2007年3月
Suppression of food intake by a complement C3a agonist [Trp(5)]-oryzatensin(5-9)
PEPTIDES
- ,
- ,
- ,
- 巻
- 28
- 号
- 3
- 開始ページ
- 602
- 終了ページ
- 606
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.peptides.2006.11.020
- 出版者・発行元
- ELSEVIER SCIENCE INC
[Trp(5)]-oryzatensin(5-9) (WPLPR), an agonist peptide for complement C3a. receptor, has been designed based on the C-terminal region of ileum-contracting peptide oryzatensin derived from rice protein. We previously reported that WPLPR has anti-analgesic and anti-amnesic activities after central or oral administration. In this study, we found a novel function of WPLPR on food intake. WPLPR suppressed food intake after intracerebroventricular or intraperitoneal (i.p.) administration at a dose of 3-30 nmol/mouse or 30-300 mg/kg, respectively, in fasted mice. orally administered WPLPR at a dose of 300 mg/kg also decreased food intake. WPLPR decreased gastric emptying after i.p. injection at a dose of 300 mg/kg. The anorexigenic activity of WPLPR was blocked by cyclooxygenase inhibitor or antagonist for prostaglandin (PG) E receptor EP4 subtype. These results suggest that WPLPR decreases food intake through PGE(2) production followed by EP4 receptor activation. (c) 2006 Elsevier Inc. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.peptides.2006.11.020
- ISSN : 0196-9781
- PubMed ID : 17207895
- Web of Science ID : WOS:000244611700014