Mineo Kurokawa

Profile Information

Affiliation: Professor, Faculty of Medicine University Hospital, Heamatology and Oncology, The University of Tokyo

Degree: (BLANK)(The University of Tokyo)

J-GLOBAL ID: 200901006742252503
researchmap Member ID: 1000292110

External link: http://www.h.u-tokyo.ac.jp/hematology/

Research Interests

Research Areas

Life sciences / Hematology and oncology /

Research History

2008 - Present

Faculty of Medicine University Hospital, Department of Cell and Gene Therapy, The University of Tokyo
2005 - Present

Heamatology and Oncology, Faculty of Medicine University Hospital, The University of Tokyo
Apr, 2019 - Mar, 2021

Graduate School of Medicine, The University of Tokyo
Apr, 2017 - Mar, 2019

Faculty of Medicine University Hospital, The University of Tokyo
Apr, 2017 - Mar, 2019

Faculty of Medicine University Hospital, The University of Tokyo
Apr, 2017 - Mar, 2019

Faculty of Medicine University Hospital, The University of Tokyo
Apr, 2017 - Mar, 2019

Faculty of Medicine University Hospital, The University of Tokyo
Apr, 2014 - Mar, 2019

Faculty of Medicine University Hospital, The University of Tokyo
Apr, 2013 - Mar, 2014

Faculty of Medicine University Hospital, The University of Tokyo
2004 - 2005

東京大学医学部付属病院血液・腫瘍内科講師
1999 - 2003

東京大学医学部付属病院血液・腫瘍内科助手

Education

- 1995

The University of Tokyo
- 1995

Graduate School, Division of Medical Sciences, The University of Tokyo
- 1990

School of Medicine, Faculty of Medicine, The University of Tokyo
- 1990

Faculty of Medicine, The University of Tokyo

Committee Memberships

Awards

Papers

Myeloid sarcoma and pathological fracture: a case report and review of literature.

Sho Takeyasu, Ken Morita, Seitaro Saito, Masanori Toho, Takashi Oyama, Takafumi Obo, Kazuki Taoka, Arika Shimura, Hiroaki Maki, Eisuke Shibata …

International journal of hematology, Sep 14, 2023
Recurrent bilateral adrenal infarction with myelodysplastic/myeloproliferative neoplasm-unclassifiable (MDS/MPN-U): a case report.

Yoshitomo Hoshino, Katsunori Manaka, Junichiro Sato, Yui Asatsuma, Hirofumi Horikoshi, Maki Takeuchi, Nobuaki Ito, Megumi Fujita, Megumi Yasunaga, Kensuke Matsuda …

BMC endocrine disorders, 23(1) 128-128, Jun 5, 2023
Expansion of large granular lymphocytes after autologous hematopoietic stem cell transplantation.

Mina Yoshida, Kensuke Matsuda, Kazuki Taoka, Akira Honda, Hiroaki Maki, Yosuke Masamoto, Masahiro Jona, Masako Nishikawa, Yutaka Yatomi, Mineo Kurokawa

International journal of hematology, 117(6) 839-844, Jun, 2023
Favorable outcome of hematopoietic stem cell transplantation in late-onset Krabbe disease.

Akihiko Mitsutake, Takashi Matsukawa, Atsushi Iwata, Hiroyuki Ishiura, Jun Mitsui, Harushi Mori, Takashi Toya, Akira Honda, Mineo Kurokawa, Norio Sakai …

Brain & development, Apr 18, 2023
Acute pancreatitis as the initial manifestation of acute myeloid leukemia with chromosome 16 rearrangements

Hidehito Fukushima, Ken Morita, Masako Ikemura, Mariko Tanaka, Yudai Nakai, Hiroaki Maki, Tatsunori Suzuki, Suguru Mizuno, Yousuke Nakai, Mineo Kurokawa

International Journal of Hematology, Mar 25, 2023
Daratumumab plus lenalidomide and dexamethasone for relapsed POEMS syndrome with bone plasmacytoma harboring 17p deletion.

Takashi Oyama, Kazuki Taoka, Akira Chiba, Yosuke Masamoto, Masako Ikemura, Akira Honda, Hiroaki Maki, Mineo Kurokawa

International journal of hematology, 117(3) 463-467, Mar, 2023
Isolated relapse of plasma cell leukemia in the central nervous systems: a case report and literature review.

Takafumi Obo, Ken Morita, Yutaro Sumida, Kumi Nakazaki-Watadani, Masako Ikemura, Koichiro Yasaka, Osamu Abe, Hirokazu Takami, Shunsaku Takayanagi, Shota Tanaka …

International journal of hematology, 118(1) 135-140, Feb 3, 2023
Toxic shock like syndrome caused by Streptococcus agalactiae bacteremia during treatment for multiple myeloma.

Mina Yoshida, Kensuke Matsuda, Kiyora Endo, Akira Honda, Hiroaki Maki, Kazuki Taoka, Yosuke Masamoto, Yuji Wakimoto, Daisuke Jubishi, Kyoji Moriya …

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Dec 10, 2022
Prompt Initiation of Conventional Chemotherapy to Avoid Early Death in Patients with Newly Diagnosed Acute Promyelocytic Leukemia.

Kensuke Matsuda, Takashi Oyama, Hiroaki Maki, Kumi Nakazaki, Megumi Yasunaga, Akira Honda, Yosuke Masamoto, Mineo Kurokawa

Internal medicine (Tokyo, Japan), Dec 7, 2022
Clinical usefulness of a novel classification of T cell distribution patterns in the tumor microenvironment of follicular lymphoma to detect transformation.

Hirotaka Miyashita, Kazuki Taoka, Ayako Kume, Aya Ushiku, Tetsuo Ushiku, Kazuhiro Toyama, Mineo Kurokawa

Annals of hematology, 101(11) 2477-2483, Nov, 2022
EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistance and immune-suppressive environment.

Yosuke Masamoto, Akira Chiba, Hideaki Mizuno, Toshiya Hino, Hiroki Hayashida, Tomohiko Sato, Masashige Bando, Katsuhiko Shirahige, Mineo Kurokawa

Blood advances, 7(8) 1577-1593, Oct 21, 2022
Clinical characteristics of steroid-responsive but dependent chronic graft-versus-host disease: a multicenter retrospective analysis.

Takashi Oyama, Kensuke Matsuda, Akira Honda, Hiroaki Maki, Yosuke Masamoto, Daisuke Murakami, Takashi Toya, Masatoshi Sakurai, Keisuke Kataoka, Noriko Doki …

International journal of hematology, 117(2) 260-268, Oct 17, 2022
Long-term follow-up of central nervous system relapse in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy.

Takashi Oyama, Kensuke Matsuda, Akira Honda, Megumi Yasunaga, Kumi Nakazaki, Hiroaki Maki, Yosuke Masamoto, Mineo Kurokawa

Leukemia & lymphoma, 63(14) 1-4, Oct 12, 2022
Independent origins of fetal liver haematopoietic stem and progenitor cells.

Tomomasa Yokomizo, Takako Ideue, Saori Morino-Koga, Cheng Yong Tham, Tomohiko Sato, Naoki Takeda, Yoshiaki Kubota, Mineo Kurokawa, Norio Komatsu, Minetaro Ogawa …

Nature, 609(7928) 779-784, Sep 14, 2022
Discordant lymphomas of classic Hodgkin lymphoma and peripheral T-cell lymphoma following dupilumab treatment for atopic dermatitis.

Kumi Nakazaki, Mina Yoshida, Yosuke Masamoto, Aya Shinozaki-Ushiku, Masako Ikemura, Teruyoshi Hisamoto, Megumi Yasunaga, Shinichi Sato, Mineo Kurokawa

International journal of hematology, 116(3) 446-452, Sep, 2022
A case of JAK2 V617F positive essential thrombocythemia successfully controlled by imatinib mesylate.

Kazutoshi Ebisawa, Yosuke Masamoto, Koichi Yagi, Mineo Kurokawa

Annals of hematology, Aug 6, 2022
Severe infections and renal dysfunction during immunosuppressive therapy with cyclosporine A for aplastic anemia.

Daisuke Murakami, Kensuke Matsuda, Akira Honda, Yosuke Masamoto, Mineo Kurokawa

International journal of hematology, Jun 24, 2022
A Case of Bing-Neel Syndrome Successfully Treated with Tirabrutinib.

Takashi Oyama, Kazuki Taoka, Akira Chiba, Kensuke Matsuda, Hiroaki Maki, Yosuke Masamoto, Mineo Kurokawa

Internal medicine (Tokyo, Japan), 61(23) 3575-3579, May 14, 2022
豊富なアズール好性顆粒を有した混合表現型急性白血病の1症例

寺島道子, 常名政弘, 宮脇綾, 高橋恵, 辻井亜弥, 西川真子, 安永愛, 正本庸介, 黒川峰夫, 矢冨裕

Cytometry Research, 32(Suppl.) 30-30, May, 2022
抗IL-4/13抗体デュピルマブ投与後に末梢性T細胞リンパ腫と古典的ホジキンリンパ腫を合併した症例

吉田澪奈, 中崎久美, 正本庸介, 牛久綾, 池村雅子, 久本晃義, 安永愛, 佐藤伸一, 黒川峰夫

臨床血液, 63(5) 500-501, May, 2022

Misc.

同種造血幹細胞移植後に生じたAchromobacter xylosoxidansによる蜂窩織炎

大山悠, 安永愛, 本田晃, 牧宏彰, 正本庸介, 小林竜也, 若林義賢, 奥川周, 森屋恭爾, 黒川峰夫

臨床血液, 62(6) 672-672, Jun, 2021
食後のインスリン・LPSシグナルによるマクロファージのIL-10発現を介した糖新生抑制メカニズム

戸田郷太郎, 添田光太郎, 荒川直子, 升田紫, 小林直樹, 生島芳子, 粟澤元晴, 正本庸介, 諏訪内浩紹, 泉田欣彦 …

糖尿病, 64(Suppl.1) YIA-2), May, 2021
Human Germline HLTF E259K Mutation Identified in Familial MDS Patients Accumulates DNA Damage through Impaired PCNA Polyubiquitination

Kensuke Takaoka, Masahito Kawazu, Junji Koya, Akihide Yoshimi, Yosuke Masamoto, MD PhD, Hiroaki Maki, Takashi Toya, Takashi Kobayashi, Yasuhito Nannya …

130 4238, Dec, 2017 Peer-reviewed
思春期/成人大脳型副腎白質ジストロフィーに対する造血幹細胞移植の臨床的効果の検討

松川敬志, 山本知孝, 熊野恵城, 市川幹, 高橋祐二, 石浦浩之, 三井純, 田中真生, 後藤順, 黒川峰夫 …

日本神経学会学術大会プログラム・抄録集, 53(12) 1519-1519, Dec, 2013
思春期/成人大脳型副腎白質ジストロフィーに対する造血幹細胞移植の臨床的効果に関する検討

松川敬志, 山本知孝, 瀬尾幸子, 熊野恵城, 市川幹, 高橋祐二, 石浦浩之, 三井純, 後藤順, 黒川峰夫 …

臨床神経学, 52(12) 1401-1401, Dec, 2012
AML1/RUNX1 FUNCTIONS AS A CYTOPLASMIC ATTENUATOR OF NF-KB SIGNALING IN THE REPRESSION OF MYELOID TUMORS

M. Nakagawa, M. Shimabe, S. Arai, N. Watanabeo-Okochi, A. Yoshimi, N. Nishimoto, M. Ichikawa, Y. Nannya, Y. Imai, M. Kurokawa

EXPERIMENTAL HEMATOLOGY, 38(9) S81-S81, Sep, 2010
Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells

Susumu Goyama, Go Yamamoto, Munetake Shimabe, Tomohiko Sato, Motoshi Ichikawa, Seishi Ogawa, Shigeru Chiba, Mineo Kurokawa

CELL STEM CELL, 3(2) 207-220, Aug, 2008
AML1 is required for megakaryocytic maturation in adult hematopoiesis.

M Ichikawa, T Asai, T Saito, S Seo, G Yamamoto, T Yamagata, Yamazaki, I, M Kurokawa, K Mitani, H Hirai

BLOOD, 100(11) 130A-131A, Nov, 2002
The Evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death

M Kurokawa, K Mitani, T Yamagata, T Takahashi, K Izutsu, S Ogawa, T Moriguchi, E Nishida, Y Yazaki, H Hirai

EMBO JOURNAL, 19(12) 2958-2968, Jun, 2000 Peer-reviewed
The AML1/ETO(MTG8) and AML1/Evi-1 leukemia-associated chimeric oncoproteins accumulate PEBP2 beta(CBF beta) in the nucleus more efficiently than wild-type AML1

K Tanaka, T Tanaka, M Kurokawa, Y Imai, S Ogawa, K Mitani, Y Yazaki, H Hirai

BLOOD, 91(5) 1688-1699, Mar, 1998
The t(3 ; 21)fusion product, AML1/Evi-1, interacts with Smad3 and blocks TGF-β-mediated growth inhibition of myeloid cells

Blood, 92 4003-4012, 1998 Peer-reviewed
The AML1/ETO(MTG8) and AML1/EVI-1 leukemia-associated chimeric oncoproteins accumulate PEBP2 beta(CBF beta) in the nucleus more efficiently than wild-type AML1.

K Tanaka, T Tanaka, M Kurokawa, Y Imai, S Ogawa, SW Hiebert, K Mitani, Y Yazaki, H Hirai

BLOOD, 88(10) 2188-2188, Nov, 1996
Increased Evi-1 expression is frequently observed in blastic crisis of chronic myelocytic leukemia

S Ogawa, M Kurokawa, T Tanaka, K Tanaka, A Hangaishi, K Mitani, N Kamada, Y Yazaki, H Hirai

LEUKEMIA, 10(5) 788-794, May, 1996
Overexpression of the AML1 proto-oncoprotein in NIH3T3 cells leads to neoplastic transformation depending on the DNA-binding and transactivational potencies

M Kurokawa, T Tanaka, K Tanaka, S Ogawa, K Mitani, Y Yazaki, H Hirai

ONCOGENE, 12(4) 883-892, Feb, 1996 Peer-reviewed
A conserved cysteine residue in the runt homology domain of AML1 is required for the DNA-binding ability and the transforming activity on fibroblasts.

J Biol Chem, 271(28) 16870-16876, 1996 Peer-reviewed
DUAL FUNCTIONS OF THE AML1/EVI-1 CHIMERIC PROTEIN IN THE MECHANISM OF LEUKEMOGENESIS IN T(3-21) LEUKEMIAS

T TANAKA, K MITANI, M KUROKAWA, S OGAWA, K TANAKA, J NISHIDA, Y YAZAKI, Y SHIBATA, H HIRAI

MOLECULAR AND CELLULAR BIOLOGY, 15(5) 2383-2392, May, 1995
The AML1/Evi-1 fusion protein in the t(3 : 21) translocation exhibits transforming activity on Ratl fibroblasts with dependence on the Evi-1 sequence. (共著)

Oncogene, 11 833-840, 1995 Peer-reviewed
HOMOZYGOUS LOSS OF THE CYCLIN-DEPENDENT KINASE-4 INHIBITOR (CDK4I-P16) GENE IN HUMAN LEUKEMIAS

S OGAWA, A HANGAISHI, N SATO, M TAKATOKU, N HIRANO, K TANAKA, M KUROKAWA, T TANAKA, K MITANI, Y YAZAKI …

BLOOD, 84(10) A296-A296, Nov, 1994
HOMOZYGOUS LOSS OF THE CYCLIN-DEPENDENT KINASE 4-INHIBITOR (P16) GENE IN HUMAN LEUKEMIAS

S OGAWA, N HIRANO, N SATO, T TAKAHASHI, A HANGAISHI, K TANAKA, M KUROKAWA, T TANAKA, K MITANI, Y YAZAKI …

BLOOD, 84(8) 2431-2435, Oct, 1994

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