1992年9月
CONSTRUCTION OF A DICTIONARY OF SEQUENCE MOTIFS THAT CHARACTERIZE GROUPS OF RELATED PROTEINS
PROTEIN ENGINEERING
- ,
- ,
- ,
- 巻
- 5
- 号
- 6
- 開始ページ
- 479
- 終了ページ
- 488
- 記述言語
- 英語
- 掲載種別
- 出版者・発行元
- OXFORD UNIV PRESS UNITED KINGDOM
An automatic procedure is proposed to identify, from the protein sequence database, conserved amino acid patterns (or sequence motifs) that are exclusive to a group of functionally related proteins. This procedure is applied to the PIR database and a dictionary of sequence motifs that relate to specific superfamilies constructed. The motifs have a practical relevance in identifying the membership of specific super-families without the need to perform sequence database searches in 20% of newly determined sequences. The sequence motifs identified represent functionally important sites on protein molecules. When multiple blocks exist in a single motif they are often close together in the 3-D structure. Furthermore, occasionally these motif blocks were found to be split by introns when the correlation with exon structures was examined.
- リンク情報
- ID情報
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- ISSN : 0269-2139
- Web of Science ID : WOS:A1992JP72800002