Akio Kihara

Profile Information

Affiliation: Hokkaido University Faculty of Pharmaceutical Sciences Professor

Degree: Ph. D. in Chemstry; Kyoto University(Mar, 1998 Kyoto University)

ORCID ID: https://orcid.org/0000-0001-5889-0788
J-GLOBAL ID: 200901097463336581

External link: http://www.pharm.hokudai.ac.jp/seika/index.html

My research focuses on the metabolism and patho- and physiological functions of lipids, such as sphingolipids and very long chain fatty acids, especially on skin barrier formation and dry eye.

Research Interests

Research Areas

Research History

Apr, 2008 - Present

Hokkaido University Faculty of Pharmaceutical Sciences Professor
Apr, 2007 - Mar, 2008

Hokkaido University Faculty of Pharmaceutical Sciences Associate Professor
Jan, 2005 - Mar, 2007

Hokkaido University Faculty of Pharmaceutical Sciences Assistant Professor
Jan, 2001 - Dec, 2004

Hokkaido University Faculty of Pharmaceutical Sciences Research Associate
Apr, 1999 - Dec, 2000

National Institute for Basic Biology Postdoctoral Research Fellow, Japan Society for the Promotion of Science

Education

Apr, 1995 - Mar, 1998

Kyoto University Graduate School of Science, Doctor Course
Apr, 1993 - Mar, 1995

Kyoto University Graduate School of Science, Master Course
Apr, 1989 - Mar, 1993

Kyoto University Faculty of Science

Committee Memberships

Oct, 2019 - Present

Japanese Society for Ceramides Vice-president
Feb, 2015 - Present

日本薬学会代議員
2014 - Present

Japanese Society for Ceramides Advisor
Jan, 2012 - Present

J. Biochem. Associate Editor
2012 - Present

日本生化学会評議員

Awards

Oct, 2015

Japanese Society for Ceramide JSC Award

Akio Kihara
Mar, 2015

Hokkaido University Hokkaido University President's Award

Akio Kihara
2005

The Japanese Biochemical Society Young Investigator Award of the Japanese Biochemical Society (2005)

Akio Kihara

Papers

132

Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals.

Honoka Tanno, Takayuki Sassa, Megumi Sawai, Akio Kihara

Biochimica et biophysica acta. Molecular and cell biology of lipids 1866(1) 158842 - 158842 Jan, 2021 Peer-reviewed
Impaired production of the skin barrier lipid acylceramide by CYP4F22 ichthyosis mutations.

Tomohiro Nohara, Yusuke Ohno, Akio Kihara

Journal of dermatological science Oct 6, 2020 Peer-reviewed
FTY720 Protects Against Ischemia-Reperfusion Injury by Preventing the Redistribution of Tight Junction Proteins and Decreases Inflammation in the Subacute Phase in an Experimental Stroke Model.

Zifeng Wang, Kei Higashikawa, Hironobu Yasui, Yuji Kuge, Yusuke Ohno, Akio Kihara, Yenari A Midori, Kiyohiro Houkin, Masahito Kawabori

Translational stroke research 11(5) 1103 - 1116 Oct, 2020 Peer-reviewed
Catalytic residues, substrate specificity, and role in carbon starvation of the 2-hydroxy FA dioxygenase Mpo1 in yeast.

Keisuke Mori, Takashi Obara, Naoya Seki, Masatoshi Miyamoto, Tatsuro Naganuma, Takuya Kitamura, Akio Kihara

Journal of lipid research 61(7) 1104 - 1114 Jul, 2020 Peer-reviewed
Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS.

Momoko Kawana, Masatoshi Miyamoto, Yusuke Ohno, Akio Kihara

Journal of lipid research 61(6) 884 - 895 Jun, 2020 Peer-reviewed

Misc.

小胞体における新たな脂肪酸α酸化経路

木原章雄

酵素工学ニュース 82 22 - 25 Oct, 2019 Peer-reviewed Invited
スフィンゴ脂質クオリティによる生体防御

木原章雄

The Lipid 30 28 - 34 Oct, 2019 Invited
極長鎖脂質による表皮および涙液における透過性バリア形成

木原章雄

医学のあゆみ 269 983 - 988 Jun, 2019 Invited
The role of PNPLA1 in ω-O-acylceramide synthesis and skin barrier function.

Tetsuya Hirabayashi, Makoto Murakami, Akio Kihara

Biochimica et biophysica acta. Molecular and cell biology of lipids 1864(6) 869 - 879 Jun, 2019 Peer-reviewed Invited
パルミトイル化

木原章雄

生体の科学 69 490 - 491 Oct, 2018 Invited

Books and Other Publications

セラミド研究の新展開〜基礎から応用へ〜

木原章雄(Role: Contributor, スフィンゴ脂質恒常性維持のためのセラミド分解経路)

セラミド研究会編，食品化学新聞社 Jun, 2019
Bioactive lipid mediators: current reviews and protocols

KIHARA Akio(Role: Contributor, Sphingolipid metabolism via sphingosine 1-phosphate)

Springer Japan 2015
ここまできたセラミド研究最前線セラミド –基礎と応用–

大野祐介, 木原章雄(Role: Contributor, 極長鎖脂肪酸伸長とセラミド合成)

セラミド研究会編，食品化学新聞社 2011
バイオとナノの融合 II 新生命科学の応用

五十嵐靖之, 木原章雄(Role: Contributor, スフィンゴ脂質の生理活性と代謝調節)

北海道大学 COE 研究成果編集委員編，北海道大学出版会 2007
Sphingolipid Biology

Kihara A, Igarashi Y(Role: Contributor, Synthesis, metabolism, and trans-bilayer movement of long-chain base.)

Springer-Verlag 2006

Presentations

Ceramide diversity and skin permeability barrier function

Akio Kihara

Nov 27, 2020 Invited
哺乳類セラミドの多様性を生み出す分子機構

木原章雄

第14回スフィンゴテラピィ研究会 Jan 25, 2020
Molecular mechanism producing the skin barrier lipid acylceramide

Kihara, A

60th International Conference on the Bioscience of Lipids Jun 21, 2019
Acylceramide production and skin barrier formation by the fatty acid omega-hydroxylase CYP4F22/Cyp4f39

Itoh N, Ohno Y, Sassa T, Kihara A

FEBS Special Meeting on Sphingolipid Biology (13th Sphingolipid Club & 10th International Ceramide Conference) May 8, 2019
極長鎖脂肪酸含有脂質による体表面バリア形成

木原章雄

第6回JFAS (Japan/Joy of Fatty Acids Secrets/Society) Mar 24, 2019 Invited

Teaching Experience

Professional Memberships

Research Projects

セラミド多様性を創出・維持する代謝経路とその破綻に起因する病態の分子機構の解明

文部科学省科学研究費補助金(基盤研究(A))

木原章雄
脂質による体表面バリア形成の分子機構の解明

国立研究開発法人日本医療研究開発機構 AMED-CREST

木原章雄
極長鎖脂質による生体機能調節とその破綻による病態の分子機構の解明

文部科学省科学研究費補助金(新学術領域研究)

木原章雄
極長鎖脂肪酸の産生及び代謝機構と代謝異常による病態の解明

文部科学省科学研究費補助金(基盤研究(A))

木原章雄
スフィンゴシン1-リン酸代謝経路に関わる遺伝子の同定と関連疾患の解析

文部科学省科学研究費補助金(新学術領域研究(研究領域提案型))

木原章雄

Industrial Property Rights

Academic Activities

第61回日本脂質生化学会，実行委員長

Planning, management, etc.

木原章雄 Jul 4, 2019 - Jul 5, 2019
2nd Japan-Korea Lipid Joint Symposium, Organizer

Planning, management, etc.

Akio Kihara Sep 12, 2018 - Sep 14, 2018
第143回日本薬学会北海道支部，例会長

Planning, management, etc.

日本薬学会 May 14, 2016 - May 15, 2016
FASEB Summer Research conferences, Co-organizer

Planning, management, etc.

Yasuyuki Igarashi Aug 4, 2013 - Aug 9, 2013

Social Activities

UHB大学

Lecturer

北海道文化放送 Nov 17, 2020 - Nov 17, 2020
道新アカデミー

Lecturer

北海道新聞 Sep 26, 2019 - Sep 26, 2019
第10回北大セミナーin旭川

Lecturer

北海道大学 Jul 20, 2019 - Jul 20, 2019

Media Coverage

ドライアイ防ぐ涙の脂質特定

北海道新聞夕刊2面 Apr 22, 2020 Newspaper, magazine
涙中の特殊な脂質がドライアイを防ぐ北海道大が解明

Science Portal https://scienceportal.jst.go.jp/newsflash/20200417_01/ Apr 17, 2020 Internet
体守る皮膚の脂質合成に関わる遺伝子

日経新聞 9面 Jan 29, 2020 Newspaper, magazine
ドライアイ防止涙の脂質が重要

毎日新聞 Feb 1, 2018 Newspaper, magazine
Gene Involved in defective skin barrier and eczema and ichthyosis identified

MedicalResearch.com https://medicalresearch.com/author-interviews/gene-involved-in-defective-skin-barrier-and-eczema-and-ichthyosis-identified/33925/ Apr 17, 2017 Internet

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Awards

Papers

Misc.

Books and Other Publications

Presentations

Teaching Experience

Professional Memberships

Research Projects

Industrial Property Rights

Academic Activities

Social Activities

Media Coverage

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Coauthors