論文

査読有り
2015年

A GGCT fluorogenic probe: design, synthesis and application to cancer-related cells

ORGANIC & BIOMOLECULAR CHEMISTRY
  • Taku Yoshiya
  • ,
  • Hiromi Ii
  • ,
  • Shugo Tsuda
  • ,
  • Susumu Kageyama
  • ,
  • Tatsuhiro Yoshiki
  • ,
  • Yuji Nishiuchi

13
11
開始ページ
3182
終了ページ
3185
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1039/c5ob00086f
出版者・発行元
ROYAL SOC CHEMISTRY

Cancer-related gamma-glutamyl cyclotransferase (GGCT) specifically converts.-glutamyl amino acids (gamma-Glu-Xaa) into pyroglutamate and the corresponding amino acids (Xaa). Here we report a novel GGCT fluorogenic probe "LISA-101" containing a masked O-acylated fluorophore "resorufin" on the side chain of the P-1' amino acid (Xaa). Upon GGCT treatment, the P-1' amino acid was liberated and spontaneously released the intact fluorophore. Thus, the fluorescence was regained. LISA-101 will expand the strategies for cancer studies.

Web of Science ® 被引用回数 : 6

リンク情報
DOI
https://doi.org/10.1039/c5ob00086f
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25651484
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000351062700002&DestApp=WOS_CPL

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