2000年
O-6-(fluorobenzyl)guanine and chloroethylnitrosourea in xenografted rat brain tumor in vivo
ACTA ONCOLOGICA
- ,
- ,
- ,
- 巻
- 39
- 号
- 1
- 開始ページ
- 89
- 終了ページ
- 95
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1080/028418600431030
- 出版者・発行元
- SCANDINAVIAN UNIVERSITY PRESS
O-6-methylguanine-DNA methyltransferase (MGMT), one of the DNA repair enzymes; potently repairs DNA damage induced by chloroethylnitrosoureas (CENUs). Depletion of MGMT activity after treatment with MGMT inhibitors increases the sensitivity of tumor cells to CENUs. We tested the effect of O-6-(4-, 3- and 2-fluorobenzyl)guanines (4F, 3F and 2F, respectively), three newly synthesized MGMT inhibitors, on 1-(4-amino-2-methyl-5-pyrimidinyl)methy-3-(2-chloroethyl)-3-nitrosoureahydrochloride (ACNU) therapy in C6 tumor xenografts. Treatment with 4F + ACNU and 3F + ACNU significantly decreased tumor volume and extended the delay of growth in comparison to untreated mice (control group, p < 0.05). Both groups showed significantly lower proliferating indices than the control group (p < 0.05) 12 h after treatment. In contrast, 2F did not enhance the ACNU anti-tumor effect. These results indicate that O-6-(4- and 3-fluorobenzyl)guanines as well as O-6-benzylguanines enhance the effect of ACNU on the growth of C6 tumor xenografts in vivo.
- リンク情報
-
- DOI
- https://doi.org/10.1080/028418600431030
- CiNii Articles
- http://ci.nii.ac.jp/naid/10026995758
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/10752660
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000085950100014&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1080/028418600431030
- ISSN : 0284-186X
- CiNii Articles ID : 10026995758
- PubMed ID : 10752660
- Web of Science ID : WOS:000085950100014