論文

査読有り
2008年1月

A potent hypotensive peptide, novokinin, induces relaxation by AT(2)- and IP-receptor-dependent mechanism in the mesenteric artery from SHRs

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
  • Yuko Yamada
  • ,
  • Daiki Yamauchi
  • ,
  • Megurni Yokoo
  • ,
  • Kousaku Ohinata
  • ,
  • Hachiro Usui
  • ,
  • Masaaki Yoshikawa

72
1
開始ページ
257
終了ページ
259
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1271/bbb.70638
出版者・発行元
TAYLOR & FRANCIS LTD

In this study, we found that novokinin (Arg-Pro-Leu-Lys-Pro-Trp), a potent hypotensive peptide acting through the AT(2) receptor, has vasorelaxing activity in the mesenteric artery isolated from spontaneously hypertensive rats. The vasorelaxing activity was significantly blocked by PD123319, indomethacin, and CAY10441, which are an AT(2) receptor antagonist, a cyclooxygenase inhibitor, and an IP receptor antagonist, respectively. N-G-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase, did not block the vasorelaxing activity. These results suggest that the vasorelaxing activity of novokinin, which contributes to the hypotensive effect, is mainly mediated by prostaglandin 12 (prostacyclin) and the IP receptor downstream of the AT(2) receptor.

リンク情報
DOI
https://doi.org/10.1271/bbb.70638
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/18175894
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000252842200039&DestApp=WOS_CPL
ID情報
  • DOI : 10.1271/bbb.70638
  • ISSN : 0916-8451
  • eISSN : 1347-6947
  • PubMed ID : 18175894
  • Web of Science ID : WOS:000252842200039

エクスポート
BibTeX RIS