論文

査読有り
2009年5月

Urinary calreticulin in the diagnosis of bladder urothelial carcinoma

INTERNATIONAL JOURNAL OF UROLOGY
  • Susumu Kageyama
  • ,
  • Takahiro Isono
  • ,
  • Shinjiro Matsuda
  • ,
  • Yoshihiro Ushio
  • ,
  • Shinji Satomura
  • ,
  • Akito Terai
  • ,
  • Yoichi Arai
  • ,
  • Mutsushi Kawakita
  • ,
  • Yusaku Okada
  • ,
  • Tatsuhiro Yoshiki

16
5
開始ページ
481
終了ページ
486
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/j.1442-2042.2009.02287.x
出版者・発行元
WILEY-BLACKWELL PUBLISHING, INC

To evaluate the potential suitability of calreticulin (CRT) as a urinary marker for bladder cancer.
Urine specimens were collected from patients with histologically confirmed bladder urothelial carcinoma (Group 1; n = 109), urological patients without urothelial carcinoma (Group 2; n = 60), and non-urological patients (Group 3; n = 40). We developed an enzyme-linked immunosorbent assay (ELISA) procedure using commercially available anti-CRT mono/polyclonal antibodies, and then measured the concentration of urinary CRT.
Urinary CRT concentration of group 1 was significantly higher than group 2 and 3 (Mann-Whitney U-test, P < 0.001). Groups 2 and 3 were joined together and considered as a non-bladder cancer group (n = 100), and a cutoff value (2.85 ng/mL) was determined using receiver operating characteristic (ROC) analysis. The sensitivity, specificity, and the area under the curve were 67.9%, 80.0%, and 0.742, respectively. The overall sensitivity of voided urine cytology (VUC) was 39.0% (n = 105), and the sensitivity of urinary CRT was significantly superior to VUC (McNemar test, P < 0.001). Higher sensitivity was observed especially in Ta, G1-2, and <= 3 cm tumors.
Urinary CRT may be useful for diagnosis of bladder urothelial cancer. However, given that its specificity is relatively low, further evaluation in larger series is needed to define its clinical usefulness.

Web of Science ® 被引用回数 : 30

リンク情報
DOI
https://doi.org/10.1111/j.1442-2042.2009.02287.x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19389084
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000265709200009&DestApp=WOS_CPL

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