2001年9月
Growth inhibition by keratinocyte growth factor receptor of human salivary adenocarcinoma cells through induction of differentiation and apoptosis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- 巻
- 98
- 号
- 20
- 開始ページ
- 11336
- 終了ページ
- 11340
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1073/pnas.191377098
- 出版者・発行元
- NATL ACAD SCIENCES
We have reported that normal human salivary gland-derived epithelial cells exclusively express keratinocyte growth factor receptor (KGFR). In the process of malignant transformation of human salivary gland tumors, KGFR gene expression disappeared concomitantly with the de novo expression of the fibroblast growth factor receptor 1 (FGFR1) and FGFR4 genes. In the present study, we introduced wild-type KGFR cDNA or chimeric KGFR/ FGFR1 cDNA, which encoded the extracellular domain of KGFR and the intracellular domain of FGFR1, into the HSY human salivary adenocarcinoma cell line. The KGFR tyrosine kinase suppressed the activity of FGF receptor substrate 2 (FRS2) and inhibited the growth of HSY by inducing differentiation and apoptosis in vitro and in vivo. Our results provided significant insight into the mechanism of KGFR tumor suppression and suggest that KGFR gene therapy might be a viable method of inhibiting human salivary adenocarcinoma growth.
- リンク情報
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- DOI
- https://doi.org/10.1073/pnas.191377098
- CiNii Articles
- http://ci.nii.ac.jp/naid/30016219902
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/11562460
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000171237100065&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1073/pnas.191377098
- ISSN : 0027-8424
- CiNii Articles ID : 30016219902
- PubMed ID : 11562460
- Web of Science ID : WOS:000171237100065