2011年12月
Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway
Nature Structural and Molecular Biology
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- 巻
- 18
- 号
- 12
- 開始ページ
- 1432
- 終了ページ
- 1434
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/nsmb.2173
Metabolism is predicted to generate formaldehyde, a toxic, simple, reactive aldehyde that can damage DNA. Here we report a synthetic lethal interaction in avian cells between ADH5, encoding the main formaldehyde-detoxifying enzyme, and the Fanconi anemia (FA) DNA-repair pathway. These results define a fundamental role for the combined action of formaldehyde catabolism and DNA cross-link repair in vertebrate cell survival. © 2011 Nature America, Inc. All rights reserved.
- ID情報
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- DOI : 10.1038/nsmb.2173
- ISSN : 1545-9993
- ISSN : 1545-9985
- PubMed ID : 22081012
- SCOPUS ID : 82955235602