論文

査読有り
2010年12月

Convergent synthesis of fluorescence-labeled probes of Annonaceous acetogenins and visualization of their cell distribution

BIOORGANIC & MEDICINAL CHEMISTRY
  • Naoto Kojima
  • ,
  • Takekuni Morioka
  • ,
  • Daisuke Urabe
  • ,
  • Masahiro Yano
  • ,
  • Yuki Suga
  • ,
  • Naoyoshi Maezaki
  • ,
  • Ayako Ohashi-Kobayashi
  • ,
  • Yasuyuki Fujimoto
  • ,
  • Masatomo Maeda
  • ,
  • Takao Yamori
  • ,
  • Takehiko Yoshimitsu
  • ,
  • Tetsuaki Tanaka

18
24
開始ページ
8630
終了ページ
8641
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bmc.2010.10.004
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

The convergent synthesis of fluorescence-labeled solamin, an antitumor Annonaceous acetogenin, was accomplished by two asymmetric alkynylations of 2,5-diformyl tetrahydrofuran with an alkyne tagged with fluorescent groups and another alkyne with an alpha,beta-unsaturated gamma-lactone. Assay for the growth inhibitory activity against human cancer cell lines revealed that the probe with the fluorescent groups at the end of the hydrocarbon chain may have the same mode of action as natural acetogenins. The merged fluorescence of dansyl-labeled solamin and MitoTracker Red suggests that Annonaceous acetogenins localize in the mitochondria. (C) 2010 Elsevier Ltd. All rights reserved.

Web of Science ® 被引用回数 : 10

リンク情報
DOI
https://doi.org/10.1016/j.bmc.2010.10.004
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000284686000019&DestApp=WOS_CPL

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