MISC

1998年8月

Merkel cell carcinoma, Bowen's disease and chronic occupational arsenic poisoning

BRITISH JOURNAL OF DERMATOLOGY
  • D Tsuruta
  • ,
  • T Hamada
  • ,
  • K Mochida
  • ,
  • K Nakagawa
  • ,
  • H Kobayashi
  • ,
  • M Ishii

139
2
開始ページ
291
終了ページ
294
記述言語
英語
掲載種別
DOI
10.1046/j.1365-2133.1998.02369.x
出版者・発行元
BLACKWELL SCIENCE LTD

We diagnosed a unique case of Merkel cell carcinoma (MCC) coexisting with Bowen's disease on the sole of the foot of a 72-year-old man who had worked for about 4 years in a factory handling inorganic arsenic. He had a past history of arsenical keratosis and multiple Bowen's disease. The tumour first appeared as a reddish macule and then showed marked growth over the next month. The tumour was excised and the specimen was examined histopathologically. The tumour consisted of two components: a group of atypical cells representing Bowen's disease in the epidermis and another group of atypical cells with a trabecular pattern characteristic of MCC in the dermis. Neither group of cells showed transitional findings, and the tumour elements were divided by a clear basement membrane. The tumour cells in the dermis were positive for neurone-specific enolase, and on electron microscopy had dense core granules in the cytoplasm. Inorganic arsenic can cause various cutaneous neoplasms, but to our knowledge, this is the first report of a case of MCC associated with Bowen's disease.

Web of Science ® 被引用回数 : 27

リンク情報
DOI
https://doi.org/10.1046/j.1365-2133.1998.02369.x
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000075593700020&DestApp=WOS_CPL

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