Masakazu Nitta

Profile Information

Affiliation: School of Medicine, School of Medicine, Aichi Medical University

Degree: (BLANK)(Nagoya City University)

J-GLOBAL ID: 200901025538202607
researchmap Member ID: 1000305245

Research Interests

Research Areas

Life sciences / Hematology and oncology /

Committee Memberships

Papers

Cyclin-dependent kinase 9 as a potential specific molecular target in NK cell leukemia/lymphoma.

Kinoshita S, Ishida T, Ito A, Narita T, Masaki A, Suzuki S, Yoshida T, Ri M, Kusumoto S, Komatsu H …

Haematologica, 103(12) 2059-2068, Aug, 2018 Peer-reviewed
Clinical significance of tryptophan catabolism in Hodgkin lymphoma.

Masaki A, Ishida T, Maeda Y, Ito A, Suzuki S, Narita T, Kinoshita S, Takino H, Yoshida T, Ri M …

Cancer science, 109(1) 74-83, Jan, 2018 Peer-reviewed
MYCおよびPVT1を含む8q24領域にHSRを有する新規DLBCL細胞株の樹立(Establishment of a novel DLBCL cell line, AMU-ML-2, carrying HSR on 8q24 containing MYC and PVT1)

Mizuno Shohei, Hanamura Ichiro, Ota Akinobu, Sivasundaram Karnan, Utino Kaori, Horio Tomohiro, Mizutani Motonori, Goto Mineaki, Takahashi Miyuki, Gotou Mayuko …

臨床血液, 56(9) 1576-1576, Sep, 2015
Amylase-Producing Myeloma Cells Reduced Sensitivity to Dexamethasone and Bortezomib.

Mizuno Shohei, Hanamura Ichiro, Ota Akinobu, Sivasundaram Karnan, Narita Tomoko, Ri Masaki, Mizutani Motonori, Goto Mineaki, Gotou Mayuko, Tsunekawa Norikazu …

BLOOD, 124(21), Dec 6, 2014 Peer-reviewed
Adaptation of leukemia cells to hypoxic condition through switching the energy metabolism or avoiding the oxidative stress.

Mineaki Goto, Hiroshi Miwa, Kazuto Suganuma, Norikazu Tsunekawa-Imai, Masato Shikami, Motonori Mizutani, Shohei Mizuno, Ichiro Hanamura, Masakazu Nitta

BMC cancer, 14 76-76, Feb 10, 2014 Peer-reviewed
Growth of xenotransplanted leukemia cells is influenced by diet nutrients and is attenuated with 2-deoxyglucose.

Norikazu Tsunekawa-Imai, Hiroshi Miwa, Masato Shikami, Kazuto Suganuma, Mineaki Goto, Shohei Mizuno, Miyuki Takahashi, Motonori Mizutani, Tomohiro Horio, Hiroko Komatsubara …

Leukemia research, 37(9) 1132-6, Sep, 2013 Peer-reviewed
再発性骨髄腫患者における続発性形質細胞性白血病のゲノムレベル解析(Genome-wide analysis of secondary plasma cell leukemia in a relapsed myeloma patient)

Mizuno Shohei, Hanamura Ichiro, Mizutani Motonori, Goto Mineaki, Tsunekawa Norikazu, Wakabayashi Motohiro, Ota Akinobu, Sivasundaram Karnan, Shikami Masato, Hosokawa Yoshitaka …

臨床血液, 54(9) 1328-1328, Sep, 2013
Leukemia cells demonstrate a different metabolic perturbation provoked by 2-deoxyglucose.

Hiroshi Miwa, Masato Shikami, Mineaki Goto, Shohei Mizuno, Miyuki Takahashi, Norikazu Tsunekawa-Imai, Takamasa Ishikawa, Motonori Mizutani, Tomohiro Horio, Mayuko Gotou …

Oncology reports, 29(5) 2053-7, May, 2013 Peer-reviewed
DLBCLにおいてc-MYCとPVT1を含む8q24上のHSRで同定された1.4 Mb単位複製配列 1症例報告(Identification of a 1.4 Mb-amplicon in HSR on 8q24 containing c-MYC and PVT1 in DLBCL: A case report)

Mizuno Shohei, Hanamura Ichiro, Horio Tomohiro, Goto Mineaki, Gotou Mayuko, Hiramatu Akihito, Watarai Masaya, Takahashi Emiko, Ota Akinobu, Karnan Sivasundaram …

臨床血液, 53(9) 1371-1371, Sep, 2012
三酸化砒素はTRIF依存性経路を抑制しLPS刺激後のRAW264.7細胞からの一酸化窒素の産生を阻害する(Arsenic trioxide inhibited the NO production in LPS-stimulated RAW 264.7 cells by preventing the TRIF dependent pathway)

高橋美裕希, 太田明伸, Sivasundaram Karnan, 小西裕之, 花村一朗, 三輪啓志, 仁田正和, 細川好孝

日本癌学会総会記事, 71回 153-153, Aug, 2012
The Asn505 mutation of the c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimerization of the c-Mpl protein due to strong amino acid polarity

Jianmin Ding, Hirokazu Komatsu, Shinsuke Iida, Hiroki Yano, Shigeru Kusumoto, Atsushi Inagaki, Fumiko Mori, Masaki Ri, Asahi Ito, Atsushi Wakita …

BLOOD, 114(15) 3325-3328, Oct, 2009 Peer-reviewed
[The role of physicians in charge of cancer chemotherapy in oncological management].

Kusumoto S, Komatsu H, Ueda R

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 98(8) 1947-1951, Aug, 2009
染色体転座関連原癌遺伝子の発現定量解析に基づく多発性骨髄腫発症機序の解明

加藤美幸, 飯田真介, 小松弘和, 石田高司, 花村一朗, 粥川哲, 速水芳仁, 片岡孝江, 大槻剛巳, 仁田正和

臨床血液, 44(8) 648-648, Aug, 2003
早期plasma cell dyscrasiaの発症に関与する14q32の同定

三浦和久, 飯田真介, 花村一朗, 稲垣宏, 野村憲一, 石田高司, 小松弘和, 坂野章吾, 脇田充史, 楠本茂 …

臨床血液, 43(8) 187-187, Aug, 2002

Misc.

MM細胞株を用いた異所性アミラーゼ安定的発現株の樹立とその性状解析

水野昌平, 花村一朗, 太田明伸, SIVASUNDARAM Karnan, 成田朋子, 李政樹, 後藤峰明, 後藤麻友子, 恒川敬和, 爾見雅人 …

Int J Myeloma (Web), 4(2) O-1 (WEB ONLY)-66, 2014
ROSは低酸素症下の白血病細胞増殖において重要な役割を果たす(ROS has a key role in proliferation of leukemia cells under hypoxia)

Goto Mineaki, Miwa Hiroshi, Shikami Masato, Tsunekawa Norikazu, Suganuma Kazuto, Uchino Kaori, Horio Tomohiro, Mizutani Motonori, Takahashi Miyuki, Mizuno Shohei …

臨床血液, 54(9) 1203-1203, Sep, 2013
単施設での超高齢リンパ腫患者の後向き臨床解析(A retrospective clinical analysis of very elderly patients with lymphoma in a single institute)

Yamamoto Hidesuke, Hanamura Ichiro, Uchino Kaori, Mizutani Motonori, Horio Tomohiro, Takahashi Miyuki, Mizuno Shohei, Goto Mineaki, Goto Mayuko, Tsunekawa Norikazu …

臨床血液, 54(9) 1286-1286, Sep, 2013
2-deoxy-D-glucoseを投与されたNOD/scidマウスにおける白血病細胞の代謝スイッチ(Metabolic switch of leukemia cells in NOD/scid mice treated by 2-deoxy-D-glucose)

Tsunekawa Norikazu, Miwa Hiroshi, Mizutani Motonori, Komatsubara Hiroko, Horio Tomohiro, Goto Mineaki, Mizuno Shohei, Takahashi Miyuki, Suganuma Kazuto, Gotou Mayuko …

臨床血液, 53(9) 1043-1043, Sep, 2012
THP1は低酸素下でPDK1上方調節を介した代謝変化により増殖能を高める(The growth of THP1 is increased under hypoxia by changing metabolism through PDK1 upregulation)

Goto Mineaki, Miwa Hiroshi, Komatsubara Hiroko, Horio Tomohiro, Mizutani Motonori, Takahashi Miyuki, Mizuno Shohei, Suganuma Kazuto, Gotou Mayuko, Tsunekawa Norikazu …

臨床血液, 53(9) 1192-1192, Sep, 2012
赤血球過形成を伴うAMLの臨床的特徴(Clinical manifestation of AML with erythroid hyperplasia)

Shikami Masato, Horio Tomohiro, Hiramatsu Akihito, Watarai Masaya, Gotou Mayuko, Goto Mineaki, Takahashi Miyuki, Mizuno Shohei, Komatubara Hiroko, Mizutani Motonori …

臨床血液, 53(9) 1195-1195, Sep, 2012
愛知医科大学におけるホジキンリンパ腫の後向き臨床解析(Retrospective clinical analysis of Hodgkin lymphoma in Aichi Medical University)

Yamamoto Hidesuke, Hanamura Ichiro, Mizutani Motonori, Komatsubara Yoko, Horio Tomohiro, Takahashi Miyuki, Mizuno Shohei, Goto Mineaki, Gotou Mayuko, Suganuma Kazuto …

臨床血液, 53(9) 1348-1348, Sep, 2012
心嚢液および骨髄浸潤にて発症したt(3;8;14)(q27;q24;q32)とt(2;18)(p12;q21)とを有したtriple hit lymphomaの一例

山本英督, 花村一朗, 渡会雅也, 後藤麻友子, 高橋美裕希, 榎本めぐみ, 清水宏伸, 恒川敬和, 高橋恵美子, 爾見雅人 …

日本リンパ網内系学会会誌, 52 115-115, May, 2012
AML細胞株(glycolysis、TCAサイクル、pentose phosphate経路)のメタボロミクス解析(Metabolomic analysis of AML cell lines (glycolysis, TCA cycle and pentose phosphate pathway))

Miwa Hiroshi, Shikami Masato, Tsunekawa Norikazu, Suganuma Kazuto, Goto Mineaki, Takahashi Miyuki, Mizuno Shohei, Horio Tomohiro, Hanamura Ichiro, Nitta Masakazu

臨床血液, 52(9) 1116-1116, Sep, 2011
RA患者10名におけるMTX関連リンパ増殖性疾患の臨床病理学的分析(Clinicopathlogical analysis of MTX related lymphoproliferative disorder in 10 patients with RA)

Yamamoto Hidesuke, Banno Syogo, Takahashi Emiko, Horio Tomohiro, Takahashi Miyuki, Mizuno Syohei, Goto Mineaki, Gotou Mayuko, Watarai Masaya, Hanamura Ichiro …

臨床血液, 52(9) 1285-1285, Sep, 2011
経時的な定量的MLL-AF6キメラtranscriptの測定が白血病病状把握に有用であったAML M5bの一例

山本英督, 花村一朗, 渡会雅也, 高橋美裕希, 水野昌平, 後藤峰明, 後藤麻友子, 菅沼和人, 今井敬和, 平松明人 …

日本造血細胞移植学会総会プログラム・抄録集, 33rd, 2011
新しいヒト骨髄性白血病細胞株AMU-AML1の樹立および解析(Establishment and characterization of a novel human myeloid leukemia cell line, AMU-AML1)

Gotou Mayuko, Wakabayashi Motohiro, Hanamura Ichiro, Nagoshi Hisao, Taki Tomohiko, Sakamoto Natsumi, Goto Mineaki, Mizuno Shohei, Takahashi Miyuki, Suganuma Kazuto …

臨床血液, 51(9) 1224-1224, Sep, 2010
異なる三つのサブクローンを有する濾胞性リンパ腫症例の分子生物学的解析(Molecular analysis of the case of follicular lymphoma with three different subclones)

Goto Mineaki, Shikami Masato, Hiramatsu Akihito, Miwa Hiroshi, Hanamura Ichirou, Shimizu Hironobu, Iwabuchi Hidehito, Yokoi Toyoharu, Nitta Masakazu

臨床血液, 51(9) 1247-1247, Sep, 2010
長期寛解後に再発をきたした急性骨髄性白血病の2例

今村明, 平松明人, 若林基弘, 今井敬和, 山本英督, 渡会雅也, 花村一朗, 爾見雅人, 三原英嗣, 三輪啓志 …

臨床血液, 51(9) 1126-1126, Sep, 2010
多発性骨髄腫細胞株における新規キメラ遺伝子PVT1-NBEA(BCL8B)の同定(Identification of novel chimeric gene PVT1-NBEA(BCL8B) in a multiple myeloma cell line with t(8;13)(q24;q13))

名越久朗, 滝智彦, 花村一朗, 黒田純也, 西田一弘, 小林覚, 堤康彦, 古林勉, 松本洋典, 堀池重夫 …

日本癌学会総会記事, 69回 83-83, Aug, 2010
Energy Metabolism of Leukemia Cells: Glycolysis Vs Oxidative Phosphorylation

Hiroshi Miwa, Kazuto Suganuma, Masato Shikami, Norikazu Imai, Mayuko Sakai, Akihito Hiramatsu, Hidesuke Yamamoto, Motohiro Wakabayashi, Masaya Watarai, Ichiro Hanamura …

BLOOD, 112(11) 1009-1010, Nov, 2008
急性骨髄性白血病細胞における解糖系優位のエネルギー代謝について

菅沼和人, 三輪啓志, 今井敬和, 爾見雅人, 後藤麻友子, 平松明人, 山本英督, 若林基弘, 渡会雅也, 花村一朗 …

臨床血液, 49(9) 1199-1199, Sep, 2008
Mutational analysis of thrombopietin, c-MPL and Jak2 genes in essential thrombothethymia patients - Identification of concurrent mutations of c-MPL and Jak2

Jianmin Ding, Hirokazu Komatsu, Shinsuke Iida, Asahi Ito, Hiroki Yano, Masaki Ri, Atsushi Inagaki, Shigeru Kusumoto, Takashi Ishida, Masakazu Nitta …

BLOOD, 110(11) 238B-238B, Nov, 2007
抗VEGF受容体中和抗体のAML細胞への効果は核型特異的である

今井敬和, 三輪啓志, 爾見雅人, 菅沼和人, 酒井麻友子, 平松明人, 若林基弘, 渡会雅也, 花村一朗, 今村明 …

臨床血液, 48(9) 876-876, Sep, 2007
治療抵抗性成人T細胞性白血病/リンパ腫に対し、HLA一致同胞間RISTが有効である

爾見雅人, 若林基弘, 平松明人, 今井敬和, 酒井麻友子, 菅沼和人, 渡會雅也, 花村一朗, 今村明, 三原英嗣 …

臨床血液, 48(9) 1023-1023, Sep, 2007

Professional Memberships

Research Projects

造血器腫瘍の化学療法,サイトカイン療法,造血幹細胞移植

1997 - 2004
造血器腫瘍における転写因子とその異常

1997 - 2004
造血幹細胞の発生・分化のメカニズム

1997 - 2004
Chemocherapy, Cytokine therapy and stem cell transplantation in hematological malignancies

1997 - 2004
Transcription factor in hematological malignancies

1997 - 2004
Mechanism of occurrence and differentiation of hematopoietic cell

1997 - 2004

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