WATANABE Eizo

J-GLOBAL         Last updated: Oct 28, 2018 at 17:43
 
Avatar
Name
WATANABE Eizo
Affiliation
Chiba University
Section
Department of General Medical Science
Job title
Professor
Degree
MD, PhD
Other affiliation
Eastern Chiba Medical Center
Research funding number
40375639
ORCID ID
0000-0001-6731-909X

Profile

Main Research Topics
・Autophagy in sepsis pathophysiology
・Genetic association in critical care illnesses
・Pathophysiology of DIC and TMA in relation to complement regulation
・Immunotherapy for immunosuppressive sepsis
・Artificial organ supports(ex,mechanical ventilation,blood purification,ECMO support, etc.)

Research Areas

 
 

Academic & Professional Experience

 
Apr 2017
 - 
Today
Professor, Department of General Medical Science, Chiba University Graduate School of Medicine
 
Apr 2009
 - 
Mar 2017
Associate Professor, Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University
 
Apr 2000
 - 
Mar 2002
Graduate Student in Department of Developmental Genetics, Graduate School of Medicine, Chiba University
 
Apr 2006
 - 
Jun 2008
Research Assistant in Department of Surgery, Washington University School of Medicine
 
Jul 2008
 - 
Mar 2009
Postdoctoral Research Associate in Department of Anesthesiology, Washington University School of Medicine
 

Education

 
 
 - 
2004
Graduate School, Division of Medicine, Chiba University
 
 
 - 
1997
Faculty of Medicine, Chiba University
 

Committee Memberships

 
Jan 2017
 - 
Today
Shock Society  Editorial Board Member
 
Oct 2016
 - 
Today
Frontiers in Medicine  Editorial Board Member
 
2017
 - 
Today
Japanese Association for Acute Medicine  Associate Editor of Acute Medicine & Surgery
 
2014
 - 
2017
Society of Critical Care Medicine  Advanced Knowledge Assessment in Adult Critical Care (AKAACC) Committee
 
2010
   
 
Japanese Association for Acute Medicine  Councilor
 
2010
   
 
Japanese Society for Abdominal Emergency Medicine  Councilor
 
2011
   
 
Japan Shock Society  Councilor
 
2011
   
 
Japanese Society for Surgical Metabolism and Nutrition  Councilor
 

Awards & Honors

 
2015
Programmed Cell Death in Sepsis -Determining whether it is a friend or foe-, The Chiba Medical Society Award (2015), The Chiba Medical Society
 
Mar 2012
The 48th Annual Congress of Japanese Society for Abdominal Emergency Medicine Presidential Award, Japanese Society for Abdominal Emergency Medicine
 
2011
ZENKYOREN Traffic Accident Research Foundation
 
2010
8th World Congress on Trauma, Shock, Inflammation and Sepsis - TSIS 2010: Young Investigator’s Arthur E. Baue Award
 
2010
The 47nd Annual Meeting Japan Society for Surgical Metabolism and Nutrition: Scientific Paper Award
 
2009
The Shock Society’s 32nd Annual Conference on Shock: Young Investigators Travel Award
 
2009
The 24th Japan Shock Society: The Best Presentation Award
 
2008
NIH 6th Symposium on the Functional Genomics of Critical Care Illness & Injury: Peer Review Poster Award
 
2008
The Society of Critical Care Medicine’s 37th Critical Care Congress: Sepsis Specialty Award
 
2006
The 43rd Annual Meeting Japan Society for Surgical Metabolism and Nutrition: Scientific Paper Award
 

Published Papers

 
Oami T, Watanabe E, Hatano M, Teratake Y, Fujimura L, Sakamoto A, Ito C, Toshimori K, Swanson PE, Oda S
Shock (Augusta, Ga.)   50(4) 427-434   Oct 2018   [Refereed]
Watanabe E, Thampy LK, Hotchkiss RS
Acute medicine & surgery   5(4) 309-315   Oct 2018   [Refereed]
Vincent JL, Castro P, Hunt BJ, Jörres A, Praga M, Rojas-Suarez J, Watanabe E
Critical care (London, England)   22(1) 158   Jun 2018   [Refereed]
Sunahara S, Watanabe E, Hatano M, Swanson PE, Oami T, Fujimura L, Teratake Y, Shimazui T, Lee C, Oda S
Scientific reports   8(1) 1050   Jan 2018   [Refereed]
Hayakawa M, Kushimoto S, Watanabe E, Goto K, Suzuki Y, Kotani T, Kiguchi T, Yatabe T, Tagawa J, Komatsu F, Gando S
Thrombosis and haemostasis   117(5) 851-859   May 2017   [Refereed]
Oami T, Watanabe E, Hatano M, Sunahara S, Fujimura L, Sakamoto A, Ito C, Toshimori K, Oda S
Critical care medicine   45(1) e77-e85   Jan 2017   [Refereed]
Watanabe E, Yamazaki S, Setoguchi D, Sadahiro T, Tateishi Y, Suzuki T, Ishii I, Oda S
Frontiers in medicine   4 15   2017   [Refereed]
Oami T, Hattori N, Matsumura Y, Watanabe E, Abe R, Oshima T, Takahashi W, Yamazaki S, Suzuki T, Oda S
Frontiers in medicine   4 70   2017   [Refereed]
Tomita K, Watanabe E, Sadahiro T, Tateishi Y, Shinozaki K, Rikihisa N, Oda S
Acute medicine & surgery   3(3) 279-282   Jul 2016   [Refereed]
Omura T, Watanabe E, Otsuka Y, Yoshida Y, Kato H, Nangaku M, Miyata T, Oda S
Medicine   95(27) e4104   Jul 2016   [Refereed]
Watanabe E, Zehnbauer BA, Oda S, Sato Y, Hirasawa H, Buchman TG
Cytokine   60(1) 249-256   Jun 2012   [Refereed]
Nakamura M, Oda S, Sadahiro T, Watanabe E, Abe R, Nakada TA, Morita Y, Hirasawa H
Critical care (London, England)   16 R58   Apr 2012   [Refereed]
Sadahiro T, Oda S, Nakamura M, Hirayama Y, Watanabe E, Tateishi Y, Shinozaki K
General thoracic and cardiovascular surgery   60 192-201   Apr 2012   [Refereed]
Setoguchi D, Yatsuki H, Sadahiro T, Nakamura M, Hirayama Y, Watanabe E, Tateishi Y, Oda S
Cytokine   57(2) 238-244   Feb 2012   [Refereed]
Matsumura Y, Oda S, Sadahiro T, Nakamura M, Hirayama Y, Watanabe E, Abe R, Nakada TA, Tateishi Y, Oshima T, Shinozaki K, Hirasawa H
The International journal of artificial organs   35(1) 3-14   Jan 2012   [Refereed]
Setoguchi D, Nakamura M, Yatsuki H, Watanabe E, Tateishi Y, Kuwaki T, Oda S
International immunopharmacology   11(12) 2073-2078   Dec 2011   [Refereed]
Takai N, Oda S, Sadahiro T, Nakamura M, Watanabe E, Tateishi Y, Shinozaki K, Nomura F, Mamada K
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society   28 302-307   Jun 2011   [Refereed]
Shinozaki K, Oda S, Sadahiro T, Nakamura M, Hirayama Y, Watanabe E, Tateishi Y, Nakanishi K, Kitamura N, Sato Y, Hirasawa H
Resuscitation   82(4) 404-409   Apr 2011   [Refereed]
Shimada T, Oda S, Sadahiro T, Nakamura M, Hirayama Y, Watanabe E, Abe R, Nakada TA, Tateishi Y, Otani S, Hirasawa H, Tokuhisa T, Uno H
Cytokine   54(1) 79-84   Apr 2011   [Refereed]
Hirayama Y, Oda S, Wakabayashi K, Sadahiro T, Nakamura M, Watanabe E, Tateishi Y
Blood purification   31 18-25   2011   [Refereed]
Unsinger J, McGlynn M, Kasten KR, Hoekzema AS, Watanabe E, Muenzer JT, McDonough JS, Tschoep J, Ferguson TA, McDunn JE, Morre M, Hildeman DA, Caldwell CC, Hotchkiss RS
Journal of immunology (Baltimore, Md. : 1950)   184(7) 3768-3779   Apr 2010   [Refereed]
Watanabe E, Buchman TG, Hirasawa H, Zehnbauer BA
Critical care medicine   38(1) 181-193   Jan 2010   [Refereed]
Bradfute SB, Swanson PE, Smith MA, Watanabe E, McDunn JE, Hotchkiss RS, Bavari S
Journal of immunology (Baltimore, Md. : 1950)   184(1) 327-335   Jan 2010   [Refereed]
Oda S, Sadahiro T, Hirayama Y, Nakamura M, Watanabe E, Tateishi Y, Hirasawa H
Contributions to nephrology   166 47-53   2010   [Refereed]
Nakamura M, Oda S, Sadahiro T, Hirayama Y, Watanabe E, Tateishi Y, Nakada TA, Hirasawa H
Contributions to nephrology   166 73-82   2010   [Refereed]
Otani S, Oda S, Sadahiro T, Nakamura M, Watanabe E, Nakada TA, Abe R, Tokuhisa T, Hirasawa H
Clinical biochemistry   42 1387-1393   Sep 2009   [Refereed]
Brahmamdam P, Watanabe E, Unsinger J, Chang KC, Schierding W, Hoekzema AS, Zhou TT, McDonough JS, Holemon H, Heidel JD, Coopersmith CM, McDunn JE, Hotchkiss RS
Shock (Augusta, Ga.)   32 131-139   Aug 2009   [Refereed]
Watanabe E, Muenzer JT, Hawkins WG, Davis CG, Dixon DJ, McDunn JE, Brackett DJ, Lerner MR, Swanson PE, Hotchkiss RS
Laboratory investigation; a journal of technical methods and pathology   89(5) 549-561   May 2009   [Refereed]
Abe R, Hirasawa H, Oda S, Sadahiro T, Nakamura M, Watanabe E, Nakada TA, Hatano M, Tokuhisa T
The Journal of surgical research   147 1-8   Jun 2008   [Refereed]
Nakada TA, Hirasawa H, Oda S, Shiga H, Matsuda K, Nakamura M, Watanabe E, Abe R, Hatano M, Tokuhisa T
The Journal of surgical research   129 322-328   Dec 2005   [Refereed]
Watanabe E, Hirasawa H, Oda S, Shiga H, Matsuda K, Nakamura M, Abe R, Nakada T
The Journal of trauma   59 1181-9; discussion 1189   Nov 2005   [Refereed]
Oda S, Hirasawa H, Shiga H, Matsuda K, Nakamura M, Watanabe E, Moriguchi T
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy   9(4) 355-361   Aug 2005   [Refereed]
Watanabe E, Hirasawa H, Oda S, Matsuda K, Hatano M, Tokuhisa T
Critical care medicine   33 89-97; discussion 242   Jan 2005   [Refereed]
Nakanishi K, Hirasawa H, Oda S, Shiga H, Matsuda K, Nakamura M, Hirano T, Hirayama Y, Moriguchi T, Watanabe E, Nitta M
Blood purification   23 113-118   2005   [Refereed]
[Basic concept and definition of SIRS and sepsis--present consideration and future perspectives].
Hirasawa H, Oda S, Matsuda K, Watanabe E
Nihon rinsho. Japanese journal of clinical medicine   62 2177-2183   Dec 2004   [Refereed]
[New anti-cytokine strategy against patients with hypercytokinemia stratified by cytokine-related genetic polymorphisms].
Watanabe E, Hirasawa H, Matsuda K
Nihon rinsho. Japanese journal of clinical medicine   62 2317-2322   Dec 2004   [Refereed]
Hirayama Y, Hirasawa H, Oda S, Shiga H, Nakanishi K, Matsuda K, Nakamura M, Hirano T, Moriguchi T, Watanabe E, Nitta M, Abe R, Nakada T
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy   7 475-482   Oct 2003   [Refereed]
Moriguchi T, Hirasawa H, Oda S, Shiga H, Nakanishi K, Matsuda K, Nakamura M, Yokohari K, Hirano T, Hirayama Y, Watanabe E
Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis   6 221-224   Jun 2002   [Refereed]

Misc

 
Eizo Watanabe, Hiroyuki Hirasawa, Shigeto Oda, Kenichi Matsuda, Masahiko Hatano, Takeshi Tokuhisa
Critical Care Medicine   33(1) 89-97   2005
Eizo Watanabe, Hiroyuki Hirasawa, Shigeto Oda, Hidetoshi Shiga, Kenichi Matsuda, Masataka Nakamura, Ryuzo Abe, Takaaki Nakada
The Journal of Trauma   59(5) 1181-1189   2005
Eizo Watanabe, Jared T. Muenzer, William G. Hawkins, Chris G. Davis, David J. Dixon, Jonathan E. McDunn, Daniel J. Brackett, Megan R. Lerner, Paul E. Swanson, Richard S. Hotchkiss
Laboratory Investigation   89(5) 549-561   2009
Eizo Watanabe, Barbara A Zehnbauer, Clifford S Deutschman
Critical Care Medicine   37(1) 357-360   2009
Eizo Watanabe, Timothy G Buchman, Hiroyuki Hirasawa, Barbara A Zehnbauer
Critical Care Medicine   38(1) 181-193   2010

Books etc

 
Internal Congress Series No.1225 “Cellular, Molecular and Genetic Aspects of the Biological Response to Planned and Unplanned Injuries.”
WATANABE Eizo (Part:Joint Work, Clinical aspect of hypercytokinemia-induced pathophysiology in critical care.)
Elsevier Science   2003   

Conference Activities & Talks

 
Autophagy mechanism attenuates hepatic cellular dysfunction in a murine sepsis model.
WATANABE Eizo
The Shock Society’s 41st Annual Conference on Shock   Jun 2018   
Gene expression profiles in sepsis patients with leukocytopenia.
WATANABE Eizo
The Shock Society’s 40th Annual Conference on Shock   Jun 2017   
Sequential gene expression profiles in septic patients.
WATANABE Eizo
The 46th Critical Care Congress   Jan 2017   
A THBD promoter polymorphism influences outcome of severe sepsis through the gene transcriptional regulation.
WATANABE Eizo
The Shock Society’s 39th Annual Conference on Shock   Jun 2016   
Genetic polymorphisms and severe sepsis. - A multi-center study in the Japanese ICU population
WATANABE Eizo
The Shock Society’s 38th Annual Conference on Shock   Jun 2015   
Autophagy-related ATG16L1 polymorphism was not associated with susceptibility to nor outcome of severe sepsis in the Japanese intensive care units.
WATANABE Eizo
The Shock Society’s 37th Annual Conference on Shock   Jun 2014   
An IRGM polymorphism (rs10065172) is associated with mortality of severe sepsis through the down-regulation of IRGM gene expression with LPS challenge.
WATANABE Eizo
The 11th World Federation of Societies of Intensive and Critical Care Medicine Congress   Aug 2013   
Comparative pharmacokinetics of hig- and low-dose recombinant human thrombomodulin in patients with septic disseminated intravascular coagulation during continuous hemodiafiltration.
WATANABE Eizo
The Shock Society’s 36th Annual Conference on Shock   Jun 2013   
Tumor necrosis factor -308 polymorphism is associated with mortality and ventilator free days in 1057 Caucasian patients
WATANABE Eizo
35th Annual Conference on Shock   Jun 2012   
Autophagy-Related Cellular Injury and Inflammation in Sepsis. [Invited]
Eizo Watanabe
34th Annual Conference on Shock, Plenary Symposium I   Jun 2011   
FFECT OF HERITABLE AND AQUIRED CONDITIONS ON MORTALITY OF 854 US PATIENTS WITH SEVERE SEPSIS.
33rd Annual Conference on Shock   2010   
Relationship between autophagy and cytokine productions as well as hepatocyte vacuolization in patients with severe sepsis.
8th World Congress on Trauma, Shock, Inflammation and Sepsis - TSIS 2010   2010   
EFFECT OF HERITABLE AND AQUIRED CONDITIONS ON MORTALITY OF PATIENTS WITH SEVERE SEPSIS
The 10th Joint Scientific Congress of KSCCM and JSICM   2009   
SEPSIS-INDUCED SUPPRESSION OF TH1 PHENOTYPE IS NOT DUE TO THE RISE IN TH2 CELLS.
32nd Annual Conference on Shock   2009   
Sepsis Induces Extensive Autophagic Vacuolization in Hepatocytes – a clinical and laboratory based study.
The 5th Washington University Annual Postdoc Scientific Symposium   2009   
Heritable and acquired conditions predispose to severe sepsis.
NIH 6th Symposium on the Functional Genomics of Critical Illness and Injury   2008   
Sepsis induces autophagy in liver.
31st Annual Conference on Shock   2008   
Tumor necrosis factor-beta polymorphism is associated with predisposition to severe sepsis and longer mechanical ventilation.
37th Critical Care Congress   2008   
Relationship between heritable factors and acute physiology with respect to the predisposition to sepsis.
30th Annual Conference on Shock   2007   
Cytokine-related genotypic differences in the peak interleukin-6 blood level of the patients with SIRS and septic complications.
American Association for the Surgery of Trauma 63rd Meeting and Japanese Association for Acute Medicine   2004   
Tumor necrosis factor-alpha promoter polymorphism in critically ill patients with extremely high interleukin-6 blood level.
32nd Critical Care Congress   2003   
TUMOR NECROSIS FACTOR (TNF) -α PROMOTER POLYMORPHISM IN CRITICALLY ILL PATIENTS WITH EXTREMELY HIGH INTERLEUKIN (IL) - 6 BLOOD LEVEL
19th Kumamoto Medical Bioscience Symposium   2002   
Relation between tumor necrosis factor-alpha promoter polymorphism and extremely high interleukin-6 blood level in critically ill patients.
The 25th Annual Meeting of the Molecular Biology Society of Japan   2002   

Research Grants & Projects

 
The Japanese Association for Complement Research: Research Grant from the Japanese Association for Complement Research
Project Year: 2018 - 2020    Investigator(s): WATANABE Eizo
Association between septic multiple organ failure and autophagic cell death
Grant-in-Aid for Scientific Research
Project Year: 2010   
Autophagy is the regulated process cells use to recycle non-essential, redundant, or inefficient components and is an adaptive response during times of stress. In addition to its role in enabling the cell to gain vital nutrients in times of stres...
Functional Genomics in Critical Care (Sepsis Genomics)
0086 (Japanese Only)
Project Year: 2001   
Sepsis remains a critical and costly public health problem. Recently, an evidence-based system for assessing quality of evidence of sepsis diagnosis and strength of recommendations for treatment has been used to develop an aggressive strategy for ...