2020年2月
What Is GLP-1 Really Doing in Obesity?
Trends in endocrinology and metabolism: TEM
- ,
- ,
- 巻
- 31
- 号
- 2
- 開始ページ
- 71
- 終了ページ
- 80
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.tem.2019.09.003
- 出版者・発行元
- ELSEVIER SCIENCE LONDON
Glucagon-like peptide-1 (GLP-1) is a gastrointestinal hormone released in response to meal ingestion and enhances insulin secretion from pancreatic β cells. In several human studies, GLP-1 secretory responses to oral glucose load or a meal were decreased in subjects with obesity, glucose intolerance, or diabetes compared with those in healthy subjects. However, the results of meta-analysis and cohort studies do not necessarily support this concept. Results from animal studies are also inconsistent; in multiple studies, GLP-1 secretory responses to a meal were repeatedly higher in diet-induced obese rats than in control rats. Thus, the postprandial GLP-1 response is not necessarily decreased but rather enhanced during obesity development, which is likely to play a protective role against glucose intolerance.
- リンク情報
-
- DOI
- https://doi.org/10.1016/j.tem.2019.09.003
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/31636017
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000508388000002&DestApp=WOS_CPL
- 共同研究・競争的資金等の研究課題
- 食事誘導性肥満におけるGLP-1分泌増大機構の解明
- 共同研究・競争的資金等の研究課題
- 食事条件に対する消化管栄養素感受性の適応機構の解明と制御
- 共同研究・競争的資金等の研究課題
- 食事誘導性肥満・耐糖能異常の発症過程におけるGLP-1の関与
- ID情報
-
- DOI : 10.1016/j.tem.2019.09.003
- ISSN : 1043-2760
- eISSN : 1879-3061
- PubMed ID : 31636017
- Web of Science ID : WOS:000508388000002