論文

査読有り
2015年9月

Pathological features of proteinuric nephropathy resembling Alport syndrome in a young Pyrenean Mountain dog

JOURNAL OF VETERINARY MEDICAL SCIENCE
  • Go Sugahara
  • ,
  • Ichiro Naito
  • ,
  • Yuichi Miyagawa
  • ,
  • Takaaki Komiyama
  • ,
  • Naoyuki Takemura
  • ,
  • Ryosuke Kobayashi
  • ,
  • Takayuki Mineshige
  • ,
  • Junichi Kamiie
  • ,
  • Kinji Shirota

77
9
開始ページ
1175
終了ページ
1178
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1292/jvms.15-0117
出版者・発行元
JAPAN SOC VET SCI

The renal biopsy tissue from a 9-month-old, male Pyrenean Mountain dog with renal disorder and severe proteinuria was examined. Ultrastructural examination revealed multilaminar splitting and fragmentation of the glomerular basement membrane (GBM) and diffuse podocyte foot process effacement. Immunofluorescent staining for alpha(IV) chains revealed presence of alpha 5(IV) and complete absence of alpha 3(IV) and alpha 4(IV) chains in the GBM. Immunohistochemistry also revealed decreased and altered expression of nephrin and podocin in the glomeruli compared with normal canine glomeruli. These results suggested that the glomerular disease of the present case might be consistent with canine hereditary nephropathy resembling human Alport syndrome caused by genetic defect of type IV collagen, and indicated possible contribution of podocyte injury to severe proteinuria in this case.


リンク情報
DOI
https://doi.org/10.1292/jvms.15-0117
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25892536
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000362156900022&DestApp=WOS_CPL