論文

査読有り
2005年6月

Palladium(0)-catalyzed tandem cyclization of allenenes: Direct construction of tricyclic heterocycles through aromatic C-H activation

CHEMISTRY-A EUROPEAN JOURNAL
  • H Ohno
  • ,
  • K Miyamura
  • ,
  • T Mizutani
  • ,
  • Y Kadoh
  • ,
  • Y Takeoka
  • ,
  • H Hamaguchi
  • ,
  • T Tanaka

11
12
開始ページ
3728
終了ページ
3741
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/chem.200500050
出版者・発行元
WILEY-V C H VERLAG GMBH

Palladium (0) -catalyzed tandem cyclization of allenenes is described. Treatment of allenenes with an aryl halide, potassium carbonate. and catalytic [Pd(PPh3)(4)] in dioxane afforded tri- or tetracyclic heterocycles in moderate to good yields through insertion of arylpalladium(ii) halide into the allenic moiety, intramolecular carbopalladation, and aromatic C-H bond activation. The substituent on the olefin terminus has proven to be essential for the success of the tandem cyclization, The reaction with heterocyclic aryl halides such as iodopyrazine or 4-bromo-1-triethylindole afforded tri- or tetracyclic heteroaromatic products in good yields.

リンク情報
DOI
https://doi.org/10.1002/chem.200500050
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/15815992
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000229729300025&DestApp=WOS_CPL
ID情報
  • DOI : 10.1002/chem.200500050
  • ISSN : 0947-6539
  • PubMed ID : 15815992
  • Web of Science ID : WOS:000229729300025

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