2008年8月
Postischemic mild hypothermia alleviates hearing loss because of transient ischemia
NEUROREPORT
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- 巻
- 19
- 号
- 13
- 開始ページ
- 1325
- 終了ページ
- 1328
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1097/WNR.0b013e32830b5f73
- 出版者・発行元
- LIPPINCOTT WILLIAMS & WILKINS
The effect of postischemic mild hypothermia on the inner ear has not been clarified. In this study, we investigated whether hypothermia after transient ischemia could prevent cochlear damage and its therapeutic time window. Mongolian gerbils were divided into six groups: a sham-operation group, a normothermia group, and four hypothermia groups in which hypothermia was induced 1-7, 1-4, 36, and 6-9 h after reperfusion. Animals subjected to postischemic mild hypothermia within 3 h after reperfusion had attenuated hearing loss and inner hair cell loss. The protective effect was greater when hypothermia was induced earlier and had a longer duration. This implies that mild hypothermia after ischemia could have therapeutic effects for inner ear ischemic damage. NeuroReport 19:1325-1328 (c) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
- リンク情報
- ID情報
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- DOI : 10.1097/WNR.0b013e32830b5f73
- ISSN : 0959-4965
- Web of Science ID : WOS:000258767700016