YOSHIMURA Yuichi

J-GLOBAL         Last updated: Sep 27, 2018 at 13:32
 
Avatar
Name
YOSHIMURA Yuichi
Affiliation
Tohoku Medical and Pharmaceutical University
Section
Faculty of Pharmaceutical Sciences
Job title
Associate Professor
Degree
Ph.D.

Research Interests

 
 

Research Areas

 
 

Education

 
 
 - 
1991
Graduate School, Division of Pharmaceutical Sciences, Hokkaido University
 
 
 - 
1985
Faculty of Pharmaceutical Science, Hokkaido University
 

Published Papers

 
Wakamatsu Hideaki, Sasaki Yoshimi, Kawahata Masatoshi, Yamaguchi Kentaro, Yoshimura Yuichi
SYNTHESIS-STUTTGART   50(17) 3467-3486   Sep 2018   [Refereed]
Yoshimura Y, Wakamatsu H, Natori Y, Saito Y, Minakawa N
Beilstein journal of organic chemistry   14 1595-1618   Jun 2018   [Refereed]
Yoshimura Y, Saito Y, Natori Y, Wakamatsu H
Chemical & pharmaceutical bulletin   66(2) 139-146   Feb 2018   [Refereed]
Wakamatsu H, Nitta K, Shoji N, Natori Y, Saito Y, Yoshimura Y
Current protocols in nucleic acid chemistry   71 1.43.1-1.43.12   Dec 2017   [Refereed]
Wakamatsu Hideaki, Yanagisawa Rika, Kimura Sho, Osawa Nao, Natori Yoshihiro, Yoshimura Yuichi
SYNLETT   28(16) 2135-2138   Oct 2017   [Refereed]
Yoshimura Yuichi
HETEROCYCLES   94(9) 1625-1651   Sep 2017   [Refereed]
Kato A, Nakagome I, Sato K, Yamamoto A, Adachi I, Nash RJ, Fleet GW, Natori Y, Watanabe Y, Imahori T, Yoshimura Y, Takahata H, Hirono S
Organic & biomolecular chemistry   14(3) 1039-1048   Jan 2016   [Refereed]
Yoshimura Y, Kobayashi S, Kaneko H, Suzuki T, Imamichi T
Molecules (Basel, Switzerland)   20(3) 4623-4634   Mar 2015   [Refereed]
Natori Y, Sakuma T, Yoshimura Y, Kinami K, Hirokami Y, Sato K, Adachi I, Kato A, Takahata H
Bioorganic & medicinal chemistry letters   24(15) 3298-3301   Aug 2014   [Refereed]
Kan-no Hiroya, Saito Yukako, Omoto Shun, Minato Sakie, Wakamatsu Hideaki, Natori Yoshihiro, Imamichi Tomozumi, Takahata Hiroki, Yoshimura Yuichi
SYNTHESIS-STUTTGART   46(7) 879-886   Apr 2014   [Refereed]
Natori Y, Kikuchi S, Kondo T, Saito Y, Yoshimura Y, Takahata H
Organic & biomolecular chemistry   12(12) 1983-1994   Mar 2014   [Refereed]
Kiran Y. B., Wakamatsu Hideaki, Natori Yoshihiro, Takahata Hiroki, Yoshimura Yuichi
TETRAHEDRON LETTERS   54(30) 3949-3952   Jul 2013   [Refereed]
Saito Y, Yoshimura Y, Wakamatsu H, Takahata H
Molecules (Basel, Switzerland)   18(1) 1162-1173   Jan 2013   [Refereed]
Natori Yoshihiro, Kikuchi Shunsuke, Yoshimura Yuichi, Kato Atsushi, Adachi Isao, Takahata Hiroki
HETEROCYCLES   86(2) 1401-1417   Dec 2012   [Refereed]
Kato A, Hayashi E, Miyauchi S, Adachi I, Imahori T, Natori Y, Yoshimura Y, Nash RJ, Shimaoka H, Nakagome I, Koseki J, Hirono S, Takahata H
Journal of medicinal chemistry   55(23) 10347-10362   Dec 2012   [Refereed]
Yoshimura Y, Takahata H
Molecules (Basel, Switzerland)   17(10) 11630-11654   Sep 2012   [Refereed]
Yoshimura Yuichi, Kan-no Hiroya, Kiran Y. B., Natori Yoshihiro, Saito Yukako, Takahata Hiroki
SYNTHESIS-STUTTGART   44(8) 1163-1170   Apr 2012   [Refereed]
Taguchi Tatsuya, Imahori Tatsushi, Yoshimura Yuichi, Kato Atsushi, Adachi Isao, Kawahata Masatoshi, Yamaguchi Kentaro, Takahata Hiroki
HETEROCYCLES   84(2) 929-944   Jan 2012   [Refereed]
Haraguchi K, Horii C, Yoshimura Y, Ariga F, Tadokoro A, Tanaka H
The Journal of organic chemistry   76(21) 8658-8669   Nov 2011   [Refereed]
Yoshimura Y, Yamazaki Y, Saito Y, Natori Y, Imamichi T, Takahata H
Bioorganic & medicinal chemistry letters   21(11) 3313-3316   Jun 2011   [Refereed]

Misc

 
吉村祐一
東北薬科大学研究誌   (61) 1-10   Dec 2014
吉村祐一, 高畑廣紀
有機合成化学協会誌   67(8) 798-808   Aug 2009
三浦信仕, 伊豆田俊二, 吉村祐一, 田中基裕, 佐々木琢磨
Jpn J Cancer Res   91(Supplement (Sept)) 578-579   Sep 2000
吉村祐一
化学と工業   49(11) 1582   Nov 1996
Synthesis of 2'-Deoxy-6,3'-Methano-Cyclo-Pyrimidine Nucleosides(共著)
Nucleic Acids Symposium Series   17 53-55   1986
YUICHI YOSHIMURA, TOMOHARU SANO, AKIRA MATSUDA, TOHRU UEDA
Chem. Pharm. Bull.   36(1) 162-167   1988
Synthesis of 6,3'-Methanothymidine from a Ribofuranos-3-ulose and 2,4-Dimethoxy-5,6-dimethylpyrimidine (共著)
Nucleosides Nucleotides   7 409-416   1988
Synthesis and Biological Activity of Branched Chain-sugar Nucleosides(共著)
Nucleosides Nucleotides   8 743-752   1989
Syntheis of 2'-Deoxy-6,2'-methano-pyrimidine Nucleosides and Optical Properties of Pyrimidine C-Cyclonucleosides(共著)
Nucleic Acids Symposium Series   21 79-80   1989
Yuichi YOSHIMURA, Akira MATSUDA, Tohru UEDA
Chem. Pharm. Bull.   38(2) 389-392   1990
Diels-Alder Reaction of Nucleosides ; Synthesis of Bicyclic Suger Adenosine Derivatives (共著)
Nucleic Acids Symposium Series   22 5-6   1990
Synthesis and Conformational Studies of O5', 6-Methanouridine-a New Type of Pyrimidine Cyclonucleoside (共著)
Nucleosides Nucleotides   11 615-635   1992
Yuichi YOSHIMURA, Brian A. OTTER, Tohru UEDA, Akira MATSUDA
Chem. Pharm. Bull.   40(7) 1761-1769   1992
Tetrahedron   49(38) 8513-8528   1993
Nucleosides Nucleotides. 120. Stereoselective Radical Deoxygenation of tert-Alcohols in the Sugar Moiety of Nucleosides : Synthesis of 2', 3'-Dideoxy-2'-C-methyl-and 2'-C-ethynyl-β-D-threo-pentofuranosyl Pyrimidines and Adenine as Potential Antivi...
Synthesis and Biological Activity of 1-(2-Deoxy-2-C-fluoromethyl-and 2-C-hydroxymethylarabinofuranosyl)cytosines(共著)
Nucleic Acids Symposium Series   29 33-34   1993
Higly Stereoselective Synthesis of Bicyclic-Sugar Adenosine Derivatives via Diels-Alder Reaction(共著)
Nucleic Acids Symposium Series   29 39-40   1993
Synthesis of (2'S)-1-(2-C-Azidomethyl-2-deoxy and 2-C-cyanomethyl-2-deoxy-β-D-arabinofuranosyl)cytosines(共著)
Nucleosides Nucleotides   14 427-429   1995
Synthesis and Biological Evaluation of 1'-C-Cyano-pyrimidine Nucleosides(共著)
Nucleosides Nucleotides   15 305-324   1996
A Novel Synthesis of Antineoplastic 4'-Thionucleosides using D-Glucose as a Chiral Synthon(共著)
Nucleic Acids Symposium Series   34 161-162   1995
A Facile Synthesis of 4'-Thio-arabinonucleosides as Potential Antiviral Agents from D-Glucose(共著)
Nucleic Acids Symposium Series   34 21-22   1995
Shinji MIURA, Motohiro TANAKA, Yuichi YOSHIMURA, Hiroshi SATOH, Shinji SAKATA, Haruhiko MACHIDA, Akira MATSUDA, Takuma SASAKI
Biol. Pharm. Bull.   19(10) 1311-1315   1996
Synthesis of 2'-Deoxy-2'-fluoro-4'-thioarabinonuclesides as Potential Antitumor and Antiviral Agents from D-Glucose(共著)
Nucleic Acids Symposium Series   35 15-16   1996
Synthesis of Iso-4'-thionucleosides Using the Mitsunobu Reaction(共著)
Nucleic Acids Symposium Series   35 55-56   1996
Synthesis and Biological Activities of 2'-Modified 4'-thionucleosides(共著)
Nucleosides Nucleotides   16 1103-1106   1997
Synthesis and Antiviral Activities of 5-Substituted-1-(2-deoxy-2-C-methylene-4-thio-β-D-erythro-pentofuranosyl)uracils(共著)
Nucleosides Nucleotides   17 65-79   1998
Synthesis of 2'-Deoxy-2'-fluoro-4'-thioarabinonucleosides using the Pummerer Rearrangement and Their Biological Evaluaion(共著)
Nucleic Acids Symposium Series   37 43-44   1997
Bioorg. Med. Chem. Lett.   8 989-992   1998
An Alternative Synthesis of Antineoplastic Nucleoside 4'-ThioFAC(共著)
Nucleic Acids Symposium Series   39 11-12   1998
Synthesis of 4'-Thiocytarazid(共著)
Nucleic Acids Symposium Series   39 19-20   1998
Synthetic Studies on 2'-Substituted-4'-thiocytidine Derivatives as Antineoplastic Agents(共著)
Nucleosides Nucleotides   18 815-820   1999
A Novel and Promising Candidate at Anti-HIV Drug : PMPA
Kagaku to Kogyo(Chemistry and Chemical Industry)   49 1582   1996
The Antitumor Mechanism of 1-(2-Deoxy-2-fluoro-4-thio--D-arabinofuranosyl)cytosine; the Effects of Its Triphosphates on Mammalian DNA Polymerases (共著)
Jpn. J. Cancer Res.   92 562-567   2001
Rationale of 5-125I-Iodo-4’-Thio-2’-Deoxyuridine as a Potential Iodinated Proliferation Marker (共著)
J. Nucl. Med.   43 1218-1226   2002
Potent Antitumor Effect of 1-(2-Deoxy-2-fluoro-4-thio--D-arabinofuranosyl)cytosine on Peritoneal Dissemination Models of Gastrointestinal Cancers (共著)
Oncol. Report   9 1319-1322   2002
Shinji Miura, Kohei Yamada, Fumitaka Kano, Yuichi Yoshimura
Biol. Pharm. Bull.   27(4) 520-523   2004
Tetrahedron Lett.   47(4) 591-594   2006
Yoshimura, Y.; Yamazaki, Y.; Wachi, K.; Satoh, S.; Takahata, H.
Synlett   111-114   2007
Yoshimura, Y.; Asami, K.; Matsui, M.; Tanaka, H.; Takahata, H.
Org. Lett.   8(26) 6015-6018   2006
Asymmetric Synthesis of All Stereoisomers of Isofagomine using [2,3]-Wittig Rearrangement
Mihara, Y.; Ojima, H.; Imahori, T.; Yoshimura, Y.; Ouchi, H.; Takahata, H.
Heterocycles   72 633-645   2007
Yoshimura, Y.; Yamazaki, Y.; Kawahata, M.; Yamaguchi, K.; Takahata, H.
Tetrahedron Lett.   48(26) 4519-4522   2007
Yoshimura,Y.; Ohara, C.; Imahori, T.; Saito, Y.; Kato, A.; Miyauchi, S.; Adachi, I.; Takahata, H.
Bioorg. Med. Chem.   16 8273-8286   2008
Yoshimura, Y.; Ohta, M.; Imahori, T.; Imamichi, T.; Takahata, H.
Org. Lett.   10(16) 3449-3452   2008
Imahori, T.; Ojima, H.; Yoshimura, Y.; Takahata, H.
Chem. Eur. J.   14(34) 10762-10771   2008
Yoshimura,Y.; Ohara, C.; Miyagawa, T.; Takahata, H.
Heterocycles   77 635-644   2009
Yoshimura, Y.; Yamazaki, Y.; Saito, Y.; Takahata, H.
Tetrahedron   65(45) 9091-9102   2009
Yoshimura, Y.; Asami, K.; Imamichi, T.; Kuroda, T.; Shiraki, K.; Takahata, H.
J. Org. Chem.   75(12) 4161-4171   2010

Books etc

 
Design and New Types of Antitumor Nucleosides : The Synthesis and Antitumor Activity of 2'-Deoxy-(2'-C-substituted)cytidines (共著)
Nucleosides Nucleotides as Antitumor and Antiviral Agents (Plenum Publishing Co. )   

Conference Activities & Talks

 
中井啓陽, NOEL Sayar, 吉村祐一, 渡邉一弘
日本薬学会年会要旨集(CD-ROM)   2018   
渡邉一弘, 高橋央宜, 吉村祐一
日本薬学会年会要旨集(CD-ROM)   2018   
若松秀章, 池内麻衣, 吉村祐一
日本薬学会年会要旨集(CD-ROM)   2018   
渡邉一弘, 高橋央宜, 吉村祐一, 加藤正
複素環化学討論会講演要旨集   10 Oct 2017   
狩野裕考, 郷慎司, 新田昂大, VEILON Lucas, 藤居真優, 樺山一哉, 下山敦史, 深瀬浩一, 安藤弘宗, 石田秀治, 名取良浩, 吉村祐一, 鈴木明身, 井ノ口仁一
脂質生化学研究   1 Jun 2017   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2006 - 2008    Investigator(s): 吉村 祐一
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2009 - 2011    Investigator(s): Yuichi YOSHIMURA
To develop nucleoside derivatives applicable to nucleic acids medicine with high affinity and stability and to search new anti-HIV agents, we designed and synthesized novel nucleoside derivatives. The target compounds were nucleosides having 2, 6-...
Study on Medicinal and Organic Chemistry of Nucleoside Derivatives

Patents

 
Purine 4’-Thioarabinonucleosides
US Patent number: 5817639
1-(2-Deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine
US Patent number: 6147058
1-(2-Deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine
EP 0841344B1