2003年
Alveolar soft part sarcoma in Japan: Multi-institutional study of 57 patients from the Japanese musculoskeletal oncology group
ONCOLOGY
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- 巻
- 65
- 号
- 1
- 開始ページ
- 7
- 終了ページ
- 13
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1159/000071199
- 出版者・発行元
- KARGER
Objective: The clinical features and the management of alveolar soft part sarcoma (ASPS) are not well known. The efficacy of chemotherapy for soft tissue sarcoma, including high-dose ifosfamide and cisplatin, has not been established yet. Some reports suggest ASPS may occur primarily in bone. Methods: We report on a series of 57 patients with ASPS over 20 years. Their ages ranged from 7 to 75 years (mean 25). Results:There were 37 females and 20 males. Thirteen lesions (23%) showed bone involvement at the primary site, and 6 of them were diagnosed as bone tumors at presentation. Thirty-seven patients had distant metastases at presentation. Tumor size, bone involvement at the primary site and the presence of metastases at presentation were prognostic indicators (p < 0.05). Marginal exicision with radiotherapy or wide excision without radiotherapy achieved good local control. Chemotherapy was performed in 47 patients with different regimens. Two patients treated with intraarterial chemotherapy regimens responded partially, but intravenous chemotherapy with high-dose ifosfamide or cisplatin failed. Conclusions: ASPS can present primarily as a bone tumor. No advantage of chemotherapy with high-dose ifosfamide or cisplatin could be demonstrated. Copyright (C) 2003 S. Karger AG, Basel.
- リンク情報
- ID情報
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- DOI : 10.1159/000071199
- ISSN : 0030-2414
- PubMed ID : 12837977
- Web of Science ID : WOS:000184155500002