2017年11月
Obesity-promoting and anti-thermogenic effects of neutrophil gelatinase-associated lipocalin in mice
SCIENTIFIC REPORTS
- 巻
- 7
- 号
- 1
- 開始ページ
- 15501
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41598-017-15825-4
- 出版者・発行元
- NATURE PUBLISHING GROUP
Neutrophil gelatinase-associated lipocalin (NGAL, lipocalin 2 or LCN2) is an iron carrier protein whose circulating level is increased by kidney injury, bacterial infection and obesity, but its metabolic consequence remains elusive. To study physiological role of LCN2 in energy homeostasis, we challenged female Lcn2 knockout (KO) and wild-type (WT) mice with high fat diet (HFD) or cold exposure. Under normal diet, physical constitutions of Lcn2 KO and WT mice were indistinguishable. During HFD treatment, Lcn2 KO mice exhibited larger brown adipose tissues (BAT), consumed more oxygen, ate more food and gained less body weights as compared to WT mice. When exposed to 4 degrees C, KO mice showed higher body temperature and more intense F-18-fluorodeoxyglucose uptake in BAT, which were cancelled by beta 3 adrenergic receptor blocker or iron-loaded (but not iron-free) LCN2 administration. These findings suggest that circulating LCN2 possesses obesity-promoting and anti-thermogenic effects through inhibition of BAT activity in an iron-dependent manner.
- リンク情報
- ID情報
-
- DOI : 10.1038/s41598-017-15825-4
- ISSN : 2045-2322
- PubMed ID : 29138470
- Web of Science ID : WOS:000415165500002