論文

査読有り
2018年1月1日

Effect of habitual exercise on urinary liver-type fatty acid-binding protein levels in middle-aged and older adults

Scandinavian Journal of Medicine and Science in Sports
  • K. Kosaki
  • ,
  • A. Kamijo-Ikemori
  • ,
  • T. Sugaya
  • ,
  • K. Tanahashi
  • ,
  • Y. Sawano
  • ,
  • N. Akazawa
  • ,
  • S. G. Ra
  • ,
  • K. Kimura
  • ,
  • Y. Shibagaki
  • ,
  • S. Maeda

28
1
開始ページ
152
終了ページ
160
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/sms.12867
出版者・発行元
Blackwell Munksgaard

The purpose of this study was to examine the effect of habitual exercise on urinary liver-type fatty acid-binding protein (L-FABP), which can reflect the degree of various stresses on renal proximal tubule related to the progression of renal disease, in middle-aged and older adults. Cross-sectional and interventional approaches were used to comprehensively achieve this purpose. In the cross-sectional study, we investigated the relationship between physical activity levels and urinary L-FABP levels in 130 middle-aged and older adults. In the interventional study, subjects (n=31) were divided into two groups: exercise (n=19) and control group (n=12), whereby we examined the effects of 12-week aerobic exercise training on urinary L-FABP levels. The cross-sectional study showed that the urinary L-FABP levels were significantly lower in the higher physical activity group than in the lower physical activity group (P&lt
.05). In the interventional study, 12-week aerobic exercise training significantly decreased urinary L-FABP levels (P&lt
.01). Furthermore, the relative changes in urinary L-FABP levels were significantly correlated with the relative changes in physical activity levels and mean arterial pressure after intervention (r=−.374 and r=.530, respectively). Our results revealed that the urinary L-FABP levels were lower in the higher physical activity individuals, and aerobic exercise training decreased urinary L-FABP levels. These results suggest that habitual exercise appears to be associated with a decrease in the degree of several stresses on renal proximal tubule and to be beneficial for kidney health in middle-aged and older adults.

リンク情報
DOI
https://doi.org/10.1111/sms.12867

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