2005年6月
Palladium(0)-catalyzed tandem cyclization of allenenes: Direct construction of tricyclic heterocycles through aromatic C-H activation
CHEMISTRY-A EUROPEAN JOURNAL
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- 巻
- 11
- 号
- 12
- 開始ページ
- 3728
- 終了ページ
- 3741
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/chem.200500050
- 出版者・発行元
- WILEY-V C H VERLAG GMBH
Palladium (0) -catalyzed tandem cyclization of allenenes is described. Treatment of allenenes with an aryl halide, potassium carbonate. and catalytic [Pd(PPh3)(4)] in dioxane afforded tri- or tetracyclic heterocycles in moderate to good yields through insertion of arylpalladium(ii) halide into the allenic moiety, intramolecular carbopalladation, and aromatic C-H bond activation. The substituent on the olefin terminus has proven to be essential for the success of the tandem cyclization, The reaction with heterocyclic aryl halides such as iodopyrazine or 4-bromo-1-triethylindole afforded tri- or tetracyclic heteroaromatic products in good yields.
- リンク情報
- ID情報
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- DOI : 10.1002/chem.200500050
- ISSN : 0947-6539
- PubMed ID : 15815992
- Web of Science ID : WOS:000229729300025