論文

査読有り
2012年

Measurement of high-molecular-weight adiponectin is not useful in assessing coronary stenosis

CLINICAL CHEMISTRY AND LABORATORY MEDICINE
  • Takuya Imatoh
  • ,
  • Motonobu Miyazaki
  • ,
  • Ken Kadowaki
  • ,
  • Shinichi Tanihara
  • ,
  • Chinami Akashi
  • ,
  • Hiroshi Une

50
4
開始ページ
741
終了ページ
745
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1515/CCLM.2011.832
出版者・発行元
WALTER DE GRUYTER & CO

Background: In many studies, high-molecular-weight (HMW) adiponectin has been considered the active form of adiponectin. However, whether HMW adiponectin is a good surrogate marker for coronary artery disease still needs to be elucidated.
Methods: We conducted a hospital-based cross-sectional study to examine the relationship between total, HMW or non-HMW adiponectin concentrations and coronary stenosis in 83 male patients and 138 male controls.
Results: Patients with coronary stenosis had significantly lower total adiponectin concentrations compared with controls. Non-HMW adiponectin concentrations in cases were significantly lower than the controls. However, there were no significant differences between cases and controls in HMW adiponectin concentrations. From the receiver operating characteristic (ROC) analysis, the area under the curve (AUC) for total and non-HMW adiponectin was significantly larger than that for HMW adiponectin concentrations. Of the three models, that for non-HMW adiponectin showed the largest AUC (total adiponectin 0.74, HMW adiponectin 0.54, and non-HMW adiponectin 0.79).
Conclusions: Despite associations between total adiponectin levels and coronary stenosis, our data go against any apparent association between HMW adiponectin concentrations and coronary stenosis.

Web of Science ® 被引用回数 : 2

リンク情報
DOI
https://doi.org/10.1515/CCLM.2011.832
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000304337100023&DestApp=WOS_CPL

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