HIGASHIMOTO Ken

J-GLOBAL         Last updated: Dec 18, 2019 at 02:49
 
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Name
HIGASHIMOTO Ken
Affiliation
Saga University
Research funding number
30346887

Research Areas

 
 

Education

 
 
 - 
2001
Graduate School, Division of Medicine, Saga Medical School
 
 
 - 
1997
Faculty of Dentistry, Kyushu Dental College
 

Published Papers

 
Novel Mutations of CDKN1C in Japanese Patients with Beckwith-Wiedemann Syndrome.
Yatsuki H, Higashimoto K, Jozaki K, Koide K, Okada J, Watanabe Y, Okamoto N, Tsuno Y, Yoshida Y, Ueda K, Shimizu K, Ohashi H, Mukai T, Soejima H.
Genes Genom   35(2)    2013
Comprehensive analyses of imprinted differentially methylated regions reveal epigenetic and genetic characteristics in hepatoblastoma.
Rumbajan JM, Maeda T, Souzaki R, Mitsui K, Higashimoto K, Nakabayashi K, Yatsuki H, Nishioka K, Harada R, Aoki S, Kohashi K, Oda Y, Hata K, Saji T, Taguchi T, Tajiri T, Soejima H, Joh K.
BMC Cancer   13    2013
A novel de novo point mutation of the OCT-binding site in the IGF2/H19-imprinting control region in a Beckwith-Wiedemann syndrome patient.
Higashimoto K, Jozaki K, Kosho T, Matsubara K, Fuke T, Yamada D, Yatsuki H, Maeda T, Ohtsuka Y, Nishioka K, Joh K, Koseki H, Ogata T, Soejima H.
Clin Genet, published online: 4 Dec 2013      2013
A novel de novo point mutation of the OCT-binding site in the IGF2/H19-imprinting control region in a Beckwith-Wiedemann syndrome patient.
Higashimoto K, Jozaki K, Kosho T, Matsubara K, Fuke T, Yamada D, Yatsuki H, Maeda T, Ohtsuka Y, Nishioka K, Joh K, Koseki H, Ogata T, Soejima H.
86(6)    2014   [Refereed]
Novel Nonsense Mutation in the NLRP7 Gene Associated with Recurrent Hydatidiform Mole.
Ito Y, Maehara K, Kaneki E, Matsuoka K, Sugahara N, Miyata T, Kamura H, Yamaguchi Y, Kono A, Nakabayashi K, Migita O, Higashimoto K, Soejima H, Okamoto A, Nakamura H, Kimura T, Wake N, Taniguchi T, Hata K.
   2015   [Refereed]
Autosomal recessive cystinuria caused by genome-wide paternal uniparental isodisomy in a patient with Beckwith-Wiedemann syndrome.
Ohtsuka Y, Higashimoto K, Sasaki K, Jozaki K, Yoshinaga H, Okamoto N, Takama Y, Kubota A, Nakayama M, Yatsuki H, Nishioka K, Joh K, Mukai T, Yoshiura KI, Soejima H.
88(3)    2015   [Refereed]
Comprehensive and quantitative multilocus methylation analysis reveals the susceptibility of specific imprinted differentially methylated regions (DMRs) to aberrant methylation in Beckwith-Wiedemann syndrome with epimutations.
Maeda T, Higashimoto K, Jozaki K, Yatsuki H, Nakabayashi K, Makita Y, Tonoki H, Okamoto N, Takada F, Ohashi H, Migita M, Kosaki R, Matsubara K, Ogata T, Matsuo M, Hamasaki Y, Ohtsuka Y, Nishioka K, Joh K, Mukai T, Hata K, Soejima H.
16(12)    2014   [Refereed]
Fibroadenoma in a Beckwith-Wiedemann syndrome with paternal uniparental disomy of chromosome 11p15.5.
*Takama Y, Kubota A, Nakayama M, Higashimoto K, Jozaki K, Soejima H.
56(6)    2014   [Refereed]
Autosomal recessive cystinuria caused by genome-wide paternal uniparental isodisomy in a patient with Beckwith-Wiedemann syndrome.
Ohtsuka Y, Higashimoto K, Sasaki K, Jozaki K, Yoshinaga H, Okamoto N, Takama Y, Kubota A, Nakayama M, Yatsuki H, Nishioka K, Joh K, Mukai T, Yoshiura KI, Soejima H.
   2014   [Refereed]
Loss of CpG methylation is strongly correlated with loss of histone H3 lysine 9 methylation at DMR-LIT1 in patients with BeckwithWiedemann Syndrome.
Higashimoto K, Urano T, Sugiura K, Yatsuki H, Joh K, Zhao W, Iwakawa M, Ohashi H, Oshimura M, Niikawa N, Mukai T, Soejima H
Am. J. Hum. Genet.   73(4) 948-956   2003
Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT)gene expression in human cancer.
Nakagawachi T, Soejima H, Urano T, Zhao W, Higashimoto K, Satoh Y, Matsukura S, Kudo S, Kitajima Y, Harada H, Furukawa K, Matsuzaki H, Emi M, Nakabeppu Y, Miyazaki K, Sekiguchi M, Mukai T
Oncogene.   22(5) 8835-8844   2003
Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer
Soejima H,Nakagawachi T,Zhao W,Higashimoto K,Urano T,Matsukura S,Kitajima Y,Takeuchi M,Nakayama M,Oshimura M,Miyazaki K,Joh K,Mukai T
Oncogene   23(25) 4380-4388   2004
Beckwith-Wiedemann症候群の分子遺伝学
36(7) 278-281   Jul 2004
The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island.
Zhao W., Soejima H., Higashimoto K., Nakagawachi T., Urano T., Kudo S., Matsukura S., Matsuo S., Joh K., & Mukai T.
J. Biochem.   137(3) 431-440   2005
Comparative analyses of genomic imprinting and CpG island-methylation in mouse Murr1 and human MURR1 loci revealed a putative imprinting control region in mice.
Zhang Z., Joh K., Yatsuki H., Wang Y., Arai Y., Soejima H., Higashimoto K., Iwasaka T., Mukai T.
Gene   366(1) 77-86   2006
Japanese and North American/European patients with Beckwith-Wiedemann syndrome have different frequencies of some epigenetic and genetic alterations.
Sasaki K, Soejima H, Higashimoto K, Yatsuki H, Ohashi H, Yakabe S, Joh K, Niikawa N, Mukai T.
Eur. J. Hum. Genet.   15(12) 1205-1210   2007   [Refereed]
ゲノム刷り込みとBeckwith-Wiedemann症候群
22(3) 139-143   Jun 2008
MeCP2 knockdown reveals DNA methylation-independent gene repression of target genes in living cells and a bias in the cellular location of target gene products.
Yakabe S, Soejima H, Yatsuki H, Tominaga H, Zhao W, Higashimoto K, Joh K, Kudo S, Miyazaki K, Mukai T.
Genes Genet Syst   83(2) 199-208   Apr 2008   [Refereed]
Phosphorylation-mediated inactivation of coactivator-associated arginine methyltransferase 1.
Higashimoto K, Kuhn P, Desai D, Cheng X, Xu W.
Proc Natl Acad Sci U S A   104(30) 12318-12323   Jul 2007   [Refereed]
Expression profile of LIT1/KCNQ1OT1 and epigenetic status at the KvDMR1 in colorectal cancers.
Nakano S, Murakami K, Meguro M, Soejima H, Higashimoto K, Urano T, Kugoh H, Mukai T, Ikeguchi M, Oshimura M.
Cancer Sci.   97(11) 1147-1154   Nov 2006   [Refereed]
Genetic and epigenetic alterations on the short arm of chromosome 11 are involved in a majority of sporadic Wilms' tumours.
Satoh Y, Nakadate H, Nakagawachi T, Higashimoto K, Joh K, Masaki Z, Uozumi J, Kaneko Y, Mukai T, Soejima H.
Br J Cancer.   95(4) 541-547   Aug 2006   [Refereed]
Retinoic acid receptor beta2 is epigenetically silenced either by DNA methylation or repressive histone modifications at the promoter in cervical cancer cells.
Zhang Z, Joh K, Yatsuki H, Zhao W, Soejima H, Higashimoto K, Noguchi M, Yokoyama M, Iwasaka T, Mukai T.
Cancer Lett.   247(2) 318-327   Mar 2007   [Refereed]
Imprinting disruption of the CDKN1C/KCNQ1OT1 domain: the molecular mechanisms causing Beckwith-Wiedemann syndrome and cancer.
Higashimoto K, Soejima H, Saito T, Okumura K, Mukai T.
Cytogenet Genome Res.   113(1-4) 306-312   Oct 2006   [Refereed]
Primary palmar hyperhidrosis locus maps to 14q11.2-q13.
Higashimoto I, Yoshiura K, Hirakawa N, Higashimoto K, Soejima H, Totoki T, Mukai T, Niikawa N.
Am J Med Genet A.   140(6) 567-572   Mar 2006   [Refereed]
Antisense transcription occurs at the promoter of a mouse imprinted gene, commd1, on the repressed paternal allele.
Joh K, Yatsuki H, Higashimoto K, Mukai T, Soejima H.
J Biochem. 146 (6) 771-774.   146(6) 771-774   2009
Beckwith-Wiedemann syndrome with placental chorangioma due to H19-differentially methylated region hypermethylation: a case report.
Aoki A, Shiozaki A, Sameshima A, Higashimoto K, Soejima H, Saito S.
J Obstet Gynaecol Res.   37(12) 1872-1876   Dec 2011
CARM1 is an important determinant of ERα-dependent breast cancer cell differentiation and proliferation in breast cancer cells.
Al-Dhaheri M, Wu J, Skliris GP, Li J, Higashimoto K, Wang Y, White KP, Lambert P, Zhu Y, Murphy L, Xu W.
Cancer Res.   71(6) 2118-2128   Mar 2011
Aberrant methylation of H19-DMR acquired after implantation was dissimilar in soma versus placenta of patients with Beckwith-Wiedemann syndrome.
Higashimoto K, Nakabayashi K, Yatsuki H, Yoshinaga H, Jozaki K, Okada J, Watanabe Y, Aoki A, Shiozaki A, Saito S, Koide K, Mukai T, Hata K, Soejima H.
Am J Med Genet A.   158A(7) 1670-1675   2012
Congenital hyperinsulinism in an infant with paternal uniparental disomy on chromosome 11p15: Few clinical features suggestive of Beckwith-Wiedemann syndrome.
*Adachi H, Takahashi I, Higashimoto K, Tsuchida S, Noguchi A, Tamura H, Arai H, Ito T, Masue M, Nishibori H, Takahashi T, Soejima H.
Endocr J. [Advance Publication] Released: 2012/11/30      2012
Homozygous deletion of DIS3L2 exon 9 due to non-allelic homologous recombination between LINE-1s in a Japanese patient with Perlman syndrome.
Higashimoto K, Maeda T, Okada J, Ohtsuka Y, Sasaki K, Hirose A, Nomiyama M, Takayanagi T, Fukuzawa R, Yatsuki H, Koide K, Nishioka K, Joh K, Watanabe Y, Yoshiura KI, Soejima H.
Eur J Hum Genet.      Mar 2013   [Refereed]
Novel Mutations of CDKN1C in Japanese Patients with Beckwith-Wiedemann Syndrome.
Yatsuki H, Higashimoto K, Jozaki K, Koide K, Okada J, Watanabe Y, Okamoto N, Tsuno Y, Yoshida Y, Ueda K, Shimizu K, Ohashi H, Mukai T, Soejima H.
Genes & Genomics   35(2) 141-147   2013   [Refereed]
Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract Polycomb silencing.
Miyazaki H†, Higashimoto K†, Yada Y†, A. Endo T¶, Sharif J¶, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, *Nishioka K.(†, ¶ equal contribution)
PLoS Genet.   9(11) e1003897   2013
Comprehensive analyses of imprinted differentially methylated regions reveal epigenetic and genetic characteristics in hepatoblastoma.
Rumbajan JM, Maeda T, Souzaki R, Mitsui K, Higashimoto K, Nakabayashi K, Yatsuki H, Nishioka K, Harada R, Aoki S, Kohashi K, Oda Y, Hata K, Saji T, Taguchi T, Tajiri T, Soejima H, Joh K.
BMC Cancer   13 608   2013
A novel de novo point mutation of the OCT-binding site in the IGF2/H19-imprinting control region in a Beckwith-Wiedemann syndrome patient.
Higashimoto K, Jozaki K, Kosho T, Matsubara K, Fuke T, Yamada D, Yatsuki H, Maeda T, Ohtsuka Y, Nishioka K, Joh K, Koseki H, Ogata T, Soejima H.
Clin Genet.      Dec 2013
Congenital hyperinsulinism in an infant with paternal uniparental disomy on chromosome 11p15: Few clinical features suggestive of Beckwith-Wiedemann syndrome.
*Adachi H, Takahashi I, Higashimoto K, Tsuchida S, Noguchi A, Tamura H, Arai H, Ito T, Masue M, Nishibori H, Takahashi T, Soejima H.
Endocr J.   60(4) 403-408   2013
Homozygous deletion of DIS3L2 exon 9 due to non-allelic homologous recombination between LINE-1s in a Japanese patient with Perlman syndrome.
Higashimoto K, Maeda T, Okada J, Ohtsuka Y, Sasaki K, Hirose A, Nomiyama M, Takayanagi T, Fukuzawa R, Yatsuki H, Koide K, Nishioka K, Joh K, Watanabe Y, Yoshiura K, Soejima H.
Eur J Hum Genet   21(11) 1316-1319   2013
Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract Polycomb silencing.
Miyazaki H, Higashimoto K, Yada Y, Endo TA, Sharif J, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K.
PLoS Genet   9(11) e1003897   2013
*Soma N†, Higashimoto K†, Imamura M, Saitoh A, Soejima H, Nagasaki K. (†: equal contribution)
173(4)    2017   [Refereed]
Hori I, Kawamura R, Nakabayashi K, Watanabe H, Higashimoto K, Tomikawa J, Ieda D, Ohashi K, Negishi Y, Hattori A, Sugio Y, Wakui K, Hata K, Soejima H, Kurosawa K, Saitoh S.
54(12)    2017   [Refereed]
*Kawasaki Y, Makimoto M, Samejima A, Yoneda N, Higashimoto K, Soejima H, Yoshida T
59(5)    2018   [Refereed]
Joh K, Matsuhisa F, Kitajima S, Nishioka K, Higashimoto K, Yatsuki H, Kono T, Koseki H, Soejima H
11(1)    2018   [Refereed]
*Yamada T, Sugiyama G, Higashimoto K, Nakashima A, Nakano H, Sumida T, Soejima H, Mori Y
   2018   [Refereed]
Hidaka H, Higashimoto K, Aoki S, Mishima H, Hayashida C, Maeda T, Koga Y, Yatsuki H, Joh K, Noshiro H, Iwakiri R, Kawaguchi A, Yoshiura KI, Fujimoto K, Soejima H
10(1)    2018   [Refereed]
Novel Mutations of CDKN1C in Japanese Patients with Beckwith-Wiedemann Syndrome.
Yatsuki H, Higashimoto K, Jozaki K, Koide K, Okada J, Watanabe Y, Okamoto N, Tsuno Y, Yoshida Y, Ueda K, Shimizu K, Ohashi H, Mukai T, Soejima H.
Genes Genom   35(2)    2013
Comprehensive analyses of imprinted differentially methylated regions reveal epigenetic and genetic characteristics in hepatoblastoma.
Rumbajan JM, Maeda T, Souzaki R, Mitsui K, Higashimoto K, Nakabayashi K, Yatsuki H, Nishioka K, Harada R, Aoki S, Kohashi K, Oda Y, Hata K, Saji T, Taguchi T, Tajiri T, Soejima H, Joh K.
BMC Cancer   13 608   2013
A novel de novo point mutation of the OCT-binding site in the IGF2/H19-imprinting control region in a Beckwith-Wiedemann syndrome patient.
Higashimoto K, Jozaki K, Kosho T, Matsubara K, Fuke T, Yamada D, Yatsuki H, Maeda T, Ohtsuka Y, Nishioka K, Joh K, Koseki H, Ogata T, Soejima H.
Clin Genet, published online: 4 Dec 2013      2013
A novel de novo point mutation of the OCT-binding site in the IGF2/H19-imprinting control region in a Beckwith-Wiedemann syndrome patient.
Higashimoto K, Jozaki K, Kosho T, Matsubara K, Fuke T, Yamada D, Yatsuki H, Maeda T, Ohtsuka Y, Nishioka K, Joh K, Koseki H, Ogata T, Soejima H.
86(6)    2014   [Refereed]
Novel Nonsense Mutation in the NLRP7 Gene Associated with Recurrent Hydatidiform Mole.
Ito Y, Maehara K, Kaneki E, Matsuoka K, Sugahara N, Miyata T, Kamura H, Yamaguchi Y, Kono A, Nakabayashi K, Migita O, Higashimoto K, Soejima H, Okamoto A, Nakamura H, Kimura T, Wake N, Taniguchi T, Hata K.
   2015   [Refereed]
Autosomal recessive cystinuria caused by genome-wide paternal uniparental isodisomy in a patient with Beckwith-Wiedemann syndrome.
Ohtsuka Y, Higashimoto K, Sasaki K, Jozaki K, Yoshinaga H, Okamoto N, Takama Y, Kubota A, Nakayama M, Yatsuki H, Nishioka K, Joh K, Mukai T, Yoshiura KI, Soejima H.
   2014   [Refereed]
Comprehensive and quantitative multilocus methylation analysis reveals the susceptibility of specific imprinted differentially methylated regions (DMRs) to aberrant methylation in Beckwith-Wiedemann syndrome with epimutations.
Maeda T, Higashimoto K, Jozaki K, Yatsuki H, Nakabayashi K, Makita Y, Tonoki H, Okamoto N, Takada F, Ohashi H, Migita M, Kosaki R, Matsubara K, Ogata T, Matsuo M, Hamasaki Y, Ohtsuka Y, Nishioka K, Joh K, Mukai T, Hata K, Soejima H.
16(12)    2014   [Refereed]
Fibroadenoma in a Beckwith-Wiedemann syndrome with paternal uniparental disomy of chromosome 11p15.5.
*Takama Y, Kubota A, Nakayama M, Higashimoto K, Jozaki K, Soejima H.
56(6)    2014   [Refereed]
Loss of CpG methylation is strongly correlated with loss of histone H3 lysine 9 methylation at DMR-LIT1 in patients with BeckwithWiedemann Syndrome.
Higashimoto K, Urano T, Sugiura K, Yatsuki H, Joh K, Zhao W, Iwakawa M, Ohashi H, Oshimura M, Niikawa N, Mukai T, Soejima H
Am. J. Hum. Genet.   73(4) 948-956   2003
Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT)gene expression in human cancer.
Nakagawachi T, Soejima H, Urano T, Zhao W, Higashimoto K, Satoh Y, Matsukura S, Kudo S, Kitajima Y, Harada H, Furukawa K, Matsuzaki H, Emi M, Nakabeppu Y, Miyazaki K, Sekiguchi M, Mukai T
Oncogene.   22(5) 8835-8844   2003
Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer
Soejima H,Nakagawachi T,Zhao W,Higashimoto K,Urano T,Matsukura S,Kitajima Y,Takeuchi M,Nakayama M,Oshimura M,Miyazaki K,Joh K,Mukai T
Oncogene   23(25) 4380-4388   2004
The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island.
Zhao W., Soejima H., Higashimoto K., Nakagawachi T., Urano T., Kudo S., Matsukura S., Matsuo S., Joh K., & Mukai T.
J. Biochem.   137(3) 431-440   2005
Comparative analyses of genomic imprinting and CpG island-methylation in mouse Murr1 and human MURR1 loci revealed a putative imprinting control region in mice.
Zhang Z., Joh K., Yatsuki H., Wang Y., Arai Y., Soejima H., Higashimoto K., Iwasaka T., Mukai T.
Gene   366(1) 77-86   2006
Japanese and North American/European patients with Beckwith-Wiedemann syndrome have different frequencies of some epigenetic and genetic alterations.
Sasaki K, Soejima H, Higashimoto K, Yatsuki H, Ohashi H, Yakabe S, Joh K, Niikawa N, Mukai T.
Eur. J. Hum. Genet.   15(12) 1205-1210   2007   [Refereed]
Antisense transcription occurs at the promoter of a mouse imprinted gene, commd1, on the repressed paternal allele.
Joh K, Yatsuki H, Higashimoto K, Mukai T, Soejima H.
J Biochem. 146 (6) 771-774.   146(6) 771-774   2009
Aberrant methylation of H19-DMR acquired after implantation was dissimilar in soma versus placenta of patients with Beckwith-Wiedemann syndrome.
Higashimoto K, Nakabayashi K, Yatsuki H, Yoshinaga H, Jozaki K, Okada J, Watanabe Y, Aoki A, Shiozaki A, Saito S, Koide K, Mukai T, Hata K, Soejima H.
Am J Med Genet A.   158A(7) 1670-1675   2012
Congenital hyperinsulinism in an infant with paternal uniparental disomy on chromosome 11p15: Few clinical features suggestive of Beckwith-Wiedemann syndrome.
*Adachi H, Takahashi I, Higashimoto K, Tsuchida S, Noguchi A, Tamura H, Arai H, Ito T, Masue M, Nishibori H, Takahashi T, Soejima H.
Endocr J. [Advance Publication] Released: 2012/11/30      2012
Novel Mutations of CDKN1C in Japanese Patients with Beckwith-Wiedemann Syndrome.
Yatsuki H, Higashimoto K, Jozaki K, Koide K, Okada J, Watanabe Y, Okamoto N, Tsuno Y, Yoshida Y, Ueda K, Shimizu K, Ohashi H, Mukai T, Soejima H.
Genes & Genomics   35(2) 141-147   2013   [Refereed]
Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract Polycomb silencing.
Miyazaki H†, Higashimoto K†, Yada Y†, A. Endo T¶, Sharif J¶, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, *Nishioka K.(†, ¶ equal contribution)
PLoS Genet.   9(11) e1003897   2013
Congenital hyperinsulinism in an infant with paternal uniparental disomy on chromosome 11p15: Few clinical features suggestive of Beckwith-Wiedemann syndrome.
*Adachi H, Takahashi I, Higashimoto K, Tsuchida S, Noguchi A, Tamura H, Arai H, Ito T, Masue M, Nishibori H, Takahashi T, Soejima H.
Endocr J.   60(4) 403-408   2013
Homozygous deletion of DIS3L2 exon 9 due to non-allelic homologous recombination between LINE-1s in a Japanese patient with Perlman syndrome.
Higashimoto K, Maeda T, Okada J, Ohtsuka Y, Sasaki K, Hirose A, Nomiyama M, Takayanagi T, Fukuzawa R, Yatsuki H, Koide K, Nishioka K, Joh K, Watanabe Y, Yoshiura K, Soejima H.
Eur J Hum Genet   21(11) 1316-1319   2013
Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract Polycomb silencing.
Miyazaki H, Higashimoto K, Yada Y, Endo TA, Sharif J, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K.
PLoS Genet   9(11) e1003897   2013
Novel Mutations of CDKN1C in Japanese Patients with Beckwith-Wiedemann Syndrome.
Yatsuki H, Higashimoto K, Jozaki K, Koide K, Okada J, Watanabe Y, Okamoto N, Tsuno Y, Yoshida Y, Ueda K, Shimizu K, Ohashi H, Mukai T, Soejima H.
Genes Genom   35(2)    2013
Comprehensive analyses of imprinted differentially methylated regions reveal epigenetic and genetic characteristics in hepatoblastoma.
Rumbajan JM, Maeda T, Souzaki R, Mitsui K, Higashimoto K, Nakabayashi K, Yatsuki H, Nishioka K, Harada R, Aoki S, Kohashi K, Oda Y, Hata K, Saji T, Taguchi T, Tajiri T, Soejima H, Joh K.
BMC Cancer   13 608   2013
A novel de novo point mutation of the OCT-binding site in the IGF2/H19-imprinting control region in a Beckwith-Wiedemann syndrome patient.
Higashimoto K, Jozaki K, Kosho T, Matsubara K, Fuke T, Yamada D, Yatsuki H, Maeda T, Ohtsuka Y, Nishioka K, Joh K, Koseki H, Ogata T, Soejima H.
Clin Genet, published online: 4 Dec 2013      2013
A novel de novo point mutation of the OCT-binding site in the IGF2/H19-imprinting control region in a Beckwith-Wiedemann syndrome patient.
Higashimoto K, Jozaki K, Kosho T, Matsubara K, Fuke T, Yamada D, Yatsuki H, Maeda T, Ohtsuka Y, Nishioka K, Joh K, Koseki H, Ogata T, Soejima H.
86(6)    2014   [Refereed]
Novel Nonsense Mutation in the NLRP7 Gene Associated with Recurrent Hydatidiform Mole.
Ito Y, Maehara K, Kaneki E, Matsuoka K, Sugahara N, Miyata T, Kamura H, Yamaguchi Y, Kono A, Nakabayashi K, Migita O, Higashimoto K, Soejima H, Okamoto A, Nakamura H, Kimura T, Wake N, Taniguchi T, Hata K.
   2015   [Refereed]
Autosomal recessive cystinuria caused by genome-wide paternal uniparental isodisomy in a patient with Beckwith-Wiedemann syndrome.
Ohtsuka Y, Higashimoto K, Sasaki K, Jozaki K, Yoshinaga H, Okamoto N, Takama Y, Kubota A, Nakayama M, Yatsuki H, Nishioka K, Joh K, Mukai T, Yoshiura KI, Soejima H.
   2014   [Refereed]
Comprehensive and quantitative multilocus methylation analysis reveals the susceptibility of specific imprinted differentially methylated regions (DMRs) to aberrant methylation in Beckwith-Wiedemann syndrome with epimutations.
Maeda T, Higashimoto K, Jozaki K, Yatsuki H, Nakabayashi K, Makita Y, Tonoki H, Okamoto N, Takada F, Ohashi H, Migita M, Kosaki R, Matsubara K, Ogata T, Matsuo M, Hamasaki Y, Ohtsuka Y, Nishioka K, Joh K, Mukai T, Hata K, Soejima H.
16(12)    2014   [Refereed]
Fibroadenoma in a Beckwith-Wiedemann syndrome with paternal uniparental disomy of chromosome 11p15.5.
*Takama Y, Kubota A, Nakayama M, Higashimoto K, Jozaki K, Soejima H.
56(6)    2014   [Refereed]
Loss of CpG methylation is strongly correlated with loss of histone H3 lysine 9 methylation at DMR-LIT1 in patients with BeckwithWiedemann Syndrome.
Higashimoto K, Urano T, Sugiura K, Yatsuki H, Joh K, Zhao W, Iwakawa M, Ohashi H, Oshimura M, Niikawa N, Mukai T, Soejima H
Am. J. Hum. Genet.   73(4) 948-956   2003
Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT)gene expression in human cancer.
Nakagawachi T, Soejima H, Urano T, Zhao W, Higashimoto K, Satoh Y, Matsukura S, Kudo S, Kitajima Y, Harada H, Furukawa K, Matsuzaki H, Emi M, Nakabeppu Y, Miyazaki K, Sekiguchi M, Mukai T
Oncogene.   22(5) 8835-8844   2003
Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer
Soejima H,Nakagawachi T,Zhao W,Higashimoto K,Urano T,Matsukura S,Kitajima Y,Takeuchi M,Nakayama M,Oshimura M,Miyazaki K,Joh K,Mukai T
Oncogene   23(25) 4380-4388   2004
The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island.
Zhao W., Soejima H., Higashimoto K., Nakagawachi T., Urano T., Kudo S., Matsukura S., Matsuo S., Joh K., & Mukai T.
J. Biochem.   137(3) 431-440   2005
Comparative analyses of genomic imprinting and CpG island-methylation in mouse Murr1 and human MURR1 loci revealed a putative imprinting control region in mice.
Zhang Z., Joh K., Yatsuki H., Wang Y., Arai Y., Soejima H., Higashimoto K., Iwasaka T., Mukai T.
Gene   366(1) 77-86   2006
Japanese and North American/European patients with Beckwith-Wiedemann syndrome have different frequencies of some epigenetic and genetic alterations.
Sasaki K, Soejima H, Higashimoto K, Yatsuki H, Ohashi H, Yakabe S, Joh K, Niikawa N, Mukai T.
Eur. J. Hum. Genet.   15(12) 1205-1210   2007   [Refereed]
Antisense transcription occurs at the promoter of a mouse imprinted gene, commd1, on the repressed paternal allele.
Joh K, Yatsuki H, Higashimoto K, Mukai T, Soejima H.
J Biochem. 146 (6) 771-774.   146(6) 771-774   2009
Aberrant methylation of H19-DMR acquired after implantation was dissimilar in soma versus placenta of patients with Beckwith-Wiedemann syndrome.
Higashimoto K, Nakabayashi K, Yatsuki H, Yoshinaga H, Jozaki K, Okada J, Watanabe Y, Aoki A, Shiozaki A, Saito S, Koide K, Mukai T, Hata K, Soejima H.
Am J Med Genet A.   158A(7) 1670-1675   2012
Congenital hyperinsulinism in an infant with paternal uniparental disomy on chromosome 11p15: Few clinical features suggestive of Beckwith-Wiedemann syndrome.
*Adachi H, Takahashi I, Higashimoto K, Tsuchida S, Noguchi A, Tamura H, Arai H, Ito T, Masue M, Nishibori H, Takahashi T, Soejima H.
Endocr J. [Advance Publication] Released: 2012/11/30      2012
Novel Mutations of CDKN1C in Japanese Patients with Beckwith-Wiedemann Syndrome.
Yatsuki H, Higashimoto K, Jozaki K, Koide K, Okada J, Watanabe Y, Okamoto N, Tsuno Y, Yoshida Y, Ueda K, Shimizu K, Ohashi H, Mukai T, Soejima H.
Genes & Genomics   35(2) 141-147   2013   [Refereed]
Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract Polycomb silencing.
Miyazaki H†, Higashimoto K†, Yada Y†, A. Endo T¶, Sharif J¶, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, *Nishioka K.(†, ¶ equal contribution)
PLoS Genet.   9(11) e1003897   2013
Congenital hyperinsulinism in an infant with paternal uniparental disomy on chromosome 11p15: Few clinical features suggestive of Beckwith-Wiedemann syndrome.
*Adachi H, Takahashi I, Higashimoto K, Tsuchida S, Noguchi A, Tamura H, Arai H, Ito T, Masue M, Nishibori H, Takahashi T, Soejima H.
Endocr J.   60(4) 403-408   2013
Homozygous deletion of DIS3L2 exon 9 due to non-allelic homologous recombination between LINE-1s in a Japanese patient with Perlman syndrome.
Higashimoto K, Maeda T, Okada J, Ohtsuka Y, Sasaki K, Hirose A, Nomiyama M, Takayanagi T, Fukuzawa R, Yatsuki H, Koide K, Nishioka K, Joh K, Watanabe Y, Yoshiura K, Soejima H.
Eur J Hum Genet   21(11) 1316-1319   2013
Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract Polycomb silencing.
Miyazaki H, Higashimoto K, Yada Y, Endo TA, Sharif J, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K.
PLoS Genet   9(11) e1003897   2013
Novel Mutations of CDKN1C in Japanese Patients with Beckwith-Wiedemann Syndrome.
Yatsuki H, Higashimoto K, Jozaki K, Koide K, Okada J, Watanabe Y, Okamoto N, Tsuno Y, Yoshida Y, Ueda K, Shimizu K, Ohashi H, Mukai T, Soejima H.
Genes Genom   35(2)    2013
Comprehensive analyses of imprinted differentially methylated regions reveal epigenetic and genetic characteristics in hepatoblastoma.
Rumbajan JM, Maeda T, Souzaki R, Mitsui K, Higashimoto K, Nakabayashi K, Yatsuki H, Nishioka K, Harada R, Aoki S, Kohashi K, Oda Y, Hata K, Saji T, Taguchi T, Tajiri T, Soejima H, Joh K.
BMC Cancer   13 608   2013
A novel de novo point mutation of the OCT-binding site in the IGF2/H19-imprinting control region in a Beckwith-Wiedemann syndrome patient.
Higashimoto K, Jozaki K, Kosho T, Matsubara K, Fuke T, Yamada D, Yatsuki H, Maeda T, Ohtsuka Y, Nishioka K, Joh K, Koseki H, Ogata T, Soejima H.
Clin Genet, published online: 4 Dec 2013      2013
A novel de novo point mutation of the OCT-binding site in the IGF2/H19-imprinting control region in a Beckwith-Wiedemann syndrome patient.
Higashimoto K, Jozaki K, Kosho T, Matsubara K, Fuke T, Yamada D, Yatsuki H, Maeda T, Ohtsuka Y, Nishioka K, Joh K, Koseki H, Ogata T, Soejima H.
86(6)    2014   [Refereed]
Novel Nonsense Mutation in the NLRP7 Gene Associated with Recurrent Hydatidiform Mole.
Ito Y, Maehara K, Kaneki E, Matsuoka K, Sugahara N, Miyata T, Kamura H, Yamaguchi Y, Kono A, Nakabayashi K, Migita O, Higashimoto K, Soejima H, Okamoto A, Nakamura H, Kimura T, Wake N, Taniguchi T, Hata K.
   2015   [Refereed]
Autosomal recessive cystinuria caused by genome-wide paternal uniparental isodisomy in a patient with Beckwith-Wiedemann syndrome.
Ohtsuka Y, Higashimoto K, Sasaki K, Jozaki K, Yoshinaga H, Okamoto N, Takama Y, Kubota A, Nakayama M, Yatsuki H, Nishioka K, Joh K, Mukai T, Yoshiura KI, Soejima H.
   2014   [Refereed]
Comprehensive and quantitative multilocus methylation analysis reveals the susceptibility of specific imprinted differentially methylated regions (DMRs) to aberrant methylation in Beckwith-Wiedemann syndrome with epimutations.
Maeda T, Higashimoto K, Jozaki K, Yatsuki H, Nakabayashi K, Makita Y, Tonoki H, Okamoto N, Takada F, Ohashi H, Migita M, Kosaki R, Matsubara K, Ogata T, Matsuo M, Hamasaki Y, Ohtsuka Y, Nishioka K, Joh K, Mukai T, Hata K, Soejima H.
16(12)    2014   [Refereed]
Fibroadenoma in a Beckwith-Wiedemann syndrome with paternal uniparental disomy of chromosome 11p15.5.
*Takama Y, Kubota A, Nakayama M, Higashimoto K, Jozaki K, Soejima H.
56(6)    2014   [Refereed]
Loss of CpG methylation is strongly correlated with loss of histone H3 lysine 9 methylation at DMR-LIT1 in patients with BeckwithWiedemann Syndrome.
Higashimoto K, Urano T, Sugiura K, Yatsuki H, Joh K, Zhao W, Iwakawa M, Ohashi H, Oshimura M, Niikawa N, Mukai T, Soejima H
Am. J. Hum. Genet.   73(4) 948-956   2003
Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT)gene expression in human cancer.
Nakagawachi T, Soejima H, Urano T, Zhao W, Higashimoto K, Satoh Y, Matsukura S, Kudo S, Kitajima Y, Harada H, Furukawa K, Matsuzaki H, Emi M, Nakabeppu Y, Miyazaki K, Sekiguchi M, Mukai T
Oncogene.   22(5) 8835-8844   2003
Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer
Soejima H,Nakagawachi T,Zhao W,Higashimoto K,Urano T,Matsukura S,Kitajima Y,Takeuchi M,Nakayama M,Oshimura M,Miyazaki K,Joh K,Mukai T
Oncogene   23(25) 4380-4388   2004
The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island.
Zhao W., Soejima H., Higashimoto K., Nakagawachi T., Urano T., Kudo S., Matsukura S., Matsuo S., Joh K., & Mukai T.
J. Biochem.   137(3) 431-440   2005
Comparative analyses of genomic imprinting and CpG island-methylation in mouse Murr1 and human MURR1 loci revealed a putative imprinting control region in mice.
Zhang Z., Joh K., Yatsuki H., Wang Y., Arai Y., Soejima H., Higashimoto K., Iwasaka T., Mukai T.
Gene   366(1) 77-86   2006

Misc

 
Ⅱ各論 1.症候群(3)Beckwith-Wiedemann syndrome
73(増刊号6)    2015
[6] Beckwith-Wiedemann症候群 (BWS)
31(suppl-2)    2015
Beckwith-Wiedemann症候群
50(7) 1046-1052   2009
日本小児血液学会雑誌
22(3) 139-143   2008
Acute megakaryocytic leukemia (AMKL, FAB; M7) with Beckwith-Wiedemann syndrome.
Yamamoto S, Toyama D, Yatsuki H, Higashimoto K, Soejima H, Isoyama K
Pediatr Blood Cancer   55(4) 733-735   2010

Books etc

 
Beckwith-Wiedemann症候群と小児腫瘍
2013   
Beckwith-Wiedemann症候群
2014   
第7章 non-coding RNA の構造と機能
Sep 2004   
Genomic Imprinting Syndromes and Cancer
Higashimoto K, Joh K, Soejima H.
New York, Humana Press   2017   

Conference Activities & Talks

 
DNAメチル化異常不一致を示す一卵性2絨毛膜2羊膜双胎のBeckwith-Wiedemann syndrome
2016   
間葉性異形成胎盤のゲノム・エピゲノム解析
2016   
DIS3L2複合ヘテロ変異を同定した長期生存Perlman症候群の1例
2016   
ソトス症候群とベックウィズ・ビーデマン症候群でオーバーラップする表現型の原因探索
2016   
NSD1ハプロ不全はDNAメチル化インプリント異常と遺伝子発現異常を惹起する
2016   

Association Memberships