KABAYAMA Kazuya

J-GLOBAL         Last updated: Dec 7, 2018 at 13:04
 
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Name
KABAYAMA Kazuya
URL
http://www.tsc.u-tokai.ac.jp/pubhome/glyco/
Affiliation
Osaka University
Section
Glycotechnology Research Center
Job title
Associate Professor
Degree
(BLANK)

Research Areas

 
 

Academic & Professional Experience

 
2014
 - 
Today
Associate Professor, Graduate School of Science, Osaka University
 

Education

 
 
 - 
1999
Graduate School, Division of Science and Engineering, Keio University
 
 
 - 
1997
Faculty of Science and Engineering, Keio University
 

Published Papers

 
Hisao Kojima, Yusuke Suzuki, Masahiro Ito, Kazuya Kabayama
Lipids   50(9) 913-917   May 2015   [Refereed]
© 2015 The Author(s) In recent years, obesity has been considered a pathological stage of early lifestyle-related diseases, and adipose tissue and adipocyte research has been active. Glycosphingolipids are involved in the pathogenesis of type 2 di...
Suzuki Yusuke, Okano Aya, Kabayama Kazuya, Nishina Atsuyoshi, Tanigawa Minoru, Nishimura Katsushi, Kushi Yasunori
ANALYTICAL SCIENCES   32(5) 487-490   May 2016   [Refereed]
[Electrostatic interaction between ganglioside and membrane proteins].
Kabayama K
Seikagaku. The Journal of Japanese Biochemical Society   88(6) 782-785   Dec 2016   [Refereed]
Horayama M, Shinha K, Kabayama K, Fujii T, Kimura H
PloS one   11(12) e0168158   Dec 2016   [Refereed]
A study toward understanding cellular dynamics of glycosphingolipid based on chemical engineering approach
Arai Kenta, Kimura Hiroshi, Kabayama Kazuya, Kanie Osamu
GLYCOBIOLOGY   24(11) 1113   Nov 2014   [Refereed]
Son SH, Daikoku S, Ohtake A, Suzuki K, Kabayama K, Ito Y, Kanie O
Chemical communications (Cambridge, England)   50(23) 3010-3013   Mar 2014   [Refereed]
Hiroshi Kuwahata, Takeshi Yamaguchi, Hisao Kojima, Kazuya Kabayama
e-Journal of Surface Science and Nanotechnology   12 400-403   Aug 2014
© 2014 The Surface Science Society of Japan. To clarify the mechanism underlying the inactivation of Escherichia coli (E. coli) cells subjected to atmospheric-pressure argon (Ar) plasma jet irradiation, we focused on phospholipids, the main compon...
Masayuki Horayama,Tomoki Ohkubo,Kenta Arai,Kazuya Kabayama,Teruo Fujii,Hiroshi Kimura
2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014, Nagoya, Japan, November 10-12, 2014   1-2   2014   [Refereed]
Zamri N, Masuda N, Oura F, Kabayama K, Yajima Y, Nakada H, Yamamoto K, Fujita-Yamaguchi Y
Bioscience trends   7(5) 221-229   Oct 2013   [Refereed]
Kijimoto-Ochiai S, Doi N, Fujii M, Go S, Kabayama K, Moriya S, Miyagi T, Koda T
Microbiology and immunology   57(8) 569-582   Aug 2013   [Refereed]
Hisashi Kamimiya, Yusuke Suzuki, Anila Mathew, Anila Mathew, Kazuya Kabayama, Hisao Kojima, Yasunori Kushi
Analytical Methods   5(23) 6617-6621   Dec 2013   [Refereed]
Extraction of thin-layer chromatography (TLC) spot with organic solvents is one of the convenient methods for glycolipid isolation from crude samples, but other background contaminants are also co-extracted during this process. Calcium sulfate (gy...
Kojima H, Tohsato Y, Kabayama K, Itonori S, Ito M
Glycoconjugate journal   30(3) 257-268   Apr 2013   [Refereed]
Haruka Shinohara, Rio Kita, Naoki Shinyashiki, Shin Yagihara, Kazuya Kabayama, Toshiyuki Inazu
AIP Conference Proceedings   1518 710-713   Mar 2013   [Refereed]
The Ludwig-Soret effect for aqueous solutions of α-cyclodextrin (CD), β-CD, γ-CD, and glucose was studied by thermal diffusion forced Rayleigh scattering (TDFRS) in the temperature range of 15-55°C. The Soret coefficient and the thermal diffusion ...
Sekimoto J, Kabayama K, Gohara K, Inokuchi J
FEBS letters   586(2) 191-195   Jan 2012   [Refereed]
Suzuki Y, Kabayama K
Journal of lipid research   53(3) 599-608   Mar 2012   [Refereed]
Yoshikawa M, Go S, Takasaki K, Kakazu Y, Ohashi M, Nagafuku M, Kabayama K, Sekimoto J, Suzuki S, Takaiwa K, Kimitsuki T, Matsumoto N, Komune S, Kamei D, Saito M, Fujiwara M, Iwasaki K, Inokuchi J
Proceedings of the National Academy of Sciences of the United States of America   106(23) 9483-9488   Jun 2009   [Refereed]
Kabayama K
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan   132 417-423   2012   [Refereed]
Noguchi M, Suzuki T, Kabayama K, Takahashi H, Chiba H, Shiratori M, Abe S, Watanabe A, Satoh M, Hasegawa T, Tagami S, Ishii A, Saitoh M, Kaneko M, Iseki K, Igarashi Y, Inokuchi J
Cancer science   98(10) 1625-1632   Oct 2007   [Refereed]
Jin Ichi Inokuchi, Kazuya Kabayama
Trends in Glycoscience and Glycotechnology   20(116) 353-371   Dec 2008   [Refereed]
Gangliosides have been shown to modulate various growth factor receptors such as epidermal growth factor receptor (EGFR), insulin receptor (IR), platelet derived growth factor receptor (PDGFR), neural growth factor receptor (NGFR) and fibroblast g...
Satoshi Uemura, Satoshi Uemura, Satoshi Uemura, Fei Feng, Maya Kume, Kuriko Yamada, Kazuya Kabayama, Kazuya Kabayama, Kazuya Kabayama, Shin Ichiro Nishimura, Shin Ichiro Nishimura, Yasuyuki Igarashi, Jin Ichi Inokuchi, Jin Ichi Inokuchi, Jin Ichi Inokuchi
Glycobiology   17(6) 568-577   Jun 2007   [Refereed]
Ganglioside GM3, one of the sialic acid containing glycosphingolipids, is known to form clusters in lipid microdomains, which serve as platforms for effective signal transduction. In an attempt to clarify the GM3 cluster effect, we enzymatically s...
Kabayama K, Sato T, Saito K, Loberto N, Prinetti A, Sonnino S, Kinjo M, Igarashi Y, Inokuchi J
Proceedings of the National Academy of Sciences of the United States of America   104(34) 13678-13683   Aug 2007   [Refereed]
[Regulation of insulin receptor function in microdomains].
Inokuchi J, Kabayama K, Nagafuku M, Sato T
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   53 1552-1557   Sep 2008   [Refereed]
Noguchi M, Kabayama K, Uemura S, Kang BW, Saito M, Igarashi Y, Inokuchi J
Glycobiology   16 641-650   Jul 2006   [Refereed]
Tani-ichi S, Maruyama K, Kondo N, Nagafuku M, Kabayama K, Inokuchi J, Shimada Y, Ohno-Iwashita Y, Yagita H, Kawano S, Kosugi A
International immunology   17 749-758   Jun 2005   [Refereed]
Kabayama K, Sato T, Kitamura F, Uemura S, Kang BW, Igarashi Y, Inokuchi J
Glycobiology   15 21-29   Jan 2005   [Refereed]
Matsumoto K, Sato T, Oka S, Orba Y, Sawa H, Kabayama K, Inokuchi J, Ariga H
Genes to cells : devoted to molecular & cellular mechanisms   9 737-748   Aug 2004   [Refereed]
Ogawa S, Sakata Y, Ito N, Watanabe M, Kabayama K, Itoh M, Korenaga T
Bioorganic & medicinal chemistry   12 995-1002   Mar 2004   [Refereed]
Inokuchi J, Kabayama K, Uemura S, Igarashi Y
Glycoconjugate journal   20 169-178   2004   [Refereed]
Nagafuku M, Kabayama K, Oka D, Kato A, Tani-ichi S, Shimada Y, Ohno-Iwashita Y, Yamasaki S, Saito T, Iwabuchi K, Hamaoka T, Inokuchi J, Kosugi A
The Journal of biological chemistry   278 51920-51927   Dec 2003   [Refereed]
Uemura S, Kabayama K, Noguchi M, Igarashi Y, Inokuchi J
Glycobiology   13 207-216   Mar 2003   [Refereed]
[Biological significance of lactosylceramide branching and domain formation: glycosphingolipids govern gene expression].
Inokuchi J, Kabayama K, Uemura S, Igarashi Y
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   47 371-378   Mar 2002   [Refereed]
Tagami S, Inokuchi Ji J, Kabayama K, Yoshimura H, Kitamura F, Uemura S, Ogawa C, Ishii A, Saito M, Ohtsuka Y, Sakaue S, Igarashi Y
The Journal of biological chemistry   277 3085-3092   Feb 2002   [Refereed]
Kazuya Kabayama, Nozomi Ito, Koichi Honke, Yasuyuki Igarashi, Jin Ichi Inokuchi, Jin Ichi Inokuchi
Journal of Biological Chemistry   276, 26777-26783 26777-26783   Jul 2001
To investigate the cellular functions of sulfated glycosphingolipids, we introduced the cerebroside sulfotransferase (CST) gene into J5 cells, a subclone of 3LL Lewis lung carcinoma cells. The J5 cells lack acidic glycosphingolipids but accumulate...
J. I. Inokuchi, S. Uemura, K. Kabayama, Y. Igarashi
Glycoconjugate Journal   17, 239-245 239-245   Dec 2000
In view of the increasing evidence that gangliosides in membrane microdomains or rafts are closely associated with various signal transducing molecules including Src family kinases, we compared rafts in two subclones of 3LL mouse lung carcinoma ce...
Masayuki Jimbo, Kiwamu Yamagishi, Toshiaki Yamaki, Katsuyuki Nunomura, Kazuya Kabayama, Yasuyuki Igarashi, Jin Ichi Inokuchi
Journal of Biochemistry   127, 485-491 485-491   Apr 2000
Analogs of the potent inhibitor of glucosylceramide (GlcCer) synthase, D-threo-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (P4), based on substitutions in the palmitoyl group were made by means of a stereo-selective synthetic method in orde...
Seiichiro Ogawa, Yuko Kobayashi, Kazuya Kabayama, Masayuki Jimbo, Jin ichi Inokuchi, Jin ichi Inokuchi
Bioorganic and Medicinal Chemistry   6 1955-1962   Oct 1998
Several N-alkanoyl 4a-d and N-alkyl derivatives 5a-g of the potent β-glucocerebrosidase inhibitor N-octyl β-valienamine (3) were synthesized in order to elucidate a role of hydrophobic portion in the inhibitory action. Although the former lacked i...

Misc

 
Wataru Nihei, Masakazu Nagafuku, Hirotaka Hayamizu, Yuta Odagiri, Yumi Tamura, Yui Kikuchi, Lucas Veillon, Lucas Veillon, Hirotaka Kanoh, Kei Ichiro Inamori, Kenta Arai, Kazuya Kabayama, Koichi Fukase, Jin Ichi Inokuchi
Journal of lipid research   59 2181-2187   Nov 2018
Copyright © 2018 Nihei et al. Intestinal cholesterol absorption is a key regulator of systemic cholesterol homeostasis. Excessive dietary cholesterol and its intestinal uptake lead to hypercholesterolemia, a major risk factor for cardiovascular di...
Tsung Che Chang, Yoshiyuki Manabe, Yoshiyuki Manabe, Yukari Fujimoto, Shino Ohshima, Yoshie Kametani, Kazuya Kabayama, Kazuya Kabayama, Yuka Nimura, Chun Cheng Lin, Koichi Fukase, Koichi Fukase
Angewandte Chemie - International Edition   57 8219-8224   Jul 2018
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Sialyl-Tn (STn) is a tumor-associated carbohydrate antigen (TACA) rarely observed on healthy tissues. We synthesized two fully synthetic N-acetyl and N-propionyl STn trimer (triSTn) vaccines poss...
Junichiro Ono, Junichiro Ono, Satoko Fushimi, Shingo Suzuki, Kiyoshi Ameno, Hiroshi Kinoshita, Gotaro Shirakami, Kazuya Kabayama
FEBS Open Bio   8 1127-1134   Jul 2018
© 2018 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. The volatile anesthetic isoflurane (ISO) has previously been shown to increase the fluidity of artificial lipid membranes, but very few studies have used biological cell memb...
Hong Zhang, Takuto Aoki, Kanae Hatano, Kazuya Kabayama, Masaru Nakagawa, Koichi Fukase, Yosuke Okamura, Yosuke Okamura
Journal of Materials Chemistry B   6 6622-6628   Jan 2018
© 2018 The Royal Society of Chemistry. In the field of cell imaging, it is still a practical challenge to obtain the high quality live imaging of suspension cells, mainly due to undesirable cell movement in the imaging field during observation. Th...
Jin ichi Inokuchi, Kei ichiro Inamori, Kazuya Kabayama, Masakazu Nagafuku, Satoshi Uemura, Shinji Go, Akemi Suzuki, Isao Ohno, Hirotaka Kanoh, Fumi Shishido
Progress in Molecular Biology and Translational Science   156 151-195   Jan 2018
© 2017 Since the successful molecular cloning in 1998 of GM3 synthase (GM3S, ST3GAL5), the enzyme responsible for initiating biosynthesis of all complex gangliosides, the efforts of our research group have been focused on clarifying the physiologi...
Kazuya Kabayama
Trends in Glycoscience and Glycotechnology   30    Jan 2018
© 2018 FCCA (Forum: Carbohydrates Coming of Age) Glycosphingolipids are not uniformly present in cell membranes and form microdomains called glycolipid microdomains together with sphingomyelin and cholesterol. Many signaling molecules accumulate t...
Yohei Arai, Kouhei Yokoyama, Yuki Kawahara, Qi Feng, Ippei Ohta, Atsushi Shimoyama, Shinsuke Inuki, Shinsuke Inuki, Koichi Fukase, Kazuya Kabayama, Yukari Fujimoto
Organic and Biomolecular Chemistry   16 3824-3830   Jan 2018
© 2018 The Royal Society of Chemistry. As a mammalian toll-like receptor family member protein, TLR2 recognizes lipoproteins from bacteria and modulates the immune response by inducing the expression of various cytokines. We have developed fluores...
Yusuke Suzuki, Aya Okano, Kazuya Kabayama, Atsuyoshi Nishina, Minoru Tanigawa, Katsushi Nishimura, Yasunori Kushi
Analytical Sciences   32 487-490   Jan 2016
© The Japan Society for Analytical Chemistry.Fluorescence derivatization of the oligosaccharides released from glycoconjugates is widely used for precise structural characterization. To ensure labeling of the oligosaccharides, a large excess of fl...
Horayama Masayuki, Ohkubo Tomoki, Arai Kenta, Kabayama Kazuya, Fujii Teruo, Kimura Hiroshi
Mechanical Engineering Congress, Japan   2015 "J0220203-1"-"J0220203-5"   Sep 2015
In this study, we have developed a microfluidic device to control chemical stimulation to a cell population at a single cell scale for cell-based assay. The device consists of a cell culture chamber and microfluidic probe (MFP) channels which are ...
Masayuki Horayama, Tomoki Ohkubo, Kenta Arai, Kazuya Kabayama, Teruo Fujii, Hiroshi Kimura
2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014      Jan 2015
© 2014 IEEE.In this study, we have developed a microfluidic device to control chemical stimulation to a cell population at a single cell scale for cell-based assay. The device consists of a cell culture chamber and microfluidic probe (MFP) channel...
Yong Hyeon Lee, Dong Hyun Seo, Ji Hyung Park, Kazuya Kabayama, Joerg Opitz, Kwang Ho Lee, Han Sung Kim, Tack Joong Kim
Evidence-based Complementary and Alternative Medicine   2015    Jan 2015
© 2015 Yong-Hyeon Lee et al.Muscle atrophy, a reduction of muscle mass, strength, and volume, results from reduced muscle use and plays a key role in various muscular diseases. In the microgravity environment of space especially, muscle atrophy is...
Kazuya Kabayama, Hisao Kojima, Yusuke Suzuki
Glycoscience: Biology and Medicine   1181-1184   Jan 2015
© Springer Japan 2015.To elucidate function of glycolipid raft, analyses by live cell imaging and mass spectrometry were greatly paid attention. Especially, the former has been developed more and more as for methodology. This chapter shows the ass...
KUWAHATA Hiroshi, YAMAGUCHI Takeshi, KOJIMA Hisao, KABAYAMA Kazuya
J. Surf. Sci. Soc. Jpn.   36(5) 257-262   2015
The aim of this study was to determine the effect of plasma irradiation, which is used in plasma medicine on biological tissues (cells). We used phospholipids, the main components of the cell membrane, namely, phosphatidylcholine (PC), phosphatidy...
Horayama Masayuki, Okubo Tomoki, Arai Kenta, Kabayama Kazuya, Fujii Teruo, Kimura Hiroshi
マイクロ・ナノ工学シンポジウム   2014(6) "20pm3-PM015-1"-"20pm3-PM015-2"   Oct 2014
In this study, we have developed a microfluidic device to control chemical stimulation to a cell population at a single cell scale for cell-based assay. The device consists of a cell culture chamber and microfluidic probe (MFP) channels which are ...
Horayama Masayuki, Ohkubo Tomoki, Arai Kenta, Kabayama Kazuya, Fuji Teruo, Kimura Hiroshi
Conference on Information, Intelligence and Precision Equipment : IIP   2014 "H-2-4-1"-"H-2-4-2"   Mar 2014
In this study, we have developed a microfluidic device integrated with a microfluidic probe to clarify a differentiation mechanism of pluripotent stem cells. It is difficult to evaluate efficacy of chemical reagents for the differentiation using a...
Masayuki Horayama, Tomoki Ohkubo, Kenta Arai, Kazuya Kabayama, Teruo Fujii, Hiroshi Kimura
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014   558-560   Jan 2014
© 14CBMS.In this study, we have developed a microfluidic device to control chemical stimulation to a cell population at a single cell scale for cell-based assay. The device consists of a cell culture chamber and microfluidic probe (MFP) channels w...
Horayama Masayuki, Ohkubo Tomoki, Arai Kenta, Kabayama Kazuya, Fujii Teruo, Kimura Hiroshi
Proceedings of JSPE Semestrial Meeting   2014(0) 135-136   2014
本研究では,細胞アッセイに向けて,細胞集団に対して一細胞スケールでの液性刺激制御が可能なマイクロ流体デバイスの開発を行っている.本デバイスは,マイクロ流体プローブと呼ばれる微小領域の液性刺激制御が可能なデバイスの機能を細胞培養流路部に集積化することで,一細胞スケールでの液性因子曝露を可能としている.これまでに,本デバイスを用いた流体制御手法を確立し,細胞集団に対する部位局所的な液性刺激を実現した.
樺山一哉, 小島寿夫, 鈴木佑典
Chem Times   2013(3) 15-22   Jul 2013
KABAYAMA KAZUYA
薬学雑誌   132(4) 417-423 (J-STAGE)   2012
樺山一哉
脂質ドメインのダイナミクスと細胞機能 第53回日本脂質生化学会シンポジウム 理研シンポジウム 平成23年   9-11   2011
井ノ口仁一, 樺山一哉, 永福正和, 佐藤貴繁
蛋白質 核酸 酵素   53(12) 1552-1557   Sep 2008
井ノ口 仁一, 樺山 一哉, 永福 正和
Protein, nucleic acid and enzyme   53(12) 1552-1557   Sep 2008
樺山一哉, 井ノ口仁一
Lung Perspect   16(2) 226-232   Apr 2008
Jin Ichi Inokuchi, Jin Ichi Inokuchi, Kazuya Kabayama, Takashige Sato, Yasuyuki Igarashi
Sphingolipid Biology   273-284   Dec 2006
Membrane microdomains (lipid rafts), which are critical for proper compartmentalization of insulin signaling, also play a role in the pathogenesis of insulin resistance, and yet this role has not been investigated. Detergent-resistant membrane mic...
Glycoconj. J.   20, 169-178    2004
INOKUCHI JIN'ICHI, KABAYAMA KAZUYA, UEMURA SATOSHI, IGARASHI YASUYUKI
蛋白質 核酸 酵素   47(4) 371-378   Mar 2002
Masserini Massimo, Ravasi Daniela, Sonnino Sandro
TIGG   13(71) 239-250   2001
Recent years have been characterized by a huge interest in the structure and function of mammalian cell membrane lipid domains. The interest in this subject grew further, when their participation in important membrane-associated events such as sig...

Research Grants & Projects

 
Modulator of Glycosphingolipid Biosynthesis ; Application of Cell Biology