2007年10月
Soymorphins, Novel μ Opioid Peptides Derived from Soy β-Conglycinin β-Subunit, Have Anxiolytic Activities
Bioscience, biotechnology, and biochemistry
- ,
- ,
- 巻
- 71
- 号
- 10
- 開始ページ
- 2618
- 終了ページ
- 2621
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1271/bbb.70516
- 出版者・発行元
- Japan Society for Bioscience, Biotechnology, and Agrochemistry
Based on the amino acid sequence YPFV found in the soy β-conglycinin β-subunit, which is common to an opioid peptide human β-casomorphin-4, peptides YPFVV, YPFVVN, and YPFVVNA were synthesized according to their primary structure. On guinea pig ileum (GPI) assay, they showed opioid activity (IC<SUB>50</SUB> = 6.0, 9.2 and 13 μ<small>M</small> respectively) more potent than human β-casomorphins, and were named soymorphins-5, -6, and -7, respectively. Their opioid activities on mouse vas deferens (MVD) assay were less potent than on GPI assay, suggesting that they are selective for the μ opioid receptor. Human β-casomorphin-4 and soymorphin-5 were released from the soy 7S fraction (β-conglycinin) by the action of gastrointestinal proteases. Soymorphins-5, -6, and -7 had anxiolytic activities after oral administration at doses of 10–30 mg/kg in the elevated plus-maze test in mice.
- リンク情報
- ID情報
-
- DOI : 10.1271/bbb.70516
- ISSN : 0916-8451
- eISSN : 1347-6947
- CiNii Articles ID : 10027520485
- identifiers.cinii_nr_id : 9000004456776
- Web of Science ID : WOS:000250669000044