論文

査読有り
2016年5月

Pharmacokinetics and brain penetration of carbapenems in mice

JOURNAL OF INFECTION AND CHEMOTHERAPY
  • Kazuaki Matsumoto
  • ,
  • Yuji Kurihara
  • ,
  • Yuko Kuroda
  • ,
  • Seiji Hori
  • ,
  • Junko Kizu

22
5
開始ページ
346
終了ページ
349
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jiac.2015.11.010
出版者・発行元
ELSEVIER SCIENCE BV

An adverse effect associated with the administration of carbapenems is central nervous system (CNS) toxicity, with higher brain concentrations of carbapenems being linked to an increased risk of seizures. However, the pharmacokinetics and brain penetration of carbapenems have not yet been examined. Thus, the aim of this in vivo investigation was to determine the pharmacokinetics and brain penetration of carbapenems in mice.
Blood samples and brain tissue samples were obtained 10, 20, 30, 60, and 120 min after the subcutaneous administration of carbapenems (91 mg/kg). We obtained the following values for the pharmacokinetic parameters of carbapenems in mice: 1.20-1.71 L/h/kg for CLtotal/F, 1.41-2.03 h(-1) for K-e, 0.34-0.51 h for T-1/2, 0.66-0.95 L/kg for V-ss/F, 0.49-0.73 h for MRT, 83.46-110.58 mu g/mL for C-max, (plasma), and 0.28-0.83 mu g/g for C-max,C- (brain tissue). The AUC(0-infinity) of the carbapenems tested in plasma were in the following order: doripenem > meropenem > biapenem > imipenem, and in brain tissue were: imipenem > doripenem > meropenem > biapenem. The degrees of brain tissue penetration, defined as the AUC(0-infinity), (brain) (tissue)/fAUC(0-infinity,) (plasma) ratio, were 0.016 for imipenem, 0.004 for meropenem, 0.002 for biapenem, and 0.008 for doripenem.
The results of the present study demonstrated that, of the carbapenems examined, imipenem penetrated brain tissue to the greatest extent. (C) 2015, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.jiac.2015.11.010
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000375006000015&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.jiac.2015.11.010
  • ISSN : 1341-321X
  • eISSN : 1437-7780
  • Web of Science ID : WOS:000375006000015

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