Mineo Kurokawa - My portal

Profile Information

Affiliation: Professor, Faculty of Medicine University Hospital, Heamatology and Oncology, The University of Tokyo

Degree: (BLANK)(The University of Tokyo)

J-GLOBAL ID: 200901006742252503
researchmap Member ID: 1000292110

External link: http://www.h.u-tokyo.ac.jp/hematology/

Research Interests

Research Areas

Life sciences / Hematology and oncology /

Research History

2008 - Present

Faculty of Medicine University Hospital, Department of Cell and Gene Therapy, The University of Tokyo
2005 - Present

Heamatology and Oncology, Faculty of Medicine University Hospital, The University of Tokyo
Apr, 2019 - Mar, 2021

Graduate School of Medicine, The University of Tokyo
Apr, 2017 - Mar, 2019

Faculty of Medicine University Hospital, The University of Tokyo
Apr, 2017 - Mar, 2019

Faculty of Medicine University Hospital, The University of Tokyo
Apr, 2017 - Mar, 2019

Faculty of Medicine University Hospital, The University of Tokyo
Apr, 2017 - Mar, 2019

Faculty of Medicine University Hospital, The University of Tokyo
Apr, 2014 - Mar, 2019

Faculty of Medicine University Hospital, The University of Tokyo
Apr, 2013 - Mar, 2014

Faculty of Medicine University Hospital, The University of Tokyo
2004 - 2005

東京大学医学部付属病院血液・腫瘍内科講師
1999 - 2003

東京大学医学部付属病院血液・腫瘍内科助手

Education

- 1995

The University of Tokyo
- 1995

Graduate School, Division of Medical Sciences, The University of Tokyo
- 1990

School of Medicine, Faculty of Medicine, The University of Tokyo
- 1990

Faculty of Medicine, The University of Tokyo

Committee Memberships

Awards

Papers

100

Adult T-cell leukemia-lymphoma with neurolymphomatosis successfully controlled by valemetostat: a case report and review of literature.

Masanori Toho, Megumi Yasunaga, Yasutaka Masuda, Arika Shimura, Yosuke Masamoto, Kensyo Sumi, Kyosuke Muramatsu, Masahiko Tsujita, Shuichiro Mitsuchi, Reo Yoshioka …

Leukemia & lymphoma, 1-5, Jul 25, 2024
Prognostic factors of idiopathic hypereosinophilic syndrome: A nationwide survey in Japan.

Akira Honda, Yasutaka Masuda, Yu Oyama, Kensuke Matsuda, Hideaki Mizuno, Akiko M Saito, Yoshio Katayama, Norio Komatsu, Kazuhiro Toyama, Mineo Kurokawa

British journal of haematology, May 26, 2024
Long-term remission after upfront autologous hematopoietic stem cell transplant for CD5+ diffuse large-B cell lymphoma.

Yosuke Masamoto, Akira Honda, Aya Shinozaki-Ushiku, Tetsuo Ushiku, Mineo Kurokawa

Journal of chemotherapy (Florence, Italy), 1-9, Apr 23, 2024
A key to engineering natural killer cells to attack acute myeloid leukemia.

Yosuke Masamoto, Mineo Kurokawa

Haematologica, 109(4) 1032-1034, Apr 1, 2024
Isolated massive pleural effusion as a manifestation of chronic graft versus host disease successfully treated with corticosteroid.

Yasutaka Masuda, Sho Yamazaki, Akira Honda, Yosuke Masamoto, Mineo Kurokawa

Annals of hematology, 103(4) 1403-1407, Apr, 2024
Recurrent DDX41 mutation in very late relapse after allogeneic stem cell transplantation

Yasuhiro Kambara, Daichi Sadato, Takashi Toya, Akira Honda, Seiko Kato, Chizuko Hirama, Kyoko Haraguchi, Hiroaki Shimizu, Yuho Najima, Takeshi Kobayashi …

Leukemia, Jan 18, 2024
Myeloid sarcoma and pathological fracture: a case report and review of literature.

Sho Takeyasu, Ken Morita, Seitaro Saito, Masanori Toho, Takashi Oyama, Takafumi Obo, Kazuki Taoka, Arika Shimura, Hiroaki Maki, Eisuke Shibata …

International journal of hematology, Sep 14, 2023
Recurrent bilateral adrenal infarction with myelodysplastic/myeloproliferative neoplasm-unclassifiable (MDS/MPN-U): a case report.

Yoshitomo Hoshino, Katsunori Manaka, Junichiro Sato, Yui Asatsuma, Hirofumi Horikoshi, Maki Takeuchi, Nobuaki Ito, Megumi Fujita, Megumi Yasunaga, Kensuke Matsuda …

BMC endocrine disorders, 23(1) 128-128, Jun 5, 2023
Expansion of large granular lymphocytes after autologous hematopoietic stem cell transplantation.

Mina Yoshida, Kensuke Matsuda, Kazuki Taoka, Akira Honda, Hiroaki Maki, Yosuke Masamoto, Masahiro Jona, Masako Nishikawa, Yutaka Yatomi, Mineo Kurokawa

International journal of hematology, 117(6) 839-844, Jun, 2023
Favorable outcome of hematopoietic stem cell transplantation in late-onset Krabbe disease.

Akihiko Mitsutake, Takashi Matsukawa, Atsushi Iwata, Hiroyuki Ishiura, Jun Mitsui, Harushi Mori, Takashi Toya, Akira Honda, Mineo Kurokawa, Norio Sakai …

Brain & development, Apr 18, 2023
Acute pancreatitis as the initial manifestation of acute myeloid leukemia with chromosome 16 rearrangements

Hidehito Fukushima, Ken Morita, Masako Ikemura, Mariko Tanaka, Yudai Nakai, Hiroaki Maki, Tatsunori Suzuki, Suguru Mizuno, Yousuke Nakai, Mineo Kurokawa

International Journal of Hematology, Mar 25, 2023
Verification study on the catheterization of an upper arm vein using the new long peripheral intravenous catheter to reduce catheter failure incidence: A randomized controlled trial.

Ryoko Murayama, Mari Abe-Doi, Yosuke Masamoto, Kosuke Kashiwabara, Chieko Komiyama, Hiromi Sanada, Mineo Kurokawa

Drug discoveries & therapeutics, 17(1) 52-59, Mar 11, 2023
Daratumumab plus lenalidomide and dexamethasone for relapsed POEMS syndrome with bone plasmacytoma harboring 17p deletion.

Takashi Oyama, Kazuki Taoka, Akira Chiba, Yosuke Masamoto, Masako Ikemura, Akira Honda, Hiroaki Maki, Mineo Kurokawa

International journal of hematology, 117(3) 463-467, Mar, 2023
Isolated relapse of plasma cell leukemia in the central nervous systems: a case report and literature review.

Takafumi Obo, Ken Morita, Yutaro Sumida, Kumi Nakazaki-Watadani, Masako Ikemura, Koichiro Yasaka, Osamu Abe, Hirokazu Takami, Shunsaku Takayanagi, Shota Tanaka …

International journal of hematology, 118(1) 135-140, Feb 3, 2023
Obinutuzumab and reduced bendamustine is effective for elderly patients with follicular lymphoma.

Yosuke Masamoto, Arika Shimura, Akira Honda, Kazuki Taoka, Hiroaki Maki, Mineo Kurokawa

Annals of hematology, 102(1) 243-244, Jan, 2023
Severe autoimmune pancytopenia after autologous hematopoietic stem cell transplantation for Hodgkin lymphoma.

Yuta Fukui, Akira Honda, Hirofumi Takano, Takafumi Obo, Hideaki Mizuno, Yosuke Masamoto, Mineo Kurokawa

Journal of clinical and experimental hematopathology : JCEH, 62(4) 217-221, Dec 28, 2022
Toxic shock like syndrome caused by Streptococcus agalactiae bacteremia during treatment for multiple myeloma.

Mina Yoshida, Kensuke Matsuda, Kiyora Endo, Akira Honda, Hiroaki Maki, Kazuki Taoka, Yosuke Masamoto, Yuji Wakimoto, Daisuke Jubishi, Kyoji Moriya …

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Dec 10, 2022
Prompt Initiation of Conventional Chemotherapy to Avoid Early Death in Patients with Newly Diagnosed Acute Promyelocytic Leukemia.

Kensuke Matsuda, Takashi Oyama, Hiroaki Maki, Kumi Nakazaki, Megumi Yasunaga, Akira Honda, Yosuke Masamoto, Mineo Kurokawa

Internal medicine (Tokyo, Japan), Dec 7, 2022
Clinical usefulness of a novel classification of T cell distribution patterns in the tumor microenvironment of follicular lymphoma to detect transformation.

Hirotaka Miyashita, Kazuki Taoka, Ayako Kume, Aya Ushiku, Tetsuo Ushiku, Kazuhiro Toyama, Mineo Kurokawa

Annals of hematology, 101(11) 2477-2483, Nov, 2022
EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistance and immune-suppressive environment.

Yosuke Masamoto, Akira Chiba, Hideaki Mizuno, Toshiya Hino, Hiroki Hayashida, Tomohiko Sato, Masashige Bando, Katsuhiko Shirahige, Mineo Kurokawa

Blood advances, 7(8) 1577-1593, Oct 21, 2022

Misc.

同種造血幹細胞移植後に生じたAchromobacter xylosoxidansによる蜂窩織炎

大山悠, 安永愛, 本田晃, 牧宏彰, 正本庸介, 小林竜也, 若林義賢, 奥川周, 森屋恭爾, 黒川峰夫

臨床血液, 62(6) 672-672, Jun, 2021
食後のインスリン・LPSシグナルによるマクロファージのIL-10発現を介した糖新生抑制メカニズム

戸田郷太郎, 添田光太郎, 荒川直子, 升田紫, 小林直樹, 生島芳子, 粟澤元晴, 正本庸介, 諏訪内浩紹, 泉田欣彦 …

糖尿病, 64(Suppl.1) YIA-2), May, 2021
Human Germline HLTF E259K Mutation Identified in Familial MDS Patients Accumulates DNA Damage through Impaired PCNA Polyubiquitination

Kensuke Takaoka, Masahito Kawazu, Junji Koya, Akihide Yoshimi, Yosuke Masamoto, MD PhD, Hiroaki Maki, Takashi Toya, Takashi Kobayashi, Yasuhito Nannya …

130 4238, Dec, 2017 Peer-reviewed
The significance of free light chain measurements in the diagnosis of myelomatous pleural effusion

Ayato Tsukamoto, Yumiko Yoshiki, Sho Yamazaki, Keiki Kumano, Fumihiko Nakamura, Mineo Kurokawa

Annals of Hematology, 93(3) 507-508, Mar, 2014
思春期/成人大脳型副腎白質ジストロフィーに対する造血幹細胞移植の臨床的効果の検討

松川敬志, 山本知孝, 熊野恵城, 市川幹, 高橋祐二, 石浦浩之, 三井純, 田中真生, 後藤順, 黒川峰夫 …

日本神経学会学術大会プログラム・抄録集, 53(12) 1519-1519, Dec, 2013
思春期/成人大脳型副腎白質ジストロフィーに対する造血幹細胞移植の臨床的効果に関する検討

松川敬志, 山本知孝, 瀬尾幸子, 熊野恵城, 市川幹, 高橋祐二, 石浦浩之, 三井純, 後藤順, 黒川峰夫 …

臨床神経学, 52(12) 1401-1401, Dec, 2012
AML1/RUNX1 FUNCTIONS AS A CYTOPLASMIC ATTENUATOR OF NF-KB SIGNALING IN THE REPRESSION OF MYELOID TUMORS

M. Nakagawa, M. Shimabe, S. Arai, N. Watanabeo-Okochi, A. Yoshimi, N. Nishimoto, M. Ichikawa, Y. Nannya, Y. Imai, M. Kurokawa

EXPERIMENTAL HEMATOLOGY, 38(9) S81-S81, Sep, 2010
Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells

Susumu Goyama, Go Yamamoto, Munetake Shimabe, Tomohiko Sato, Motoshi Ichikawa, Seishi Ogawa, Shigeru Chiba, Mineo Kurokawa

CELL STEM CELL, 3(2) 207-220, Aug, 2008
AML1 is required for megakaryocytic maturation in adult hematopoiesis.

M Ichikawa, T Asai, T Saito, S Seo, G Yamamoto, T Yamagata, Yamazaki, I, M Kurokawa, K Mitani, H Hirai

BLOOD, 100(11) 130A-131A, Nov, 2002
The Evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death

M Kurokawa, K Mitani, T Yamagata, T Takahashi, K Izutsu, S Ogawa, T Moriguchi, E Nishida, Y Yazaki, H Hirai

EMBO JOURNAL, 19(12) 2958-2968, Jun, 2000 Peer-reviewed
The AML1/ETO(MTG8) and AML1/Evi-1 leukemia-associated chimeric oncoproteins accumulate PEBP2 beta(CBF beta) in the nucleus more efficiently than wild-type AML1

K Tanaka, T Tanaka, M Kurokawa, Y Imai, S Ogawa, K Mitani, Y Yazaki, H Hirai

BLOOD, 91(5) 1688-1699, Mar, 1998
The t(3 ; 21)fusion product, AML1/Evi-1, interacts with Smad3 and blocks TGF-β-mediated growth inhibition of myeloid cells

Blood, 92 4003-4012, 1998 Peer-reviewed
The AML1/ETO(MTG8) and AML1/EVI-1 leukemia-associated chimeric oncoproteins accumulate PEBP2 beta(CBF beta) in the nucleus more efficiently than wild-type AML1.

K Tanaka, T Tanaka, M Kurokawa, Y Imai, S Ogawa, SW Hiebert, K Mitani, Y Yazaki, H Hirai

BLOOD, 88(10) 2188-2188, Nov, 1996
Increased Evi-1 expression is frequently observed in blastic crisis of chronic myelocytic leukemia

S Ogawa, M Kurokawa, T Tanaka, K Tanaka, A Hangaishi, K Mitani, N Kamada, Y Yazaki, H Hirai

LEUKEMIA, 10(5) 788-794, May, 1996
Overexpression of the AML1 proto-oncoprotein in NIH3T3 cells leads to neoplastic transformation depending on the DNA-binding and transactivational potencies

M Kurokawa, T Tanaka, K Tanaka, S Ogawa, K Mitani, Y Yazaki, H Hirai

ONCOGENE, 12(4) 883-892, Feb, 1996 Peer-reviewed
A conserved cysteine residue in the runt homology domain of AML1 is required for the DNA-binding ability and the transforming activity on fibroblasts.

J Biol Chem, 271(28) 16870-16876, 1996 Peer-reviewed
DUAL FUNCTIONS OF THE AML1/EVI-1 CHIMERIC PROTEIN IN THE MECHANISM OF LEUKEMOGENESIS IN T(3-21) LEUKEMIAS

T TANAKA, K MITANI, M KUROKAWA, S OGAWA, K TANAKA, J NISHIDA, Y YAZAKI, Y SHIBATA, H HIRAI

MOLECULAR AND CELLULAR BIOLOGY, 15(5) 2383-2392, May, 1995
The AML1/Evi-1 fusion protein in the t(3 : 21) translocation exhibits transforming activity on Ratl fibroblasts with dependence on the Evi-1 sequence. (共著)

Oncogene, 11 833-840, 1995 Peer-reviewed
HOMOZYGOUS LOSS OF THE CYCLIN-DEPENDENT KINASE-4 INHIBITOR (CDK4I-P16) GENE IN HUMAN LEUKEMIAS

S OGAWA, A HANGAISHI, N SATO, M TAKATOKU, N HIRANO, K TANAKA, M KUROKAWA, T TANAKA, K MITANI, Y YAZAKI …

BLOOD, 84(10) A296-A296, Nov, 1994
HOMOZYGOUS LOSS OF THE CYCLIN-DEPENDENT KINASE 4-INHIBITOR (P16) GENE IN HUMAN LEUKEMIAS

S OGAWA, N HIRANO, N SATO, T TAKAHASHI, A HANGAISHI, K TANAKA, M KUROKAWA, T TANAKA, K MITANI, Y YAZAKI …

BLOOD, 84(8) 2431-2435, Oct, 1994

Professional Memberships

Research Projects

白血病の非ゲノム複製機構に着目した新規治療標的の探索

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2022 - Mar, 2024

黒川峰夫
難治性白血病の制御機構解明に基づく革新的治療法の開発

科学研究費助成事業, 基盤研究(A), 日本学術振興会, Apr, 2021 - Mar, 2024

黒川峰夫
Study for mechanisms of emergence of leukemia cell

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2022

Kurokawa Mineo
Elucidation of pathogenesis and novel therapeutics for refractory leukemias

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

KUROKAWA MINEO
白血病幹細胞の維持におけるオートファジーの機能的役割の解明

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2016 - Mar, 2018

黒川峰夫
detection of essential epigenetic marks for leukemogenesis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2017

Kurokawa Mineo
骨髄異形成症候群の造血抑制における、細胞競合の役割の解明

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2015 - Mar, 2017

黒川峰夫
Control of cell fate decision in the cells differentiating to multiple pathways in a step-by-step fashion

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2010 - Mar, 2016

KITAMURA Toshio, KAWAMOTO Hiroshi, NAKANISHI Makoto, INABA Toshiya, MIYAJIMA Atsushi, IKEDA Kyoji, USHIJIMA Toshikazu, KUROKAWA Mineo, SASAKI Hiroyuki
Screening of factors regulating refractory leukemia using genome editting

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2015

KUROKAWA MINEO
Establishment of a platform for elucidation of molecular pathogenesis of leukemia and antileukemia therapy based on integrated pathway analysis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

KUROKAWA MINEO
Elucidation of mechanisms of myelodysplastic syndrome progression by RNAi screening.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2014

KUROKAWA Mineo, KATAOKA Keisuke
白血病幹細胞の維持機構の解明と治療標的の同定

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2011 - Mar, 2013

黒川峰夫
Pathophysiological elucidation of refractory leukemias with the genetic analyses at the single-cell level

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2012 - 2012

KUROKAWA Mineo
Elucidation of molecular pathogenesis and therapeutic targets for refractory hematological malignancies

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (S), Japan Society for the Promotion of Science, 2007 - 2011

KUROKAWA Mineo
AML1の機能不全による造血異常と白血病発症機構の解明

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2006 - 2007

黒川峰夫, 河津正人
Comprehensive analysis of oncogenic transcriptional factor Evi-1.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2005 - 2006

KUROKAWA Mineo, HANGAISHI Akira, IZUTSU Koji, GOYAMA Susumu
造血幹細胞の可塑性の制御と再生医療への応用

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2005 - 2005

黒川峰夫, 浅井隆司
Functional analysis of Blimp-1

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005

HANGAISHI Akira, KUROKAWA Mineo, CHIBA Shigeru, OGAWA Seishi, KANDA Yoshinibu
造血系の構築および悪性化を制御するマスター遺伝子の同定

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2004 - 2004

黒川峰夫, 浅井隆司
AML1による造血細胞の制御および悪性化機構の網羅的解析

科学研究費助成事業, 若手研究(A), 日本学術振興会, 2003 - 2004

黒川峰夫