Masufumi Takiguchi

Profile Information

Affiliation: Professor, Faculty of Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Hiroshima International University

Degree: Doctor of Philosophy.(Nagasaki University)

J-GLOBAL ID: 200901019384147225
researchmap Member ID: 1000305404

External link: http://www.hirokoku.jp/yy/TopPage/index.html

Research Interests

Research Areas

Life sciences / Pharmaceuticals - health and biochemistry /

Research History

2013 - Present

Professor, Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences, Hiroshima International University
2004 - 2013

Associate Professor, Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences, Hiroshima International University
2000 - 2004

Faculty of Pharmaceutical Sciences, Tokushima Bunri University
2000

米国国立ガン研究所, 日本学術振興会特別研究員
1997 - 1999

米国国立環境保健科学研究所内米国国立ガン研究所博士研究員
1997 - 1999

National Cancer Institute in National Institute of Environmental Health Science

Education

Committee Memberships

Feb, 2021 - Present

日本薬学会代議員
Feb, 2020 - Present

支部幹事, 日本薬学会中国四国支部
Jun, 2018 - Present

呉市廃棄物審議会委員
Feb, 2022 - Jan, 2023

庶務担当幹事, 日本薬学会中国四国支部
Nov, 2012 - Nov, 2020

広島大学ヒトゲノム・遺伝子解析研究倫理審査委員会実地調査担当者, 広島大学ヒトゲノム・遺伝子解析研究倫理審査委員会

Awards

Papers

2-Methoxyestradiol as an Antiproliferative Agent for Long-Term Estrogen-Deprived Breast Cancer Cells.

Masayo Hirao-Suzuki, Koki Kanameda, Masufumi Takiguchi, Narumi Sugihara, Shuso Takeda

Current issues in molecular biology, 45(9) 7336-7351, Sep 9, 2023
Repeated exposure to 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) accelerates ligand-independent activation of estrogen receptors in long-term estradiol-deprived MCF-7 cells.

Masayo Hirao-Suzuki, Masufumi Takiguchi, Shin'ichi Yoshihara, Shuso Takeda

Toxicology letters, 378 31-38, Apr 1, 2023
Cannabidiolic acid activates the expression of the PPARβ/δ target genes in MDA-MB-231 cells

Masayo Hirao-Suzuki, Koga Takayuki, Masufumi Takiguchi, Jeffrey M. Peters, Shuso Takeda

Archives of Biochemistry and Biophysics, 731 109428-109428, Nov, 2022
Perfluorooctanoic acid (PFOA) as a stimulator of estrogen receptor-negative breast cancer MDA-MB-231 cell aggressiveness: Evidence for involvement of fatty acid 2-hydroxylase (FA2H) in the stimulated cell migration.

Genki Sakai, Masayo Hirao-Suzuki, Takayuki Koga, Takananobu Kobayashi, Jun Kamishikiryo, Michitaka Tanaka, Kiyonaga Fujii, Masufumi Takiguchi, Narumi Sugihara, Akihisa Toda …

The Journal of toxicological sciences, 47(4) 159-168, 2022 Peer-reviewed
Effects of the ethanol extract of Neopyropia yezoensis, cultivated in the Seto Inland Sea (Setonaikai), on the viability of 10 human cancer cells including endocrine therapy-resistant breast cancer cells

Shuso Takeda, Masayo Hirao-Suzuki, Yukimasa Yamagishi, Takahiro Sugihara, Masataka Kaneko, Genki Sakai, Tetsuya Nakamura, Yuhzo Hieda, Masufumi Takiguchi, Masahiro Okada …

Fundamental Toxicological Sciences, 8(3) 75-80, 2021 Peer-reviewed
4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) Targets Estrogen Receptor β, to Evoke the Resistance of Human Breast Cancer MCF-7 Cells to G-1, an Agonist for G Protein-Coupled Estrogen Receptor 1.

Masayo Hirao-Suzuki, Keita Nagase, Tatsuya Suemori, Kana Tsutsumi, Egao Shigemori, Michitaka Tanaka, Masufumi Takiguchi, Narumi Sugihara, Shin'ichi Yoshihara, Shuso Takeda

Biological & pharmaceutical bulletin, 44(10) 1524-1529, 2021 Peer-reviewed
Cadmium-stimulated invasion of rat liver cells during malignant transformation: Evidence of the involvement of oxidative stress/TET1-sensitive machinery

Masayo Hirao-Suzuki, Shuso Takeda, Genki Sakai, Michael P. Waalkes, Narumi Sugihara, Masufumi Takiguchi

Toxicology, 152631-152631, Nov, 2020 Peer-reviewedLast authorCorresponding author
Fatty acid 2-hydroxylase (FA2H) as a stimulatory molecule responsible for breast cancer cell migration.

Masayo Hirao-Suzuki, Takayuki Koga, Genki Sakai, Takanobu Kobayashi, Yuji Ishii, Hiroshi Miyazawa, Masufumi Takiguchi, Narumi Sugihara, Akihisa Toda, Masahiro Ohara …

Biochemical and biophysical research communications, 531(2) 215-222, Oct 15, 2020 Peer-reviewed
Metalloestrogenic effects of cadmium are absent in long-term estrogen-deprived MCF-7 cells: Evidence for the involvement of constitutively activated estrogen receptor α and very low expression of G protein-coupled estrogen receptor 1.

Masayo Hirao-Suzuki, Shuso Takeda, Yasushi Kodama, Masufumi Takiguchi, Akihisa Toda, Masahiro Ohara

Toxicology letters, 319 22-30, Feb 1, 2020 Peer-reviewed
Cannabidiolic acid dampens the expression of cyclooxygenase-2 in MDA-MB-231 breast cancer cells: Possible implication of the peroxisome proliferator-activated receptor β/δ abrogation.

Masayo Hirao-Suzuki, Shuso Takeda, Takayuki Koga, Masufumi Takiguchi, Akihisa Toda

The Journal of toxicological sciences, 45(4) 227-236, 2020 Peer-reviewed
Repeated Exposure to 4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), an Active Metabolite of Bisphenol A, Aggressively Stimulates Breast Cancer Cell Growth in an Estrogen Receptor β (ERβ)-Dependent Manner.

Masayo Hirao-Suzuki, Shuso Takeda, Katsuhiro Okuda, Masufumi Takiguchi, Shin'ichi Yoshihara

Molecular pharmacology, 95(3) 260-268, Mar, 2019 Peer-reviewed
Δ9-Tetrahydrocannabinol upregulates fatty acid 2-hydroxylase (FA2H) via PPARα induction: A possible evidence for the cancellation of PPARβ/δ-mediated inhibition of PPARα in MDA-MB-231 cells.

Masayo Hirao-Suzuki, Shuso Takeda, Kazuhito Watanabe, Masufumi Takiguchi, Hironori Aramaki

Archives of biochemistry and biophysics, 662 219-225, Feb 15, 2019 Peer-reviewed
Bisphenol AF as an activator of human estrogen receptor β1 (ERβ1) in breast cancer cell lines.

Hiroyuki Okazaki, Masayo Hirao-Suzuki, Shuso Takeda, Yukimi Takemoto, Ramu Mizunoe, Koichi Haraguchi, Kazuhito Watanabe, Masufumi Takiguchi, Hironori Aramaki

The Journal of toxicological sciences, 43(5) 321-327, 2018 Peer-reviewed
Cadmium down-regulates apolipoprotein E (ApoE) expression during malignant transformation of rat liver cells: direct evidence for DNA hypermethylation in the promoter region of ApoE.

Masayo Hirao-Suzuki, Shuso Takeda, Takanobu Kobayashi, Katsuhito Kino, Hiroshi Miyazawa, Michael P Waalkes, Masufumi Takiguchi

The Journal of toxicological sciences, 43(9) 537-543, 2018
Cannabidiolic Acid-Mediated Interference with AP-1 Transcriptional Activity in MDA-MB-231 Breast Cancer Cells

Masayo Suzuki, Shuso Takeda, Hiroyuki Okazaki, Kazuhito Watanabe, Masufumi Takiguchi, Hironori Aramaki

NATURAL PRODUCT COMMUNICATIONS, 12(5) 759-761, May, 2017 Peer-reviewed
Cadmium-induced malignant transformation of rat liver cells: Potential key role and regulatory mechanism of altered apolipoprotein E expression in enhanced invasiveness

Masayo Suzuki, Shuso Takeda, Noriko Teraoka-Nishitani, Akane Yamagata, Takahiro Tanaka, Marika Sasaki, Natsuki Yasuda, Makiko Oda, Tatsuji Okano, Kazuhiro Yamahira …

TOXICOLOGY, 382 16-23, May, 2017 Peer-reviewed
Fipronil, an insecticide, acts as an anti-estrogen via the concomitant down-regulation of ERα and PES1

Okazaki Hiroyuki, Kohro-Ikeda Eriko, Takeda Shuso, Ishii Hiroyuki, Furuta Erika, Matsuo Saki, Matsumoto Masaya, Takiguchi Masufumi, Aramaki Hironori

Fundamental Toxicological Sciences, 3(1) 33-37, 2016
Preventive effects of metallothionein against DNA and lipid metabolic damages in dyslipidemic mice under repeated mild stress

Minoru Higashimoto, Naohiro Isoyama, Satoshi Ishibashi, Naoko Ogawa, Masufumi Takiguchi, Shinya Suzuki, Yoshinari Ohnishi, Masao Sato

Journal of Medical Investigation, 60(3-4) 240-248, 2013 Peer-reviewed
Novel pathway of metabolic activation of bisphenol a-related compounds for estrogenic activity

Katsuhiro Okuda, Tomoko Fukuuchi, Masufumi Takiguchi, Shin'ichi Yoshihara

Drug Metabolism and Disposition, 39(9) 1696-1703, Sep, 2011 Peer-reviewed
In vivo estrogenic potential of 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, an active metabolite of bisphenol A, in uterus of ovariectomized rat

Katsuhiro Okuda, Masufumi Takiguchi, Shin'ichi Yoshihara

TOXICOLOGY LETTERS, 197(1) 7-11, Aug, 2010 Peer-reviewed

Misc.

PPARα-mediated regulation mechanisms of fatty acid 2-hydroxylase (FA2H) expression in MDA-MB-231 cells

平尾雅代, 境絃樹, 古賀貴之, 田中満崇, 杉原成美, 瀧口益史, 竹田修三

日本薬学会年会要旨集(Web), 142nd, 2022
Cannabidiolic acid mediated-down-regulation of COX-2 expression through the abrogation of PPARβ/δ signaling

平尾雅代, 古賀貴之, 境絃樹, 瀧口益史, 戸田晶久, 杉原成美, 竹田修三

Journal of Toxicological Sciences, 46(Supplement), 2021
Perfluorooctanoic acid stimulates breast cancer cell migration depending on the PPARα-FA2H axis

境絃樹, 平尾雅代, 古賀貴之, 瀧口益史, 杉原成美, 竹田修三

衛生薬学・環境トキシコロジー講演要旨集, 2021, 2021
Repeated exposure to MBP, an active metabolite of bisphenol A, stimulates breast cancer cell proliferation through ERβ activation

平尾雅代, 境絃樹, 田中満崇, 杉原成美, 瀧口益史, 竹田修三

衛生薬学・環境トキシコロジー講演要旨集, 2021, 2021
Cannabidiolic acid down-regulates COX-2 expression through abrogating PPARβ/δ function

平尾雅代, 古賀貴之, 境絃樹, 境絃樹, 瀧口益史, 戸田晶久, 杉原成美, 竹田修三, 竹田修三

日本薬学会年会要旨集(Web), 141st, 2021
Δ9-Tetrahydrocannabinolによるfatty acid 2-hydroxylase(FA2H)の発現誘導 PPARαとPPARβ/δの相互作用に注目した解析

平尾雅代, 竹田修三, 杉原成美, 瀧口益史, 大原正裕

The Journal of Toxicological Sciences, 45(Suppl.) S165-S165, Jun, 2020
Cannabidiolic acid down-regulation of COX-2 expression through abrogation of PPARβ/δ function

平尾雅代, 竹田修三, 古賀貴之, 瀧口益史, 戸田晶久

日本薬学会年会要旨集(CD-ROM), 140th, 2020
Stemonamine derivatives stimulate anti-proliferative effects mediated by trichostatin A on ERα-negative human breast cancer cells

平尾雅代, 竹田修三, 岩田隆幸, 富山泰至, 藤田聡, 瀧口益史, 新藤充

日本薬学会年会要旨集(CD-ROM), 140th, 2020
ビスフェノールAの活性代謝物(MBP)によるERβの活性化を介したER陽性乳がん細胞の増殖促進

平尾雅代, 竹田修三, 奥田勝博, 瀧口益史, 吉原新一

The Journal of Toxicological Sciences, 44(Suppl.) S237-S237, Jun, 2019
カドミウムによるがん細胞浸潤の亢進アポリポプロテインEの発現はエピジェネティクス修飾を介して調節される

平尾雅代, 竹田修三, 小林隆信, 喜納克仁, 宮澤宏, 瀧口益史

The Journal of Toxicological Sciences, 43(Suppl.) S222-S222, Jun, 2018
乳がん細胞migrationの正の調節因子としてのfatty acid 2-hydroxylase(FA2H)の可能性

鈴木雅代, 竹田修三, 岡島隼輔, 三好弘子, 渡辺和人, 瀧口益史, 荒牧弘範

日本薬学会年会要旨集, 138年会(3) 217-217, Mar, 2018
カドミウムによる細胞浸潤能の亢進における標的遺伝子としてのアポリポプロテインEの確立

鈴木雅代, 竹田修三, 中村優太, 瀧口益史

The Journal of Toxicological Sciences, 42(Suppl.) S213-S213, Jun, 2017
繊維型大麻草主成分cannabidiolic acid(CBDA)によるアクチンストレスファイバー形成の調節とその意義

竹田修三, 鈴木雅代, 岡崎裕之, 渡辺和人, 瀧口益史, 荒牧弘範

The Journal of Toxicological Sciences, 42(Suppl.) S340-S340, Jun, 2017
ビスフェノールAFによるエストロゲンシグナルの修飾アゴニスト・アンタゴニスト作用

岡崎裕之, 高露恵理子[池田], 水之江来夢, 徳安美紀, 石井宏幸, 垣添和弘, 谷口彩, 姫野太一, 竹田修三, 滝口益史 …

日本薬学会年会要旨集, 136年会(3) 242-242, Mar, 2016
カドミウムによる悪性形質転換:細胞浸潤亢進メカニズムの解析

竹田修三, 安田菜月, 西谷典子, WAALKES Michael P, 瀧口益史

日本薬学会年会要旨集(CD-ROM), 135th(3) 227-227, 2015
種々の重金属が細胞内MMP2活性に与える影響

西谷典子, 竹田修三, 瀧口益史

日本薬学会年会要旨集(CD-ROM), 134th(3) 213-213, 2014
Tissue-dependent preventive effect of metallothionein against DNA damage in dyslipidemic mice under repeated stresses of fasting or restraint

Minoru Higashimoto, Naohiro Isoyama, Satoshi Ishibashi, Masahisa Inoue, Masufumi Takiguchi, Shinya Suzuki, Yoshinari Ohnishi, Masao Sato

LIFE SCIENCES, 84(17-18) 569-575, Apr, 2009 Peer-reviewed
カドミウムの胎盤毒性-環境ホルモン作用を中心に

瀧口益史, 吉原新一

臨床検査, 51(13) 1719-1723, 2007 Lead authorCorresponding author
Involvement of oxidative stress in the synthesis of metallothionein induced by mitochondrial inhibitors

Naoki Futakawa, Masuo Kondoh, Satoshi Ueda, Minoru Higashimoto, Masufumi Takiguchi, Shinya Suzuki, Masao Sato

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 29(10) 2016-2020, Oct, 2006 Peer-reviewed
A norbergenin derivative inhibits neuronal cell damage induced by tunicamycin

Shinya Suzuki, Yui Okuse, Masafumi Kawase, Masufumi Takiguchi, Yoshiyasu Fukuyama, Hironobu Takahashi, Masao Sato

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 29(7) 1335-1338, Jul, 2006 Peer-reviewed

Books and Other Publications

予防薬学としての衛生薬学 : 健康と環境

(Role: Contributor)

廣川書店, Jun, 2022 (ISBN: 9784567472036)
コンパス衛生薬学 : 健康と環境

(Role: Contributor)

南江堂, Mar, 2020 (ISBN: 9784524403714)
食品の安全

(Role: Contributor)

南江堂, Dec, 2018 (ISBN: 9784524245321)
予防薬学としての衛生薬学 : 健康と環境

(Role: Contributor)

廣川書店, Mar, 2016 (ISBN: 9784567472029)
衛生薬学 : 健康と環境

日本薬学会 (Role: Contributor)

東京化学同人, Feb, 2016 (ISBN: 9784807917112)
健康と環境の科学

(Role: Contributor)

講談社, Mar, 2014 (ISBN: 9784061552340)
予防薬学としての衛生化学-健康と環境-

廣川書店, 2009 (ISBN: 9784567472005)

Professional Memberships

Research Projects

Anti-carcinogenic effects of zinc by induction of apoptosis and inhibition of DNA methylation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Oct, 2010 - Mar, 2014

TAKIGUCHI Masufumi
The role of DNA methylation in cadmium-induced anti-carcinogenesis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2009

TAKIGUCHI Masufumi
重金属やストレス環境で誘導されるメタロチオネインのガン悪性化機構における役割

科学研究費助成事業, 若手研究(B), 日本学術振興会, 2005 - 2006

瀧口益史
環境汚染物質カドミウムのDNAメチル化異常による発ガン機構

科学研究費助成事業, 若手研究(B), 日本学術振興会, 2003 - 2004

瀧口益史
ストレスと生体内重金属
メタロチオネインとガン化機構の関係解析
カドミウムの発ガン及び抗ガン作用とDNAメチル化の関係解析
金属の生理機能解析
Role of DNA methylation in cadmium carcinogenesis and anti-carcinogenesis
Study on the biological function of metals

Profile Information

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Awards

Papers

Misc.

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