OSHIMA Masanobu

Last updated: Apr 26, 2019 at 09:40

Name	OSHIMA Masanobu

Research Interests

inflammation and cancer(1) , genetics(227) , mouse model(11)

Academic & Professional Experience

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Apr 2013

Mar 2017

Director, Cancer Research Institute, Kanazawa University

Education

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1988

Graduate School, Division of Veterinary Medicine, Hokkaido University

1986

Faculty of Veterinary Medicine, Hokkaido University

Published Papers

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Glial TLR2-driven innate immune responses and CD8⁺ T cell activation against brain tumor.

Chang CY, Jeon SB, Yoon HJ, Choi BK, Kim SS, Oshima M, Park EJ

Glia 67(6) 1179-1195 Jun 2019 [Refereed]

Deficiency of Stomach-Type Claudin-18 in Mice Induces Gastric Tumor Formation Independent of H. Pylori Infection.

Suzuki K, Sentani K, Tanaka H, Yano T, Suzuki K, Oshima M, Yasui W, Tamura A, Tsukita S

Cellular and molecular gastroenterology and hepatology Mar 2019 [Refereed]

Overexpression of IL-11 promotes premalignant gastric epithelial hyperplasia in isolation from germline gp130-JAK-STAT driver mutations.

Buzzelli JN, O'Connor L, Scurr M, Chung Nien Chin S, Catubig A, Ng GZ, Oshima M, Oshima H, Giraud AS, Sutton P, Judd LM, Menheniott TR

American journal of physiology. Gastrointestinal and liver physiology 316(2) G251-G262 Feb 2019 [Refereed]

NF-κB-induced NOX1 activation promotes gastric tumorigenesis through the expansion of SOX2-positive epithelial cells.

Echizen K, Horiuchi K, Aoki Y, Yamada Y, Minamoto T, Oshima H, Oshima M

Oncogene Jan 2019 [Refereed]

Mutant p53 in colon cancer.

Nakayama M, Oshima M

Journal of molecular cell biology Nov 2018 [Refereed]

Interleukin 1 Upregulates MicroRNA 135b to Promote Inflammation-associated Gastric Carcinogenesis in Mice.

Han TS, Voon DC, Oshima H, Nakayama M, Echizen K, Sakai E, Yong ZWE, Murakami K, Yu L, Minamoto T, Ock CY, Jenkins BJ, Kim SJ, Yang HK, Oshima M

Gastroenterology Nov 2018 [Refereed]

18β-glycyrrhetinic acid inhibited mitochondrial energy metabolism and gastric carcinogenesis through methylation regulated TLR2 signaling pathway.

Cao D, Wu Y, Jia Z, Zhao D, Zhang Y, Zhou T, Wu M, Zhang H, Tsukamoto T, Oshima M, Jiang J, Cao X

Carcinogenesis Oct 2018 [Refereed]

Stat3 is indispensable for damage-induced crypt regeneration but not for Wnt-driven intestinal tumorigenesis.

Oshima H, Kok SY, Nakayama M, Murakami K, Voon DC, Kimura T, Oshima M

FASEB journal : official publication of the Federation of American Societies for Experimental Biology fj201801176R Aug 2018 [Refereed]

Kang MH, Choi H, Oshima M, Cheong JH, Kim S, Lee JH, Park YS, Choi HS, Kweon MN, Pack CG, Lee JS, Mills GB, Myung SJ, Park YY

Nature communications 9(1) 1920 May 2018 [Refereed]

The inflammatory microenvironment that promotes gastrointestinal cancer development and invasion.

Echizen K, Oshima H, Nakayama M, Oshima M

Advances in biological regulation 68 39-45 May 2018 [Refereed]

Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism.

Deswaerte V, Nguyen P, West A, Browning AF, Yu L, Ruwanpura SM, Balic J, Livis T, Girard C, Preaudet A, Oshima H, Fung KY, Tye H, Najdovska M, Ernst M, Oshima M, Gabay C, Putoczki T, Jenkins BJ

Cancer research 78(5) 1293-1307 Mar 2018 [Refereed]

Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer.

Sakai E, Nakayama M, Oshima H, Kouyama Y, Niida A, Fujii S, Ochiai A, Nakayama KI, Mimori K, Suzuki Y, Hong CP, Ock CY, Kim SJ, Oshima M

Cancer research 78(5) 1334-1346 Mar 2018 [Refereed]

Functional loss of p53 cooperates with the in vivo microenvironment to promote malignant progression of gastric cancers.

Ohtsuka J, Oshima H, Ezawa I, Abe R, Oshima M, Ohki R

Scientific reports 8(1) 2291 Feb 2018 [Refereed]

Laser Microdissection of Cellular Compartments for Expression Analyses in Cancer Models.

Han TS, Oshima M

Methods in molecular biology (Clifton, N.J.) 1725 143-153 2018 [Refereed]

Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation.

Nakayama M, Sakai E, Echizen K, Yamada Y, Oshima H, Han TS, Ohki R, Fujii S, Ochiai A, Robine S, Voon DC, Tanaka T, Taketo MM, Oshima M

Oncogene 36(42) 5885-5896 Oct 2017 [Refereed]

Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer.

West AC, Tang K, Tye H, Yu L, Deng N, Najdovska M, Lin SJ, Balic JJ, Okochi-Takada E, McGuirk P, Keogh B, McCormack W, Bhathal PS, Reilly M, Oshima M, Ushijima T, Tan P, Jenkins BJ

Oncogene 36(36) 5134-5144 Sep 2017 [Refereed]

Inflammation in gastric cancer: Interplay of the COX-2/prostaglandin E2 and Toll-like receptor/MyD88 pathways.

Echizen K, Hirose O, Maeda Y, Oshima M

Cancer science 107(4) 391-397 Apr 2016 [Refereed]

NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition.

Madan B, Ke Z, Lei ZD, Oliver FA, Oshima M, Lee MA, Rozen S, Virshup DM

Oncotarget 7(11) 12386-12392 Mar 2016 [Refereed]

Myeloid Differentiation Factor 88 Signaling in Bone Marrow-Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment.

Maeda Y, Echizen K, Oshima H, Yu L, Sakulsak N, Hirose O, Yamada Y, Taniguchi T, Jenkins BJ, Saya H, Oshima M

Cancer prevention research (Philadelphia, Pa.) 9(3) 253-263 Mar 2016 [Refereed]

Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells.

Naka K, Jomen Y, Ishihara K, Kim J, Ishimoto T, Bae EJ, Mohney RP, Stirdivant SM, Oshima H, Oshima M, Kim DW, Nakauchi H, Takihara Y, Kato Y, Ooshima A, Kim SJ

Nature communications 6 8039 Aug 2015 [Refereed]