2009年
EFFECT OF CHARCOAL HEMOPERFUSION FOR REMOVAL OF PLASMA METHOTREXATE IN A PATIENT WITH ACUTE RENAL FAILURE
PEDIATRIC HEMATOLOGY AND ONCOLOGY
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- 巻
- 26
- 号
- 7
- 開始ページ
- 520
- 終了ページ
- 525
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1080/08880010902976023
- 出版者・発行元
- TAYLOR & FRANCIS INC
Strategies effective for accelerating methotrexate removal in delayed methotrexate excretion have not been universally accepted. The authors report a case of a 12-year-old girl with osteosarcoma who developed acute renal failure immediately after the first administration of high-dose methotrexate. Plasma methotrexate was effectively removed with repeated charcoal hemoperfusion in addition to plasma exchange and leucovorin rescue. Charcoal hemoperfusion was most effective for reducing plasma methotrexate with approximately 50% of methotrexate being reduced during each of the procedures. No rebound increase in MTX levels was observed. The patient received further therapy with other cancer drugs and has been well for 3.5 years.
- リンク情報
- ID情報
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- DOI : 10.1080/08880010902976023
- ISSN : 0888-0018
- PubMed ID : 19863208
- Web of Science ID : WOS:000270288500006