論文

査読有り
2017年12月

Effects of dietary modification with weight loss on central blood pressure during oral glucose tolerance test in overweight/obese men

ARTERY RESEARCH
  • Toru Yoshikawa
  • ,
  • Hiroshi Kumagai
  • ,
  • Kanae Myoenzono
  • ,
  • Asako Zempo-Miyaki
  • ,
  • Takehiko Tsujimoto
  • ,
  • Kiyoji Tanaka
  • ,
  • Seiji Maeda

20
開始ページ
27
終了ページ
34
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.artres.2017.10.199
出版者・発行元
ELSEVIER SCIENCE BV

Background: Postprandial regulation of central systolic blood pressure (cSBP) is impaired by obesity-related disorders. The present study aimed to examine the effect of hypocaloric diet intervention on cSBP when performing oral glucose tolerance test (OGTT) in overweight/obese men and explore its mechanism.
Methods: Fifteen overweight/obese men (mean +/- SD; age, 52 +/- 10 years; BMI, 29.1 +/- 2.3 kg/m(2)) completed a 12-week dietary modification program (group lectures and individual counseling conducted 8 times in 12 weeks, 1680 kcal/day). Before and after the program, body mass, daily intakes of total energy and major macronutrients, serum lipid profiles, and homeo-stasis model assessment for insulin resistance (HOMA-IR) were measured, and plasma glucose, serum insulin, and cSBP (i.e., radial second systolic pressure) were assessed when fasting and at 60 min and 120 min after 75 g oral glucose loading.
Results: The 12-week program led to successful weight loss (-10.1 kg or -12.1%) with significant reductions in the daily intakes of total energy and major macronutrients. Consequently, low-density lipoprotein cholesterol, triglycerides, HOMA-IR (2.1 +/- 1.3 to 0.8 +/- 0.3, p < 0.01), and glucose and insulin during OGTT were substantially decreased after 12 weeks. The diet program had also resulted in significantly reduced 2-h averaged cSBP during OGTT ( 111 +/- 11 to 103 +/- 10 mmHg, p < 0.01). There was a significant correlation between the changes from baseline in both HOMA-IR and 2-h averaged cSBP (r(s) = 0.69, p < 0.01).
Conclusions: The current results suggest that the dietary modification-induced improvement in insulin resistance has contributed to a significant reduction in cSBP during OGTT in over-weight/obese men. (C) 2017 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.


リンク情報
DOI
https://doi.org/10.1016/j.artres.2017.10.199
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000418230200006&DestApp=WOS_CPL

エクスポート
BibTeX RIS