論文

査読有り
2017年10月

Relationship between exercise capacity and urinary liver-type fatty acid-binding protein in middle-aged and older individuals

CLINICAL AND EXPERIMENTAL NEPHROLOGY
  • Keisei Kosaki
  • ,
  • Atsuko Kamijo-Ikemori
  • ,
  • Takeshi Sugaya
  • ,
  • Koichiro Tanahashi
  • ,
  • Hiroshi Kumagai
  • ,
  • Yuriko Sawano
  • ,
  • Nobuhiko Akazawa
  • ,
  • Song-Gyu Ra
  • ,
  • Kenjiro Kimura
  • ,
  • Yugo Shibagaki
  • ,
  • Seiji Maeda

21
5
開始ページ
810
終了ページ
817
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s10157-017-1385-x
出版者・発行元
SPRINGER

The underlying mechanism linking the decline in exercise capacity with renal dysfunction remains unclear. Urinary liver-type fatty acid-binding protein (L-FABP) levels reflect the degree of peritubular capillary blood flow, an important factor for renal dysfunction with aging. The aim of this study was to examine the relationship between exercise capacity and urinary L-FABP levels.
This was a cross-sectional study of 187 middle-aged and older individuals (aged 50-83 years) without chronic kidney disease (CKD). We assessed urinary L-FABP levels, peak oxygen consumption (), and grip strength.
Urinary L-FABP levels inversely correlated with both (r (s) = -0.349) and grip strength (r (s) = -0.485). When the participants were divided into four groups according to the median values of aerobic fitness and muscular strength ( and grip strength), urinary L-FABP levels were the highest in participants with lower levels of aerobic fitness and muscular strength (2.95 +/- 1.43 mu g/g creatinine) and the lowest in the participants with higher levels of aerobic fitness and muscular strength (1.33 +/- 0.76 mu g/g creatinine). The difference between the two groups was significant (P < 0.001).
Our results demonstrate that both and grip strength were inversely associated with urinary L-FABP levels in middle-aged and older individuals without CKD. This suggests that a decline in exercise capacity is associated with a reduction in peritubular capillary blood flow, providing a novel insight into the underlying mechanism linking the decline in exercise capacity to the development of renal dysfunction.

Web of Science ® 被引用回数 : 5

リンク情報
DOI
https://doi.org/10.1007/s10157-017-1385-x
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000413313900010&DestApp=WOS_CPL

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