論文

査読有り 国際誌
2019年7月

LOW-INTENSITY PULSED ULTRASOUND PREVENTS DEVELOPMENT OF BISPHOSPHONATE-RELATED OSTEONECROSIS OF THE JAW-LIKE PATHOPHYSIOLOGY IN A RAT MODEL

ULTRASOUND IN MEDICINE AND BIOLOGY
  • Kouki Hidaka
  • ,
  • Yuko Mikuni-Takagaki
  • ,
  • Satoko Wada-Takahashi
  • ,
  • Makiko Saita
  • ,
  • Ryota Kawamata
  • ,
  • Takenori Sato
  • ,
  • Akira Kawata
  • ,
  • Chihiro Miyamoto
  • ,
  • Yojiro Maehata
  • ,
  • Hirotaka Watabe
  • ,
  • Nobuyuki Tani-Ishii
  • ,
  • Nobushiro Hamada
  • ,
  • Shun-suke Takahashi
  • ,
  • Shinji Deguchi
  • ,
  • Ryohei Takeuchi

45
7
開始ページ
1721
終了ページ
1732
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.ultrasmedbio.2019.02.015
出版者・発行元
ELSEVIER SCIENCE INC

We developed a ratmodel of bisphosphonate-related osteonecrosis of the jaw (BRONJ) by removing amaxillary molar tooth (M1) from ovariectomized rats after treatment with alendronate. To mimic periodontitis, some of the rats were administered Porphyromonas gingivalis (p. gingivalis) at the M1 site every 2 to 3 d for 2 wk. Rats pretreated with alendronate plus p. gingivalis showed delayed healing of socket epithelia, periosteal reaction of alveolar bone formation and lower bone mineral density in the alveolus above adjacent M2 teeth. These abnormalities were prevented by tooth socket exposure to 20 min/d low-intensity pulsed ultrasound (LIPUS), which restored diminished expression of RANKL, Bcl-2, IL-6, Hsp70, NF-kappa B and TNF-alpha messenger ribonucleic acids in remote bone marrow, suggesting LIPUS prevented development of BRONJ-like pathophysiology in rat by inducing systemic responses for regeneration, in addition to accelerating local healing. Non-invasive treatment by LIPUS, as well as low-level laser therapy, may be useful for medication-related osteonecrosis of the jaw patients. (E-mail: takagaki@kdu.ac.jp) (C) 2019 World Federation for Ultrasound in Medicine & Biology. All rights reserved.

Web of Science ® 被引用回数 : 2

リンク情報
DOI
https://doi.org/10.1016/j.ultrasmedbio.2019.02.015
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31006496
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000470102300020&DestApp=WOS_CPL

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