2010年5月
Construction of Linked Nitrogen Heterocycles by Palladium(0)-Catalyzed Intramolecular Domino Cyclization of 2-Alkynylaziridines Bearing a 2-Aminoethyl Group via Ring Expansion with Isocyanate
JOURNAL OF ORGANIC CHEMISTRY
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- 巻
- 75
- 号
- 10
- 開始ページ
- 3396
- 終了ページ
- 3400
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/jo100462w
- 出版者・発行元
- AMER CHEMICAL SOC
A novel palladium(0)-catalyzed domino cyclization of 2-alkynylaziridines with isocyanates through ring expansion is described. Treatment of N-protected 2-(4-aminobut-1-ynyl)aziridine derivatives With a catalytic amount of Pd(PPh(3))(4) and aryl isocyanates in THF at room temperature affords 4-(4,5-dihydropyrrol-2-yl)imidazolidin-2-one derivatives in good yields. Interestingly, bis-adducts were selectively obtained by use of excess isocyanate (5 equiv) at lower reaction temperature.
- リンク情報
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- DOI
- https://doi.org/10.1021/jo100462w
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201002261578419056
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/20405897
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000277531200027&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1021/jo100462w
- ISSN : 0022-3263
- J-Global ID : 201002261578419056
- PubMed ID : 20405897
- Web of Science ID : WOS:000277531200027