2007年3月
Enterostatin (APGPR) enhances memory consolidation in mice
PEPTIDES
- ,
- ,
- ,
- 巻
- 28
- 号
- 3
- 開始ページ
- 719
- 終了ページ
- 721
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.peptides.2006.11.003
- 出版者・発行元
- ELSEVIER SCIENCE INC
Enterostatin (APGPR) is a pentapeptide released from its precursor protein, procolipase. We found for the first time that enterostatin has memory-enhancing activity. Enterostatin enhanced memory consolidation after central or oral administration at a dose of 10 nmol/mouse or 300 mg/kg, respectively, in a step-through type passive avoidance test in mice. The memory-enhancing activity of enterostatin was inhibited by pretreatment with lorglumide, an antagonist for cholecystokinin 1 (CCK1) receptor. However, enterostatin had no affinity for CCK receptors. These results suggest that enterostatin improves memory retention through CCK release. (c) 2006 Elsevier Inc. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.peptides.2006.11.003
- ISSN : 0196-9781
- PubMed ID : 17175068
- Web of Science ID : WOS:000244611700031