MISC

国際誌
2013年6月

(18)F-FDG PET/CT for Diagnosis of Osteosclerotic and Osteolytic Vertebral Metastatic Lesions: Comparison with Bone Scintigraphy.

Asian spine journal
  • Kenzo Uchida
  • ,
  • Hideaki Nakajima
  • ,
  • Tsuyoshi Miyazaki
  • ,
  • Tatsuro Tsuchida
  • ,
  • Takayuki Hirai
  • ,
  • Daisuke Sugita
  • ,
  • Shuji Watanabe
  • ,
  • Naoto Takeura
  • ,
  • Ai Yoshida
  • ,
  • Hidehiko Okazawa
  • ,
  • Hisatoshi Baba

7
2
開始ページ
96
終了ページ
103
記述言語
英語
掲載種別
Scientific Journal
DOI
10.4184/asj.2013.7.2.96

STUDY DESIGN: A retrospective study. PURPOSE: The aims of this study were to investigate the diagnostic value of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in PET/computed tomography (CT) in the evaluation of spinal metastatic lesions. OVERVIEW OF LITERATURE: Recent studies described limitations regarding how many lesions with abnormal (18)F-FDG PET findings in the bone show corresponding morphologic abnormalities. METHODS: The subjects for this retrospective study were 227 patients with primary malignant tumors, who were suspected of having spinal metastases. They underwent combined whole-body (18)F-FDG PET/CT scanning for evaluation of known neoplasms in the whole spine. (99m)Tc-methylene diphosphonate bone scan was performed within 2 weeks following PET/CT examinations. The final diagnosis of spinal metastasis was established by histopathological examination regarding bone biopsy or magnetic resonance imaging (MRI) findings, and follow-up MRI, CT and (18)F-FDG PET for extensively wide lesions with subsequent progression. RESULTS: From a total of 504 spinal lesions in 227 patients, 224 lesions showed discordant image findings. For 122 metastatic lesions with confirmed diagnosis, the sensitivity/specificity of bone scan and FDG PET were 84%/21% and 89%/76%, respectively. In 102 true-positive metastatic lesions, the bone scan depicted predominantly osteosclerotic changes in 36% and osteolytic changes in 19%. In 109 true-positive lesions of FDG PET, osteolytic changes were depicted predominantly in 38% while osteosclerotic changes were portrayed in 15%. CONCLUSIONS: (18)F-FDG PET in PET/CT could be used as a substitute for bone scan in the evaluation of spinal metastasis, especially for patients with spinal osteolytic lesions on CT.

リンク情報
DOI
https://doi.org/10.4184/asj.2013.7.2.96
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23741546
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669709