論文

査読有り
2019年1月

Combined effects of lactotripeptide and aerobic exercise on cognitive function and cerebral oxygenation in middle-aged and older adults

The American journal of clinical nutrition
  • Hamasaki, Ai
  • ,
  • Akazawa, Nobuhiko
  • ,
  • Yoshikawa, Toru
  • ,
  • Myoenzono, Kanae
  • ,
  • Tanahashi, Koichiro
  • ,
  • Sawano, Yuriko
  • ,
  • Nakata, Yoshio
  • ,
  • Maeda, Seiji

109
2
開始ページ
353
終了ページ
360
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/ajcn/nqy235
出版者・発行元
OXFORD UNIV PRESS

[Background] Age-related declines in cognitive function and cerebral perfusion increase the risk of dementia. Although nutrition and exercise may be effective in reducing cognitive decline, the effect of lactotripeptide (LTP) on cerebral oxygenation and hemodynamics remains unclear.
[Objectives] The aim of this study was to investigate the effects of LTP ingestion on cerebral oxygenation, cognitive function, and vascular function in middle-aged and older adults with or without an exercise intervention.
[Methods] We recruited 2 separate groups of participants, one with and one without an exercise intervention. Each group was then randomly assigned into a placebo group and an LTP group. The participants ingested a placebo or LTP every day. The exercise group performed aerobic exercises 4-6 d/wk. Before and after the 8-wk intervention, we measured oxygenated hemoglobin (oxy-Hb) concentration (oxy-Hb change) in the prefrontal cortex during the Stroop task (primary outcome), Stroop interference time, and carotid artery β-stiffness (both secondary outcomes).
[Results] Sixty-four participants completed the study. Changes in oxy-Hb signal in the prefrontal cortex were greater in the LTP g

リンク情報
DOI
https://doi.org/10.1093/ajcn/nqy235

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