:100 (0:100 tube) were designed and created using a tubular braiding machine. Their mechanical properties were examined in vitro (up to 16 weeks). In compression testing, 50:50 tubes had the highest normalized force value, followed in order by the 100:0, 10:90, and 0:100 tubes up to 8 weeks after immersion. From the point of view of biomechanics and bioresorbability, out of the 4 tube types tested, 50:50 tubes appeared to have the optimal mechanical properties for longer nerve defects. (C) 2015 Elsevier Masson SAS. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.main.2015.05.004
- ISSN : 1297-3203
- eISSN : 1769-6666
- Web of Science ID : WOS:000362931800003