Sayoko Koyama - My portal

Profile Information

Degree: ph.D (medical)(The University of Tokyo)

Other name(s) (e.g. nickname): Ogura
Researcher number: 30618202
J-GLOBAL ID: 201101029108882551
researchmap Member ID: 1000294746

Research Interests

Research Areas

Life sciences / Internal medicine - General / General Internal Medicine (includes Psychosomatic Medicine)
Other / Other / Pathological Examination Studies Laboratory medicine

Research History

Apr, 2011

University of Medicine,
Apr, 2009 - Mar, 2011

National Cardiovascular Center Vascular Phisiology
Assistant Professor, Nihon University School of Medicine, Department of Medicine, -

Education

Apr, 2003 - Mar, 2007

Internal Medicne, Graduate School, Division of Medicine, The University of Tokyo
Apr, 1993 - Mar, 1999

Department of Medicine, Faculty of Medicine, Tokyo Women's Medical University

Awards

Papers

Antihypertensive drug therapy for women with non-severe hypertensive disorders of pregnancy: a systematic review and meta-analysis.

Ogura S, Suzuki J, Suzuki H

Hypertens Res., Jan 9, 2019 Peer-reviewedInvited
Targeting LOX-1 in atherosclerosis and vasculopathy: current knowledge and future perspectives.

Tian K, Ogura S, Little PJ, Xu SW, Sawamura T

Ann N Y Acad Sci., Nov 1, 2018 Peer-reviewedInvited
Renal Denervation Improves Cardiac Diastolic Dysfunction by Restoring Serca2a Transcription in Uninephrectomized Rats

Hirohama D, Kawakami-Mori F, Ogura S, Mu S, Jimbo R, Uetake U, Yatomi, Y, Nangaku M, Fujita T, Shimosawa T

J. Hypertens, 5(2) 1000225, May 24, 2016 Peer-reviewed
Novel round cells in urine sediment and their clinical implications.

Shukuya K, Ogura S, Tokuhara Y, Okubo S, Yatomi Y, Tozuka M, Shimosawa T

Clinica Chimica Acta, 457 142-149, Apr 19, 2016 Peer-reviewed
Vascular Inflammation and Hypertension

Ogura S, Latapati R, Shimosawa T, Nakayama T

Austin Journal of Cardiovascular Disease and Atherosclerosis, 3(1), Apr 6, 2016 Peer-reviewedInvited
血中CRP複合体のプロテオーム解析

小倉彩世子, 中山智祥, 下澤達雄

日本大学医学部総合医学研究所紀要, 3 46-48, Dec 1, 2015 Invited
β2-Adrenergic receptor-dependent attenuation of hypoxic pulmonary vasoconstriction prevents progression of pulmonary arterial hypertension in intermittent hypoxic rats.

Nagai H, Kuwahira I, Schwenke DO, Tsuchimochi H, Nara A, Inagaki T, Ogura S, Fujii Y, Umetani K, Shimosawa T …

PLoS One., 9(10) e110693., Aug 16, 2014
Oxidative Stress and Organ Damages

Sayoko Ogura, Tatsuo Shimosawa

CURRENT HYPERTENSION REPORTS, 16(8) 452, Aug, 2014 Peer-reviewedInvited
LOX-1 in atherosclerosis: Biological functions and pharmacological modifiers

Suowen Xu, Sayoko Ogura, Jiawei Chen, Peter J. Little, Joel Moss, Peiqing Liu

Cellular and Molecular Life Sciences, 70(16) 2859-2872, Aug, 2013 Peer-reviewed
Oxidative stress augments pulmonary hypertension in chronically hypoxic mice overexpressing the oxidized LDL receptor.

Ogura S, Shimosawa T, Mu S, Sonobe T, Kawakami-Mori F, Wang H, Uetake Y, Yoshida K, Yatomi Y, Shirai M …

Am J Physiol Heart Circ Physiol., 305(2) H155-62, Jul 15, 2013 Peer-reviewed
Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart.

Maeda H, Nagai H, Takemura G, Shintani-Ishida K, Komatsu M, Ogura S, Aki T, Shirai M, Kuwahira I, Yoshida KI

Biochim Biophys Acta., 1832(8) 1159-66, Mar 14, 2013 Peer-reviewed
Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation.

Xu S, Liu Z, Huang Y, Le K, Tang F, Huang H, Ogura S, Little PJ, Shen X, Liu P

Traslational Research, 160(2) 114-124, Aug, 2012 Peer-reviewed
Oxidative Stress in Multiple Organ Damage in Hypertension, Diabetes and CKD, Mechanisms and New Therapeutic Possibilities

Tatsuo Shimosawa, Tomoyo Kaneko, Xu Qingyou, Yusei Miyamoto, Mu Shengyu, Hong Wang, Sayoko Ogura, Rika Jimbo, Bohumil Majtan, Yuzaburo Uetake …

Oxidative Stress and Diseases., Apr 25, 2012 Peer-reviewed
NADPH oxidase-mediated Rac1 GTP activity is necessary for non-genomic actions of the mineralocorticoid receptor in the CA1 region of the rat hippocampus.

Mori FK, Shimosawa T, Wang H, Ogura S, Mu S, Yatomi Y, Fujita T

Am J Physiol Endocrinol Metab., 15(302) E425-32, Nov 22, 2011 Peer-reviewed
Epigenetic modulation of the renal β-adrenergic-WNK4 pathway in salt-sensitive hypertension.

Mu S, Shimosawa T, Wang H, Uetake Y, Kawakami-Mori F, Marumo T, Yatomi Y, Geller DS, Tanaka H, Fujita T

Nature Medicine, 17(5) 573-580, May 1, 2011 Peer-reviewed
LOX Index, a Novel Predictive Biochemical Marker for Coronary Heart Disease and Stroke.

Inoue, N, T. Okamura, Y. Kokubo, Y. Fujita, Y. Sato, M. Nakanishi, K. Yanagida, A. Kakino, S. Iwamoto, M. Watanabe …

Clinical Chemistry, 56(4) 550-558, Apr 1, 2010 Peer-reviewed
Lox-1: the multifunctional receptor underlying cardiovascular dysfunction.

A. Kakino, Y. Sato, Y. Fujita, S. Iwamoto, K. Otsui, R. Yoshimoto, T. Sawamura

Circulation Journal, 73 1993-1999, Nov 13, 2009 Peer-reviewed
Paradoxical mineralocorticoid receptor activation and left ventricular diastolic dysfunction under high oxidative stress conditions. J

Wang H, Shimosawa T, Matsui H, Kaneko T, Uetake Y, Takenaka K, Yatomi Y, Fujita T

Journal of Hypertension, 26(7) 1453-62, Jul 1, 2008 Peer-reviewed
Protective effect of potassium against the hypertensive cardiac dysfunction: association with reactive oxygen species reduction.

Matsui H, Shimosawa T, Uetake Y, Wang H, Kaneko T, Liu J, Ando K, FujitaT

Hypertension, 48(2) 225-231, Aug 1, 2006 Peer-reviewed
Venous sampling for fibroblast growth factor-23 confirms preoperative diagnosis of tumor-induced osteomalacia.

Takeuchi Y, Suzuki H, Imai R, Yamazaki Y, Yamashita T, Miyamoto Y, Okazaki H, Nakamura K, Nakahara K, Fukumoto S …

Journal of Clinical Endocrinology & Metabolism., 89(8) 3979-3982, Aug 1, 2004 Peer-reviewed

Misc.

Pulmonary Arterial Hypertension in Rats Due to Age-Related Arginase Activation in Intermittent Hypoxia

Akina Nara, Hisashi Nagai, Kaori Shintani-Ishida, Sayoko Ogura, Tatsuo Shimosawa, Ichiro Kuwahira, Mikiyasu Shirai, Ken-ichi Yoshida

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 53(2) 184-192, Aug, 2015 Peer-reviewed
Pulmonary Macrophages Attenuate Hypoxic Pulmonary Vasoconstriction via beta(3)AR/iNOS Pathway in Rats Exposed to Chronic Intermittent Hypoxia

Hisashi Nagai, Ichiro Kuwahira, Daryl O. Schwenke, Hirotsugu Tsuchimochi, Akina Nara, Sayoko Ogura, Takashi Sonobe, Tadakatsu Inagaki, Yutaka Fujii, Rutsuko Yamaguchi …

PLOS ONE, 10(7) e0131923, Jul, 2015 Peer-reviewed
High-salt in addition to high-fat diet may enhance inflammation and fibrosis in liver steatosis induced by oxidative stress and dyslipidemia in mice

Yuzaburo Uetake, Hitoshi Ikeda, Rie Irie, Kazuaki Tejima, Hiromitsu Matsui, Sayoko Ogura, Hong Wang, ShengYu Mu, Daigoro Hirohama, Katsuyuki Ando …

Lipids in Health and Disease, 14(6), Feb 13, 2015

Books and Other Publications

妊娠高血圧治療のエビデンスと降圧治療についての課題

鈴木洋通, 小倉彩世子, 坂早苗, 鈴木純, 辰巳友佳子

先端医学社, Jun 1, 2018
臨床検査増刊号疾患・病態を理解する—尿沈渣レファレンスブック

宿谷賢一, 小山彩世子, 下澤達雄 (Role: Joint author, 尿沈渣成分と各種要因の関連性)

医学書院, Apr 10, 2018
これだけは知っておきたい検査のポイント第９集

小倉彩世子, 下澤達雄 (Role: Joint author, 銅)

医学書院, Apr 1, 2015
内分泌学からみた血圧調節のメカニズムインスリン

下澤達雄 (Role: Joint author, 432-436)

科学評論社, Nov 28, 2012
臨床高血圧ワークブック～エビデンスを超えた次の一手～第１巻血圧の評価と高血圧の診断

下澤達雄 (Role: Joint author, 27-33)

医薬ジャーナル社, Aug 10, 2012
最新メタボリックシンドローム診療マニュアル

下澤達雄 (Role: Joint author, 43-45)

医歯薬出版, Dec 1, 2009
高血圧治療薬ハンドブック

下澤達雄 (Role: Joint author, 149-151)

羊土社, Mar 1, 2009
Up to Date 循環器系第3版

藤田敏郎 (Role: Joint author, 256-257)

先端医学社, Aug 1, 2004

Presentations

LC/MS解析による血中CRP複合体についての検討

小倉彩世子, 下澤達雄, 中山智祥

第48回日本心脈管作動物質学会, Feb 8, 2019
Low dose N-nitro-L-arginine Methyl Ester (L-NAME) causes salt sensitive hypertension via activation of NA + -Cl − cotransporter (NCC)

Wang Conghui, Shimosawa Tastuo, Koid Suang Suang, Ogura Sayoko Reheman Latapati

The 27th Scientific Meeting of International Society of Hypertension, Sep 20, 2018
間欠的低酸素によるNCC 活性化メカニズムと炎症の関連性

小倉彩世子, Yeerbolati Alimila, Rehaman Latapati, Wang Conghui, Liu BeiBei, Koid Suang Suang, Shand Francis, 下澤達雄

第41回日本高血圧学会総会, Sep 14, 2018
Oxidative stress Causes Salt sensitive Hypertension Via activation of Na+-Cl- Cotranporter (ncc)

Conghui Wang, Tatsuo Shimosawa, Reheman Latapati, Suangsuang Koid, Alimila Yeerbolati, Beibei Liu, Sayoko Ogura, Fumiko Mori, Toshiro Fujita

Joint Hypertension 2018 Scientific Sessions, Sep 6, 2018, AHA Council on Hypertension AHA Council on Kidney in Cardiovascular Disease American Society of Hypertension
The mechanism of Salt-sensitive Hypertension in Intermittent Hypoxia

Alimila Yeerbolati, Sayoko Ogura, Tatsuo Shimosawa, Hideyuki Maeda

Joint Hypertension 2018 Scientific Sessions, Sep 6, 2018, AHA Council on Hypertension | AHA Council on Kidney in Cardiovascular DiseaseAmerican Society of Hypertension
The mechanism of Salt-sensitive Hypertension in Intermittent Hypoxia

Alimila Yeerbolati, Sayoko Ogura, Latapati Reheman, Tatsuo Shimosawa

第61回日本腎臓病学会, Jun 8, 2018
High salt diet increases Prostaglandin E2 Synthesis thorugh oxidative stress.

Rehaman Latapati, 森典子, 広浜大五郎, 小倉彩世子, 王聡彗, Alimila Yeerbolati, Liu Beibei, 藤田敏郎, 矢富裕, 下澤達雄

第22回日本心血管内分泌代謝学会学術総会, Apr 29, 2018
Oxidative stress responsible for saltinducedPGE2 expression

Latapati Reheman, Fumio Kawakami Mori, Yukihisa Murata, Tatsuro Nakamura, Sayoko Ogura, Yutaka Yatomi, Tatsuo Shimosawa

第34回国際心臓研究学会日本部会, Dec 10, 2017
LC/MS解析による血中CRP複合体についての検討

小倉彩世子, 下澤達雄, 中山智祥

第21回日本心血管内分泌代謝学会学術総会, Dec 9, 2017
Low dose L-NAME causes salt sensitivehypertension via activation of NCC

Wang Conghui, Sayoko Ogura, Fumiko Mori, Suang Koid, Yeerbolati Alimila, Latapai Reheman, Beibei Li, Tatsuo Shimosawa

第34回国際心臓研究学会日本部会, Dec 8, 2017
当院における不規則抗体スクリーニングで検出された酵素法陽性LISS-IAT陰性例の頻度と検証

志方えりさ, 佐々木貴代子, 平塚ひとみ, 田島八重子, 荒木秀夫, 高橋宏通, 小倉彩世子, 星野忠, 藤岡和美里村厚司, 中山智祥

第64回日本臨床検査医学会学術集会, Nov 16, 2017
Low Dose N-nitro-L-arginide MethylEser(L-NAME) causes Salt sensitive Hypertension via Activation of Na+ Cl- Cotransporter (NCC)

Conghui Wang, Reheman Latapati, Sayoko Ogura, Suangsung Koid, Fumiko Mori, Tatsuo Shimosawa

第40回日本高血圧学会総会, Oct 21, 2017
THE mechanism of salt sensitive hypertension in intermittent hypoxia

Alimila Yeerbolati, Sayoko Ogura, Latapati Reheman, Tatsuo Shimosawa

第40回日本高血圧学会総会, Oct 20, 2017
Low Dose LNAME Causes Salt Sensitive Hypertension via Activation of NCC.

Conghui Wang, Reheman Latapati, Sayoko Ogura, Suangsuang Koid, Fumiko Mori, Tastuo Shimosawa

AHA Council on HypertensionAHA Council on Kidney in Cardiovascular DiseaseAmerican Society of HypertensionJoint Scientific Sessions 2017, Sep 17, 2017
THE MECHANISM OF SALT SENSITIVE HYPERTENSION IN INTERMITTENT HYPOXIA

Alimila Yeerbolati, Sayoko Ogura, Latapati Reheman, Conghui Wang, BeiBei Liu, Ichiro Kuwahira, Mikiyasu Shirai, Tatsuo Shimosawa, Toshiro Fujita

International Society of Hypertension 2016, Sep 28, 2016
睡眠時無呼吸症候群における食塩感受性高血圧のメカニズム解明

小倉彩世子, Wang Conghui, Liu BeiBei, Yeerbolati Alimila, Rehaman Latapati, 下澤達雄, 藤田敏郎

第19回日本心血管内分泌代謝学会学術総会, Dec 11, 2015
睡眠時無呼吸症候群における食塩感受性高血圧のメカニズム解明

小倉彩世子, Wang Conghui, Liu BeiBei, Yeerbolati Alimila, Rehaman Latapati, 広浜大五郎, 丸茂丈史, 藤田敏郎

第38回日本高血圧学会総会, Oct 10, 2015
LC/MS解析による血中CRP複合体についての検討

小倉彩世子, 里村厚司, 星野忠, 荒島康友, 志方えりさ, 藤岡和美, 下澤達雄, 中山智祥

第47回日本臨床検査自動化学会, Oct 9, 2015
LC/MS解析による血中CRP複合体についての検討

小倉彩世子, 里村厚司, 星野忠, 荒島康友, 志方えりさ, 藤岡和美, 下澤達雄, 中山智祥

第40回医用マススペクトル学会, Sep 17, 2015
Different patterns of coronary microvascular function induced by type 1 diabetes and intermittent hypoxia in rats

Ogura, S, Shimosawa, T, Nagai H, Nara A, Kuwahira I, Yoshida K, Shirai M

Frontiers in CardioVascular Biology, Jul 16, 2014

Professional Memberships

Research Projects

睡眠時無呼吸症候群における腎交感神経と高血圧のメカニズム解明

Grant-in-Aid for Scientific Research (C), 2014 - 2017
血清CRP複合体のプロテオーム解析

2014 - 2015

Other

血中CRP複合体のプロテオーム解析

Jun, 2018 - Jun, 2018

血中CRP複合体のプロテオーム解析