論文

査読有り
2016年

Hydroxyl-HIF2-alpha is potential therapeutic target for renal cell carcinomas

AMERICAN JOURNAL OF CANCER RESEARCH
  • Takahiro Isono
  • ,
  • Tokuhiro Chano
  • ,
  • Tetsuya Yoshida
  • ,
  • Susumu Kageyama
  • ,
  • Akihiro Kawauchi
  • ,
  • Masafumi Suzaki
  • ,
  • Takeshi Yuasa

6
10
開始ページ
2263
終了ページ
2276
記述言語
英語
掲載種別
研究論文(学術雑誌)
出版者・発行元
E-CENTURY PUBLISHING CORP

Dormant cancer cells are deprivation-resistant, and cause a number of problems for therapeutic approaches for cancers. Renal cell carcinomas (RCCs) include deprivation-resistant cells that are resistant to various treatments. In this study, the specific characteristics of deprivation-resistant cells were transcriptionally identified by next generation sequencing. The hypoxia-inducible factors (HIF) transcription factor network was significantly enhanced in deprivation-resistant RCCs compared to the sensitive RCCs. Deprivation-resistant RCCs, that had lost Von Hippel-Lindau tumor suppressor expression, expressed hydroxyl-HIF2-alpha in the nucleus, but not sensitiveRCCs. Hydroxyl-HIF-alpha was also expressed in nuclei of RCC tissue samples. Knockdown for HIF2-alpha, but not HIF1-alpha, induced cell death related to a reduction in HIF-related gene expression in deprivation-resistant RCC cells. Chetomin, a nuclear HIF-inhibitor, induced marked level of cytotoxicity in deprivation-resistant cells, similar to the knockdown of HIF2-alpha. Therefore, hydroxyl-HIF2-alpha might be a potential therapeutic target for RCCs.

Web of Science ® 被引用回数 : 7

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27822416
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000387618300011&DestApp=WOS_CPL

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