論文

査読有り
2009年8月

Is heat shock protein 60 associated with type 2 diabetes mellitus?

DIABETES RESEARCH AND CLINICAL PRACTICE
  • T. Imatoh
  • ,
  • T. Sugie
  • ,
  • M. Miyazaki
  • ,
  • S. Tanihara
  • ,
  • M. Baba
  • ,
  • Y. Momose
  • ,
  • Y. Uryu
  • ,
  • H. Une

85
2
開始ページ
208
終了ページ
212
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.diabres.2009.06.004
出版者・発行元
ELSEVIER IRELAND LTD

Aims: HSP60 plays a protective role against heat, oxidative injury and ultraviolet. Recently, animal and clinical studies have suggested that HSP60 plays a role in various diseases. However, few epidemiological studies have demonstrated an association between HSP60 levels and type 2 diabetes mellitus. Therefore, an epidemiological study was conducted to examine the association of HSP60 with type 2 diabetes mellitus.
Methods: This study included 83 type 2 diabetes mellitus patients and 161 controls that were recruited from male employees who received annual health check-ups between 2005 and 2007. The serum HSP60 levels were measured using the ELISA method.
Results: Because the HSP60 levels were not detectable (<3.125 ng/mL) in 48.0% of the study subjects, HSP60 levels were divided into two categories (detectable or undetectable). A logistic regression analysis showed that the subjects in the undetectable had a 2.03 times higher risk of diabetes mellitus than those in the detectable after adjustment for age, BMI and rate of hypertension medication.
Conclusions: This study was the first epidemiological study to demonstrate an association between type 2 diabetes mellitus and HSP60, thus suggesting that HSP60 may play an important role in the type 2 diabetes mellitus pathology. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.1016/j.diabres.2009.06.004
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000268655800015&DestApp=WOS_CPL

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