四童子好廣 (Yoshihiro Shidoji) - マイポータル

基本情報

所属: 長崎県立大学看護栄養学部栄養健康学科教授

学位: 保健学博士(東京大学)
医学博士(岐阜大学)
保健学修士(東京大学)

J-GLOBAL ID: 200901022448371672
researchmap会員ID: 1000290694

研究キーワード

研究分野

ライフサイエンス / 医化学 /

経歴

2008年4月 - 現在

長崎県立大学, 看護栄養学部, 教授
1999年4月 - 2008年3月

県立長崎シーボルト大学（現・長崎県立大学）, 教授

委員歴

2015年5月 - 現在

Nature Publishing Group, Editor (Chemical Biology) for Scientific Reports
2012年6月 - 2017年5月

日本ビタミン学会, 理事
1997年 - 2012年5月

日本ビタミン学会, 評議員
日本過酸化脂質・フリーラジカル学会, 評議員

受賞

2014年3月

Key Scientific Article, ヒト肝癌細胞におけるGGAによる変異p53の細胞質から核への移行, グローバルメディカルディスカバリー（カナダ）

四童子好廣

論文

Common SNP rs6564851 in the BCO1 Gene Affects the Circulating Levels of β-Carotene and the Daily Intake of Carotenoids in Healthy Japanese Women.

Yabuta S, Urata M, Wai Kun RY, Masaki M, Shidoji Y

PloS one 11(12) e0168857 2016年12月査読有り
Associations of Buccal Cell Telomere Length with Daily Intake of β-Carotene or α-Tocopherol Are Dependent on Carotenoid Metabolism-related Gene Polymorphisms in Healthy Japanese Adults.

四童子好廣

J Nutr Health Aging. 20(3) 267-274 2016年3月査読有り
Polyunsaturated Branched-Chain Fatty Acid Geranylgeranoic Acid Induces Unfolded Protein Response in Human Hepatoma Cells

Chieko Iwao, Yoshihiro Shidoji

PLOS ONE 10(7) e0132761 2015年7月査読有り
Measurement of lysine-specific demethylase-1 activity in the nuclear extracts by flow-injection based time-of-flight mass spectrometry

Chiharu Sakane, Hiromichi Ohta, Yoshihiro Shidoji

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION 56(2) 123-131 2015年3月査読有り
Upregulation of energy metabolism-related, p53-target TIGAR and SCO2 in HuH-7 cells with p53 mutation by geranylgeranoic acid treatment

Chieko Iwao, Yoshihiro Shidoji

BIOMEDICAL RESEARCH-TOKYO 36(6) 371-381 2015年査読有り
Dolichol biosynthesis: The occurrence of epoxy dolichol in skipjack tuna liver

Terumi Ishiguro, Yuiko Morita-Fujimura, Yoshihiro Shidoji, Hiroshi Sagami

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 453(2) 277-281 2014年10月査読有り
Induction of nuclear translocation of mutant cytoplasmic p53 by geranylgeranoic acid in a human hepatoma cell line

Chieko Iwao, Yoshihiro Shidoji

SCIENTIFIC REPORTS 4 4419 2014年3月査読有り
Inhibition of lysine-specific demethylase 1 by the acyclic diterpenoid geranylgeranoic acid and its derivatives

Chiharu Sakane, Takashi Okitsu, Akimori Wada, Hiroshi Sagami, Yoshihiro Shidoji

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 444(1) 24-29 2014年1月査読有り
CXCR4-Tropic, But Not CCR5-Tropic, Human Immunodeficiency Virus Infection Is Inhibited by the Lipid Raft-Associated Factors, Acyclic Retinoid Analogs, and Cholera Toxin B Subunit

Haruka Kamiyama, Katsura Kakoki, Sayuri Shigematsu, Mai Izumida, Yuka Yashima, Yuetsu Tanaka, Hideki Hayashi, Toshifumi Matsuyama, Hironori Sato, Naoki Yamamoto …

AIDS RESEARCH AND HUMAN RETROVIRUSES 29(2) 279-288 2013年2月査読有り
Rapid Downregulation of Cyclin D1 Induced by Geranylgeranoic Acid in Human Hepatoma Cells

Shohei Shimonishi, Takashi Muraguchi, Maiko Mitake, Chiharu Sakane, Kyoko Okamoto, Yoshihiro Shidoji

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 64(3) 473-480 2012年4月査読有り
Guidelines for the use and interpretation of assays for monitoring autophagy.

Daniel J Klionsky, Fabio C Abdalla, Hagai Abeliovich, Robert T Abraham, Abraham Acevedo-Arozena, Khosrow Adeli, Lotta Agholme, Maria Agnello, Patrizia Agostinis, Julio A Aguirre-Ghiso …

Autophagy 8(4) 445-544 2012年4月査読有り
Geranylgeraniol oxidase activity involved in oxidative formation of geranyl-geranoic acid in human hepatoma cells

Maiko Mitake, Yoshihiro Shidoji

BIOMEDICAL RESEARCH-TOKYO 33(1) 15-24 2012年2月査読有り
Association and interaction between dietary pattern and VEGF receptor-2 (VEGFR2) gene polymorphisms on blood lipids in Chinese Malaysian and Japanese adults

Roseline Wai Kuan Yap, Yoshihiro Shidoji, Wei Min Hon, Motofumi Masaki

ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION 21(2) 302-311 2012年査読有り
Association and interaction effect between VEGF receptor- 2 (VEGFR-2) gene polymorphisms and dietary pattern on blood uric acid in Malays and Indians

W. K. Roseline Yap, Y. Shidoji, W. M. Hon, M. Masaki

Malaysian Journal of Nutrition 18(3) 307-317 2012年査読有り
Induction of an incomplete autophagic response by cancer-preventive geranylgeranoic acid (GGA) in a human hepatoma-derived cell line

Kyoko Okamoto, Yoko Sakimoto, Katsuyuki Imai, Haruki Senoo, Yoshihiro Shidoji

BIOCHEMICAL JOURNAL 440(1) 63-71 2011年11月査読有り
Reversible upregulation of tropomyosin-related kinase receptor B by geranylgeranoic acid in human neuroblastoma SH-SY5Y cells.

Sakane C, Shidoji Y

Journal of neuro-oncology 104(3) 705-713 2011年9月査読有り
Polished rice as natural sources of cancer-preventing geranylgeranoic acid

Takashi Muraguchi, Kyoko Okamoto, Maiko Mitake, Hiroko Ogawa, Yoshihiro Shidoji

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION 49(1) 8-15 2011年7月査読有り
Interaction between VEGF Receptor-2 Gene Polymorphisms and Dietary Patterns on Blood Glucose and Lipid Levels in Chinese Malaysian Adults

Roseline Wai Kuan Yap, Yoshihiro Shidoji, Wei Min Hon, Motofumi Masaki

JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS 4(6) 309-321 2011年査読有り
Downregulation of trefoil factor 3 gene expression in the colon of the senescence-accelerated mouse (SAM)-P6 revealed by oligonucleotide microarray analysis

Takaaki Kawashima, Kyoko Okamoto, Takashi Muraguchi, Tsuneyuki Oku, Yoshihiro Shidoji

BIOMEDICAL RESEARCH-TOKYO 31(3) 169-175 2010年6月査読有り
Increase in Plasma Concentrations of Geranylgeranoic Acid after Turmeric Tablet Intake by Healthy Volunteers

Maiko Mitake, Hiroko Ogawa, Kazuo Uebaba, Yoshihiro Shidoji

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION 46(3) 252-258 2010年5月査読有り

もっとみる

MISC

Loss of molecular interaction between cytochrome c and cardiolipin due to lipid peroxidation

Y Shidoji, K Hayashi, S Komura, N Ohishi, K Yagi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 264(2) 343-347 1999年10月
Dissipation of mitochondrial membrane potential by exogenous phospholipid monohydroperoxide and protection against this effect by transfection of cells with phospholipid hydroperoxide glutathione peroxidase gene

K Yagi, Y Shidoji, S Komura, H Kojima, N Ohishi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 245(2) 528-533 1998年4月
Growth Suppression and Induction of Heat-shock Protein-70 by 9-cio β-Carotene in Cervical Dysplasia-derived Cells

Life Sciences 61(8) 839-845 1997年
Rapid Loss in the Mitochondrial Membrane Poteufid during Geranylgeranoic Acid-induced Apoptosis

Biochemical and Biophysical Research Communications 230(1) 58-63 1997年
Aberrant metabolism of retinoid X receptor proteins in human hepatocellular carcinoma

R MatsushimaNishiwaki, Y Shidoji, S Nishiwaki, T Yamada, H Moriwaki, Y Muto

MOLECULAR AND CELLULAR ENDOCRINOLOGY 121(2) 179-190 1996年8月
Limited degradation of retinoid x receptor by calpain

R MatsushimaNishiwaki, Y Shidoji, S Nishiwaki, H Moriwaki, Y Muto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 225(3) 946-951 1996年8月
Apoptosis in Human Hepatoma Cell Line induced by 4,5-didehydro Geranylgeranoic Acid (acyclic retiwoid)via Down-regulation of Transforming Growth Facter-α

Bichemical and Biophysical Research Communications 219(1) 100-104 1996年
RETINOID AGONIST ACTIVITIES OF SYNTHETIC GERANYL GERANOIC ACID-DERIVATIVES

H ARAKI, Y SHIDOJI, Y YAMADA, H MORIWAKI, Y MUTO

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 209(1) 66-72 1995年4月
Growth Retardation in Human Cervical Dysplasia-derived Cell Lines by β-Carotene through Down-regulation of Epidermal Growth Factor Receptor

America Journal of Clinical Nutrition 62(Suppl.1) 15355-15405 1995年

書籍等出版物

Diterpenoids Types, Function and Research

四童子好廣 (担当:共著, 範囲:第４章ゲラニルゲラノイン酸の生物学)

ノヴァ 2017年1月

所属学協会

Works(作品等)

共同研究・競争的資金等の研究課題

栄養素による脳の老化制御に関する研究

2003年 - 2010年
非環式レチノイドの抗腫瘍作用のメカニズムに関する研究

1999年 - 2010年
Studies on Nutritional Control of Brain Aging

1999年 - 2010年
遺伝子多型と代謝応答に関する研究

2003年 - 2007年
Studies on single nucleotide polymorphisms and metabolic responses

2003年 - 2007年
天然物発癌抑制剤の探索
Search for Natural Anti-carcinogenic Agents
Study on Molecular Mechanism underlying Anti-tumor Action of Acyclic Retinoids