2008年1月
A potent hypotensive peptide, novokinin, induces relaxation by AT(2)- and IP-receptor-dependent mechanism in the mesenteric artery from SHRs
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
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- 巻
- 72
- 号
- 1
- 開始ページ
- 257
- 終了ページ
- 259
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1271/bbb.70638
- 出版者・発行元
- TAYLOR & FRANCIS LTD
In this study, we found that novokinin (Arg-Pro-Leu-Lys-Pro-Trp), a potent hypotensive peptide acting through the AT(2) receptor, has vasorelaxing activity in the mesenteric artery isolated from spontaneously hypertensive rats. The vasorelaxing activity was significantly blocked by PD123319, indomethacin, and CAY10441, which are an AT(2) receptor antagonist, a cyclooxygenase inhibitor, and an IP receptor antagonist, respectively. N-G-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase, did not block the vasorelaxing activity. These results suggest that the vasorelaxing activity of novokinin, which contributes to the hypotensive effect, is mainly mediated by prostaglandin 12 (prostacyclin) and the IP receptor downstream of the AT(2) receptor.
- リンク情報
- ID情報
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- DOI : 10.1271/bbb.70638
- ISSN : 0916-8451
- eISSN : 1347-6947
- PubMed ID : 18175894
- Web of Science ID : WOS:000252842200039