MISC

2014年7月

F-18-FDG uptake predicts diagnostic yield of transbronchial biopsy in peripheral lung cancer

LUNG CANCER
  • Yukihiro Umeda
  • ,
  • Yoshiki Demura
  • ,
  • Masaki Anzai
  • ,
  • Hiroki Matsuoka
  • ,
  • Tomoyuki Araya
  • ,
  • Masaru Nishitsuji
  • ,
  • Koichi Nishi
  • ,
  • Tatsuro Tsuchida
  • ,
  • Yasuyuki Sumida
  • ,
  • Miwa Morikawa
  • ,
  • Shingo Ameshima
  • ,
  • Takeshi Ishizaki
  • ,
  • Kazuo Kasahara
  • ,
  • Tamotsu Ishizuka

85
1
開始ページ
47
終了ページ
52
記述言語
英語
掲載種別
DOI
10.1016/j.lungcan.2014.03.025
出版者・発行元
ELSEVIER IRELAND LTD

Objectives: Recent advances in endobronchial ultrasonography with a guide sheath (EBUS-GS) have enabled better visualization of distal airways, while virtual bronchoscopic navigation (VBN) has been shown useful as a guide to navigate the bronchoscope. However, indications for utilizing VBN and EBUS-GS are not always clear. To clarify indications for a bronchoscopic examination using VBN and EBUS-GS, we evaluated factors that predict the diagnostic yield of a transbronchial biopsy (TBB) procedure for peripheral lung cancer (PLC) lesions.
Methods: We retrospectively reviewed the charts of 194 patients with 201 PLC lesions (<= 3 cm mean diameter), and analyzed the association of diagnostic yield of TBB with [F-18]-fluoro-2-deoxy-D-glucose (F-18-FDG) positron emission tomography and chest computed tomography (CT) findings.
Results: The diagnostic yield of TBB using VBN and EBUS-GS was 66.7%. High maximum standardized uptake value (SUVmax), positive bronchus sign, and ground-glass opacity component shown on CT were all significant predictors of diagnostic yield, while multivariate analysis showed only high F-18-FDG uptake (SUVmax >= 2.8) and positive bronchus sign as significant predictors. Diagnostic yield was higher for PLC lesions with high F-18-FDG uptake (SUVmax >= 2.8) and positive bronchus sign (84.6%) than for those with SUVmax <2.8 and negative bronchus sign (33.3%). High F-18-FDG uptake was also correlated with tumor invasiveness.
Conclusions: High F-18-FDG uptake predicted the diagnostic yield of TBB using VBN and EBUS-GS for PLC lesions. F-18-FDG uptake and bronchus sign may indicate for the accurate application of bronchoscopy with those modalities for diagnosing PLC. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

Web of Science ® 被引用回数 : 6

リンク情報
DOI
https://doi.org/10.1016/j.lungcan.2014.03.025
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000338617100008&DestApp=WOS_CPL