論文

査読有り
2015年

Gamma-Glutamylcyclotransferase: A Novel Target Molecule for Cancer Diagnosis and Treatment

BIOMED RESEARCH INTERNATIONAL
  • Susumu Kageyama
  • ,
  • Eiki Hanada
  • ,
  • Hiromi Ii
  • ,
  • Keiji Tomita
  • ,
  • Tatsuhiro Yoshiki
  • ,
  • Akihiro Kawauchi

2015
開始ページ
in press
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1155/2015/345219
出版者・発行元
HINDAWI PUBLISHING CORPORATION

Gamma-glutamylcyclotransferase (GGCT) is one of the major enzymes involved in glutathione metabolism. However, its gene locus was unknown for many years. Recently, the gene for GGCT was found to be identical to C7orf24, which is registered as a hypothetical protein. Orthologs have been found in bacteria, plants, and nematodes as well as higher organisms, and the GGCT gene is highly preserved among a wide range of species. GGCT (C7orf24) was also reported as an upregulated protein in various cancers. Although the function of GGCT in cancer cells has not been determined, the following important activities have been reported: (1) high expression in various cancer tissues and cancer cell lines, (2) low expression in normal tissues, (3) inhibition of cancer cell proliferation via anti-GGCT RNAi, (4) inhibition of cancer cell invasion and migration via anti-GGCT RNAi, (5) an epigenetic transcriptional regulation in cancer cells, and (6) an antitumor effect in cancer-bearing xenograft mice. Therefore, GGCT is promising as a diagnostic marker and a therapeutic target for various cancers. This review summarizes these interesting findings.

Web of Science ® 被引用回数 : 12

リンク情報
DOI
https://doi.org/10.1155/2015/345219
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26339607
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000359581800001&DestApp=WOS_CPL

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