MISC

1999年6月

Mechanisms of noradrenaline-induced vasorelaxation in isolated femoral arteries of the neonatal rat

BRITISH JOURNAL OF PHARMACOLOGY
  • H Nishina
  • ,
  • T Ozaki
  • ,
  • MA Hanson
  • ,
  • L Poston

127
4
開始ページ
809
終了ページ
812
記述言語
英語
掲載種別
DOI
10.1038/sj.bjp.0702641
出版者・発行元
WILEY-BLACKWELL

Isolated arteries from the femoral circulation of Wistar rats mounted on a small vessel myograph demonstrated age related tension development to noradrenaline (NA, 1 x 10(-8) -5 x 10(-5) M) day 20 greater than day 10 (P < 0.005); day 100 greater than day 20 (P < 0.001) and depolarizing potassium (125 mM) buffer day 20 greater than day 10 (P < 0.001). NA evoked dilatation in femoral arteries from neonatal rats (10 days) when added to unstimulated vessels or to those preconstricted with the thromboxane mimetic, U46619. Relaxation to NA was inhibited by L-NAME (0.1 mM) (P < 0.001), endothelial removal (P < 0.001) and the alpha(2)-adrenoceptor antagonist, yohimbine (0.1 mu M) (P < 0.001). alpha(1)- or beta-adrenoceptor antagonism was without effect. Relaxation was evoked in femoral arteries of the 10-day-old rats by the alpha(2)-adrenoceptor agonist UK14304 (1 x 10(-8) -5 x 10(-5) M). This relaxation was also abolished by L-NAME (0.1 mM) (P < 0.001) or endothelial removal (P < 0.001). a,adrenoceptor-mediated vasorelaxation was the predominant response to NA stimulation in femoral arteries of the neonatal rat. These responses were endothelium-dependent and were NO-mediated.

Web of Science ® 被引用回数 : 19

リンク情報
DOI
https://doi.org/10.1038/sj.bjp.0702641
CiNii Articles
http://ci.nii.ac.jp/naid/80011154640
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/10433486
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000081077800001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1038/sj.bjp.0702641
  • ISSN : 0007-1188
  • CiNii Articles ID : 80011154640
  • PubMed ID : 10433486
  • Web of Science ID : WOS:000081077800001

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