2010年12月
Convergent synthesis of fluorescence-labeled probes of Annonaceous acetogenins and visualization of their cell distribution
BIOORGANIC & MEDICINAL CHEMISTRY
- 巻
- 18
- 号
- 24
- 開始ページ
- 8630
- 終了ページ
- 8641
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bmc.2010.10.004
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
The convergent synthesis of fluorescence-labeled solamin, an antitumor Annonaceous acetogenin, was accomplished by two asymmetric alkynylations of 2,5-diformyl tetrahydrofuran with an alkyne tagged with fluorescent groups and another alkyne with an alpha,beta-unsaturated gamma-lactone. Assay for the growth inhibitory activity against human cancer cell lines revealed that the probe with the fluorescent groups at the end of the hydrocarbon chain may have the same mode of action as natural acetogenins. The merged fluorescence of dansyl-labeled solamin and MitoTracker Red suggests that Annonaceous acetogenins localize in the mitochondria. (C) 2010 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.bmc.2010.10.004
- ISSN : 0968-0896
- eISSN : 1464-3391
- Web of Science ID : WOS:000284686000019