論文

査読有り
2007年3月

Enterostatin (APGPR) enhances memory consolidation in mice

PEPTIDES
  • Kousaku Ohinata
  • ,
  • Soushi Sonoda
  • ,
  • Tomoko Shimano
  • ,
  • Masaaki Yoshikawa

28
3
開始ページ
719
終了ページ
721
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.peptides.2006.11.003
出版者・発行元
ELSEVIER SCIENCE INC

Enterostatin (APGPR) is a pentapeptide released from its precursor protein, procolipase. We found for the first time that enterostatin has memory-enhancing activity. Enterostatin enhanced memory consolidation after central or oral administration at a dose of 10 nmol/mouse or 300 mg/kg, respectively, in a step-through type passive avoidance test in mice. The memory-enhancing activity of enterostatin was inhibited by pretreatment with lorglumide, an antagonist for cholecystokinin 1 (CCK1) receptor. However, enterostatin had no affinity for CCK receptors. These results suggest that enterostatin improves memory retention through CCK release. (c) 2006 Elsevier Inc. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.peptides.2006.11.003
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/17175068
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000244611700031&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.peptides.2006.11.003
  • ISSN : 0196-9781
  • PubMed ID : 17175068
  • Web of Science ID : WOS:000244611700031

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