HIRAYAMA Aki

J-GLOBAL         Last updated: Dec 15, 2018 at 09:40
 
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Name
HIRAYAMA Aki
Affiliation
Tsukuba University of Technology
Section
Faculty of Health Sciences
Job title
Professor
Degree
Doctor (Medicine)(University of Tsukuba)

Research Areas

 
 

Academic & Professional Experience

 
1999
   
 
- Assistant Professor
 
 
   
 
Graduate School of Comprehensive Human Sciences
 
 
   
 
Medical Sciences for Control of Pathological Processes
 
 
   
 
University of Tsukuba
 
1996
 - 
1997
 Institute of Urology & Nephrology, University College London,Visiting Research Fellow
 

Education

 
 
 - 
1991
School of Medicine, University of Tsukuba
 

Awards & Honors

 
Aug 2016
The SFRR Japan Award of Scientific Excellence, Society for Free Radical Research Japan
 
Feb 2016
DEVELOPMENT OF SILICA-CONTAINING REDOX NANO-PARTICLE FOR PREVENTION OF ENCAPSULATING PERITONEAL SCLEROSIS AND HIGH PERFORMANCE PERITONEAL DIALYSIS, Best Abstract, 16th Congress of the International Society for Peritoneal Dialysis (ISPD 2016)
 
2000
Young Investigator's Award of the Japanese Society of Internal Medicine
 
2005
The SFRR Japan Award for Young Scientists
 

Published Papers

 
Xu D, Murakoshi N, Igarashi M, Hirayama A, Ito Y, Seo Y, Tada H, Aonuma K
Journal of cardiovascular electrophysiology   23(2) 209-217   Feb 2012   [Refereed]
Xu D, Murakoshi N, Igarashi M, Hirayama A, Ito Y, Seo Y, Tada H, Aonuma K, Journal of cardiovascular electrophysiology, 2012, vol. 23, no. 2, pp. 209-217, 2012
Hirayama Aki, Oowada Shigeru, Ito Hiromu, Matsui Hirofumi, Ueda Atsushi, Aoyagi Kazumasa
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   62(1) 39-48   Jan 2018   [Refereed]
Hirayama Aki, Miura Misa, Yasuda Go, Nagano Yumiko, Matsui Hirofumi, Hirayama Yoh, Ueda Atsushi, Aoyagi Kazumasa, Kohzuki Masahiro, Oowada Shigeru
FREE RADICAL BIOLOGY AND MEDICINE   112 131-132   Nov 2017   [Refereed]
Yoshitomi T, Hirayama A, Nagasaki Y
Biomaterials   32(31) 8021-8028   Nov 2011   [Refereed]
Yoshitomi T, Hirayama A, Nagasaki Y, Biomaterials, 2011, vol. 32, no. 31, pp. 8021-8028, 2011
Nagasaki Y, Yaguchi T, Matsumura T, Yoshitomi T, Ikeda Y, Ueda A, Hirayama A
Biomaterials science   2(4) 522-529   Mar 2014   [Refereed]
Nagasaki Y, Yaguchi T, Matsumura T, Yoshitomi T, Ikeda Y, Ueda A, Hirayama A, Biomaterials science, 2014, vol. 2, no. 4, pp. 522-529, 2014
Tomita Tsutomu, Hirayama Aki, Matsui Hirofumi, Aoyagi Kazumasa
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE   1-7   2017   [Refereed]
Hirayama A, Okamoto T, Kimura S, Nagano Y, Matsui H, Tomita T, Oowada S, Aoyagi K
Journal of clinical biochemistry and nutrition   58(3) 173-173   May 2016   [Refereed]
Hirayama A, Okamoto T, Kimura S, Nagano Y, Matsui H, Tomita T, Oowada S, Aoyagi K, Journal of clinical biochemistry and nutrition, 2016, vol. 58, no. 3, pp. 167-173, 2016
Ito Hiromu, Kurokawa Hiromi, Hirayama Aki, Indo Hiroko P., Majima Hideyuki J., Matsui Hirofumi
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   61(3) 183-188   Nov 2017   [Refereed]
Rai K, Matsui H, Kaneko T, Nagano Y, Shimokawa O, Udo J, Hirayama A, Hyodo I, Indo HP, Majima HJ
Journal of clinical biochemistry and nutrition   49(1) 25-30   Jul 2011   [Refereed]
Rai K, Matsui H, Kaneko T, Nagano Y, Shimokawa O, Udo J, Hirayama A, Hyodo I, Indo HP, Majima HJ, Journal of clinical biochemistry and nutrition, 2011, vol. 49, no. 1, pp. 25-30, 2011
Ito H, Matsui H, Hirayama A, Indo HP, Majima HJ, Hyodo I
Journal of clinical biochemistry and nutrition   58(3) 185-185   May 2016   [Refereed]
Ito H, Matsui H, Hirayama A, Indo HP, Majima HJ, Hyodo I, Journal of clinical biochemistry and nutrition, 2016, vol. 58, no. 3, pp. 180-185, 2016
Hirayama Aki, Matsuzaki Hideo
FREE RADICAL BIOLOGY AND MEDICINE   112 132   Nov 2017   [Refereed]
Marushima A, Suzuki K, Nagasaki Y, Yoshitomi T, Toh K, Tsurushima H, Hirayama A, Matsumura A
Neurosurgery   68(5) 1418-1426   May 2011   [Refereed]
Nagano Y, Matsui H, Shimokawa O, Hirayama A, Nakamura Y, Tamura M, Rai K, Kaneko T, Hyodo I
Journal of clinical biochemistry and nutrition   51(3) 196-203   Nov 2012   [Refereed]
Nagano Y, Matsui H, Shimokawa O, Hirayama A, Nakamura Y, Tamura M, Rai K, Kaneko T, Hyodo I, Journal of clinical biochemistry and nutrition, 2012, vol. 51, no. 3, pp. 196-203, 2012
Miura Misa, Hirayama Aki, Oowada Shigeru, Kohzuki Masahiro, Ito Osamu
NEPHROLOGY DIALYSIS TRANSPLANTATION   30    May 2015   [Refereed]
Matsui H, Nagano Y, Shimokawa O, Kaneko T, Rai K, Udo J, Hirayama A, Nakamura Y, Indo HP, Majima HJ, Hyodo I
Journal of gastroenterology   46(10) 1167-1176   Oct 2011   [Refereed]
Matsui H, Nagano Y, Shimokawa O, Kaneko T, Rai K, Udo J, Hirayama A, Nakamura Y, Indo HP, Majima HJ, Hyodo I, Journal of gastroenterology, 2011, vol. 46, no. 10, pp. 1167-1176, 2011
Hosoo Hisayuki, Marushima Aiki, Nagasaki Yukio, Hirayama Aki, Ito Hiromu, Puentes Sandra, Mujagic Arnela, Tsurushima Hideo, Tsuruta Wataro, Suzuki Kensuke, Matsui Hirofumi, Matsumaru Yuji, Yamamoto Tetsuya, Matsumura Akira
STROKE   48(8) 2238-+   Aug 2017   [Refereed]
Hosoo Hisayuki, Marushima Aiki, Nagasaki Yukio, Hirayama Aki, Ito Hiromu, Niwano Ami, Tsurushima Hideo, Tsuruta Wataro, Suzuki Kensuke, Yamamoto Tetsuya, others
Journal of Stroke and Cerebrovascular Diseases   26(4) 913   2017   [Refereed]
Suzuki H, Kaneko T, Mizokami Y, Narasaka T, Endo S, Matsui H, Yanaka A, Hirayama A, Hyodo I
World journal of gastroenterology   19(17) 2718-2722   May 2013   [Refereed]
Suzuki H, Kaneko T, Mizokami Y, Narasaka T, Endo S, Matsui H, Yanaka A, Hirayama A, Hyodo I, World journal of gastroenterology, 2013, vol. 19, no. 17, pp. 2718-2722, 2013
Nagasaki Yukio, Ikeda Yutaka, Yoshitomi Toru, Yaguchi Tatsuya, Yamashita Mayo, Hossain Md Amran, Yoshinari Tomoki, Ueda Atsushi, Hirayama Aki, others
   May 2016   [Refereed]
US Patent 9,333,265
Pua ML, Yoshitomi T, Chonpathompikunlert P, Hirayama A, Nagasaki Y
Journal of controlled release : official journal of the Controlled Release Society   172(3) 914-920   Dec 2013   [Refereed]
Pua ML, Yoshitomi T, Chonpathompikunlert P, Hirayama A, Nagasaki Y, Journal of controlled release : official journal of the Controlled Release Society, 2013, vol. 172, no. 3, pp. 914-920, 2013
Ito H, Matsui H, Hirayama A, Indo H.P, Majima H.J, Hyodo I.
Journal of Clinical Biochemistry and Nutrition   58(3) 180-185   2016   [Refereed]
Hirayama A, Okamoto T, Kimura S, Nagano Y, Matsui H, Tomita T, Oowada S, Aoyagi K.
Journal of Clinical Biochemistry and Nutrition   58(3) 167-173   2016   [Refereed]
Ito Hiromu, Matsui Hirofumi, Hirayama Aki, Indo Hiroko P, Majima Hideyuki J, Hyodo Ichinosuke
Journal of clinical biochemistry and nutrition   58(3) 180   2016   [Refereed]
Hirayama Aki, Okamoto Takuya, Kimura Satomi, Nagano Yumiko, Matsui Hirofumi, Tomita Tsutomu, Oowada Shigeru, Aoyagi Kazumasa
Journal of clinical biochemistry and nutrition   58(3) 167   2016   [Refereed]
Hirayama K, Ishizu T, Shimohata H, Miyamoto Y, Kakita T, Nagai M, Ogawa Y, Fujita S, Hirayama A, Yamagata K, Kobayashi M, Koyama A
Clinical and experimental nephrology   14(1) 36-42   Feb 2010   [Refereed]
Hirayama K, Ishizu T, Shimohata H, Miyamoto Y, Kakita T, Nagai M, Ogawa Y, Fujita S, Hirayama A, Yamagata K, Kobayashi M, Koyama A, Clinical and experimental nephrology, 2010, vol. 14, no. 1, pp. 36-42, 2010
Hirayama Aki, Matsuzaki Hideo
Free Radical Biology and Medicine   100 S191   2016   [Refereed]
Nagasaki Yukio, Yoshitomi Toru, Matsui Hirofumi, Hirayama Aki, Mamiya Takashi, Matsumura Akira, Suzuki Kensuke, Tsurushima Hideo, Marushima Aiki, Toh Kazuko, others
   Mar 2015   [Refereed]
US Patent 8,980,241
Miura Misa, Hirayama Aki, Oowada Shigeru, Kohzuki Masahiro, Ito Osamu
Nephrology Dialysis Transplantation   30(suppl 3) iii524   2015   [Refereed]
Masuda K, Hori T, Tanabe K, Kano Y, Hirayama A, Nagase S
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme   32(6) 1097-1104   Dec 2007   [Refereed]
Nagasaki Y, Yaguchi T, Matsumura T, Yoshitomi T, Ikeda Y, Ueda A, Hirayama A.
Biomaterials Science   2(4) 522-529   2014   [Refereed]
Mamiya T, Katsuoka F, Hirayama A, Nakajima O, Kobayashi A, Maher JM, Matsui H, Hyodo I, Yamamoto M, Hosoya T
The Tohoku journal of experimental medicine   216(4) 331-339   Dec 2008   [Refereed]
Mamiya T, Katsuoka F, Hirayama A, Nakajima O, Kobayashi A, Maher JM, Matsui H, Hyodo I, Yamamoto M, Hosoya T, The Tohoku journal of experimental medicine, 2008, vol. 216, no. 4, pp. 331-339, 2008
Suzuki H, Kaneko T, Mizokami Y, Narasaka T, Endo S, Matsui H, Yanaka A, Hirayama A, Hyodo I.
World Journal of Gastroenterology   19(17) 2718-2722   2013   [Refereed]
Pua M.L, Yoshitomi T, Chonpathompikunlert P, Hirayama A, Nagasaki Y.
Journal of Controlled Release   172(3) 914-920   2013   [Refereed]
Nagano Y, Matsui H, Shimokawa O, Hirayama A, Tamura M, Nakamura Y, Kaneko T, Rai K, Indo HP, Majima HJ, Hyodo I, Journal of physiology, pharmacology : an official journal of the Polish Physiological Society, vol. 63, no. 2, pp. 137-142
63(2) 137-142   Apr 2012   [Refereed]
Nagano Y, Matsui H, Shimokawa O, Hirayama A, Tamura M, Nakamura Y, Kaneko T, Rai K, Indo HP, Majima HJ, Hyodo I, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2012, vol. 63, no. 2, pp. 137-142, 2012
Nagano Y, Matsui H, Shimokawa O, Hirayama A, Tamura M, Nakamura Y, Kaneko T, Rai K, Indo H.P, Majima H.J, Hyodo I.
Journal of Physiology and Pharmacology   63(2) 137-142   2012   [Refereed]
Xu D, Murakoshi N, Igarashi M, Hirayama A, Ito Y, Seo Y, Tada H, Aonuma K.
Journal of Cardiovascular Electrophysiology   23(2) 209-217   2012   [Refereed]
Nagano Y, Matsui H, Shimokawa O, Hirayama A, Nakamura Y, Tamura M, Rai K, Kaneko T, Hyodo I.
Journal of Clinical Biochemistry and Nutrition   51(3) 196-203   2012   [Refereed]
Marushima A, Suzuki K, Nagasaki Y, Yoshitomi T, Toh K, Tsurushima H, Hirayama A, Matsumura A, Neurosurgery, vol. 68, no. 5, pp. 1418-25; discussion 1425-6
68(5) 1418-25; discussion 1425   May 2011   [Refereed]
Marushima A, Suzuki K, Nagasaki Y, Yoshitomi T, Toh K, Tsurushima H, Hirayama A, Matsumura A, Neurosurgery, 2011, vol. 68, no. 5, pp. 1418-25; discussion 1425-6, 2011
Yoshitomi T, Hirayama A, Nagasaki Y.
Biomaterials   32(31) 8021-8028   2011   [Refereed]
Owada S, Maeba T, Sugano Y, Hirayama A, Ueda A, Nagase S, Goto S, Nishijima F, Bannai K, Yamato H, Nephron. Experimental nephrology, vol. 115, no. 4, pp. e101-11
Nephron - Experimental Nephrology   115(4) 101-111   2010   [Refereed]
Owada S, Maeba T, Sugano Y, Hirayama A, Ueda A, Nagase S, Goto S, Nishijima F, Bannai K, Yamato H, Nephron. Experimental nephrology, 2010, vol. 115, no. 4, pp. e101-11, 2010
Rai K, Matsui H, Kaneko T, Nagano Y, Shimokawa O, Udo J, Hirayama A, Hyodo I, Indo H.P, Majima H.J.
Journal of Clinical Biochemistry and Nutrition   49(1) 25-30   2011   [Refereed]
Matsui H, Nagano Y, Shimokawa O, Kaneko T, Rai K, Udo J, Hirayama A, Nakamura Y, Indo H.P, Majima H.J, Hyodo I.
Journal of gastroenterology   46(10) 1167-1176   2011   [Refereed]
Matsui H, Nagano Y, Shimokawa O, Kaneko T, Rai K, Udo J, Hirayama A, Nakamura Y, Indo H.P, Majima H.J, Hyodo I.
Journal of Gastroenterology   1-10   2011   [Refereed]
Owada S, Maeba T, Sugano Y, Hirayama A, Ueda A, Nagase S, Goto S, Nishijima F, Bannai K, Yamato H.
Nephron - Experimental Nephrology   115(4)    2010   [Refereed]
Ueda Atsushi, Hirayama Aki, Owada Shigeru, Nagai Kei, Saito Chie, Yamagata Kunihiro
NEPHROLOGY DIALYSIS TRANSPLANTATION   29 515   May 2014   [Refereed]
Ueda Atsushi, Iwase Mamiko, Usui Toshiaki, Hirayama Aki, Nagai Kei, Saito Chie, Yamagata Kunihiro
NEPHROLOGY DIALYSIS TRANSPLANTATION   29 472-473   May 2014   [Refereed]
Hirayama K, Ishizu T, Shimohata H, Miyamoto Y, Kakita T, Nagai M, Ogawa Y, Fujita S, Hirayama A, Yamagata K, Kobayashi M, Koyama A.
Clinical and Experimental Nephrology   14(1) 36-42   2010   [Refereed]
Matsui Hirofumi, Shimokawa Osamu, Nagano Yumiko, Kaneko Tsuyoshi, Udo Jumpei, Rai Kanho, Nakahara Akira, Hirayama Aki, Indo Hiroko, Majima Hideyuki J, others
Gastroenterology   138(5) S   2010   [Refereed]
Ueda A, Nagase S, Yokoyama H, Tada M, Ohya H, Kamada H, Hirayama A, Koyama A
Free radical biology & medicine   33(8) 1082-1088   Oct 2002   [Refereed]
Ueda A, Nagase S, Yokoyama H, Tada M, Ohya H, Kamada H, Hirayama A, Koyama A, Free radical biology & medicine, 2002, vol. 33, no. 8, pp. 1082-1088, 2002
Segerer Stephan, Jedlicka Jan, W{ü}thrich Rudolf P, Paslakis Georgios, Keuneke Christian, Groene Hermann-Josef, Schroppel Bernd, Schmid Holger, Schloendorff Detlef, Owada Shigeru, others
Nephron Experimental Nephrology   115(4) e132   2010   [Refereed]

Misc

 
Hirayama A, Ueda A, Oteki T, Nagase S, Aoyagi K, Koyama A.
Hypertension Research   31(8) 1643-1650   2008
Yoh K, Hirayama A, Ishizaki K, Yamada A, Takeuchi M, Yamagishi S, Morito N, Nakano T, Ojima M, Shimohata H, Itoh K, Takahashi S, Yamamoto M.
Genes to Cells   13 1159-1170   2008
Ogura A, Oowada S, Kon Y, Hirayama A, Yasui H, Meike S, Kobayashi S, Kuwabara M, Inanami O.
Cancer Lett.   277(1) 64-71   2009
Yoshitomi T, Suzuki R, Mamiya T, Matsui H, Hirayama A, Nagasaki Y.
Bioconjugate Chem.   20(9) 1792-1798   2009
Atsushi Ueda, Atsushi Ueda, Aki Hirayama, Sohji Nagase, Mariko Inoue, Takaaki Oteki, Masaaki Aoyama, Hidekatsu Yokoyama, Hidekatsu Yokoyama
Free Radical Research   41(7) 823-828   Jul 2007
Intrinsic reactive oxygen species (ROS) in a rat model of human minimal change nephropathy were detected directly using an in vivo electron paramagnetic resonance (EPR) method with 1-acetoxy-3-carbamoyl-2,2,5,5-tetramethylpyrrolidine (ACP) in real...
K. Tanabe, K. Tanabe, K. Masuda, A. Hirayama, S. Nagase, I. Kono, S. Kuno
Acta Physiologica   186 119-125   Jan 2006
Aims: The effect of physical activity on antioxidant capacity in muscle remains unknown. This study investigated the effect of spontaneous exercise on antioxidant capacity in rat muscles determined by electron spin resonance (ESR), which is a tech...
Sohji Nagase, Aki Hirayama, Atsushi Ueda, Takaaki Oteki, Kenji Takada, Mariko Inoue, Yukari Shimozawa, Junji Terao, Akio Koyama
Clinical Chemistry   51 2397-2398   Dec 2005
Takaaki Oteki, Sohji Nagase, Hidekatsu Yokoyama, Hiroaki Ohya, Takao Akatsuka, Mika Tada, Atsushi Ueda, Aki Hirayama, Akio Koyama
Biochemical and Biophysical Research Communications   337(1) 48-51   Nov 2005
Reactive oxygen species play an important role in adriamycin (ADR) nephropathy. We showed by in vivo electron paramagnetic resonance (EPR) that renal reducing ability (RRA) declined on the 7th day after ADR administration. Proteinuria appeared aft...
Hirayasu Kai, Kunihiro Yamagata, Joichi Usui, Yoshio Shimizu, Aki Hirayama, Keigyou Yoh, Kaori Mase, Kouichi Hirayama, Sohji Nagase, Michio Nagata, Koji Kawai, Hideyuki Akaza, Akio Koyama
Journal of Nephrology   18(4) 436-41   Jul 2005
A 59 year-old woman showed rapidly progressive glomerulonephritis during immunotherapy for metastatic renal cell carcinoma. She received unilateral nephrectomy and cytotoxic T lymphocyte (CTL) therapy for the treatment of retroperitoneal lymph nod...
Takaaki Oteki, Sohji Nagase, Hidekatsu Yokoyama, Hiroaki Ohya, Takao Akatsuka, Mika Tada, Atsushi Ueda, Aki Hirayama, Akio Koyama
Biochemical and Biophysical Research Communications   332 326-331   Jul 2005
A rat model for human minimal change nephropathy was obtained by the intravenous injection of adriamycin (ADR) at 5 mg/kg. By using an in vivo electron paramagnetic resonance (EPR) spectrometer operating at 700 MHz, the temporal changes in signal ...
Yoshio Shimizu, Yoshio Shimizu, Kazumi Suzukawa, Yuko Hirano, Masanori Seki, Kouichi Hirayama, Keigyo Yoh, Aki Hirayama, Kunihiro Yamagata, Sohji Nagase, Toshiro Nagasawa, Akio Koyama
Nephrology   10(2) 147-50   Apr 2005
A diabetic predialysis patient who had significantly reduced sensitivity to erythropoietin therapy was admitted to Tsukuba University Hospital. Many factors that might have been the cause of the erythropoietin resistance were examined, and a diagn...
Aki Hirayama, Aki Hirayama, Sohji Nagase, Atsushi Ueda, Atsushi Ueda, Takaaki Oteki, Takaaki Oteki, Kenji Takada, Mami Obara, Mariko Inoue, Keigyou Yoh, Kouichi Hirayama, Akio Koyama
American Journal of Physiology - Renal Physiology   288 F597-603   Mar 2005
Oxidative stress during ischemia-reperfusion acute renal failure (IR-ARF) was noninvasively evaluated with in vivo electron paramagnetic resonance (EPR) imaging. Female ICR mice underwent left nephrectomy and 30-min ischemia-reperfusion of the rig...
Nephron Clinical Practice   106 162-8   2007
Nephron Clinical Practice   103 c71-c76   2006
Oteki T, Nagase S, Shimohata H, Hirayama A, Ueda A, Yokoyama H, Yoshimura T
Free Radic Res.   42(2) 154-161   2008
Kidney International   68 1373-74   2005
Biochemical and Biophysical Research Communications   339(1) 226-231   2005
T. Oteki, S. Nagase, A. Hirayama, H. Sugimoto, K. Hirayama, K. Hattori, A. Koyama
Clinical Nephrology   62(1) 62-65   Jul 2004
A 70-year-old man was refferred to our hospital with the chief complaint of gross hematuria. Urinalysis revealed gross hematuria (3+, RBC 100/HPF or more) and mild proteinuria (3+, 1.8 g/day) with no urinary casts. Computed tomography of the abdom...
Kouichi Hirayama, Masaki Kobayashi, Yuko Hashimoto, Joichi Usui, Yoshio Shimizu, Aki Hirayama, Keigyou Yoh, Kunihiro Yamagata, Sohji Nagase, Michio Nagata, Akio Koyama
American Journal of Kidney Diseases   44(1) 57-63   Jul 2004
Background:The common treatment for antineutrophil cytoplasmic autoantibody (ANCA)-associated renal vasculitis is oral cyclophosphamide (CYC)-corticosteroid combination therapy. However, there are serious complications associated with long-term us...
Naoki Morito, Keigyou Yoh, Aki Hirayama, Ken Itoh, Masato Nose, Akio Koyama, Masayuki Yamamoto, Satoru Takahashi
Kidney International   65(5) 1703-13   May 2004
Background. Nrf2 is a basic leucine zipper transcriptional activator essential for the coordinate transcriptional induction of antioxidant and phase II drug metabolizing enzymes. We previously reported that Nrf2-deficient female mice develop lupus...
Naoki Morito, Keigyou Yoh, Ken Itoh, Ken Itoh, Aki Hirayama, Akio Koyama, Masayuki Yamamoto, Masayuki Yamamoto, Satoru Takahashi, Satoru Takahashi
Oncogene   22(58) 9274-9281   Dec 2003
Nrf2 is a basic leucine zipper transcriptional activator that is essential for the coordinate transcriptional induction of various antioxidant drug-metabolizing enzymes. Numerous studies have firmly established Nrf2's importance in protection from...
Aki Hirayama, Aki Hirayama, Sohji Nagase, Atsushi Ueda, Takashi Ishizu, Yoshinori Taru, Keigyou Yoh, Kouichi Hirayama, Masaki Kobayashi, Akio Koyama
Journal of Clinical Apheresis   18 18(2) 61-66-66   Aug 2003
Leukocyte absorption apheresis absorbs leukocytes to the apheresis columns involving leukocyte activation. This process is regarded as bioincompatible and avoided in hemodialysis or other extracorporeal circulation processes. Thus, leukocyte apher...
J. Usui, K. Kanemoto, S. Tomari, Y. Shu, K. Yoh, K. Mase, A. Hirayama, K. Hirayama, K. Yamagata, S. Nagase, M. Kobayashi, K. Nitta, S. Horita, A. Koyama, Michio Nagata, Michio Nagata
Histopathology   43 43(2):173-179-179   Aug 2003
Aims: To investigate the expression of the cadherin complex in human crescentic glomerulonephritis to elucidate the role of intercellular adherens junction molecules in crescent formation. Methods and results: Immunostaining revealed cadherin comp...
Aki Hirayama, Aki Hirayama, Keigyou Yoh, Sohji Nagase, Atsushi Ueda, Ken Itoh, Ken Itoh, Naoki Morito, Naoki Morito, Kouichi Hirayama, Satoru Takahashi, Masayuki Yamamoto, Masayuki Yamamoto, Akio Koyama
Free Radical Biology and Medicine   34(10) 1236-1242   May 2003
Mice that lack the Nrf2 (NF-E2-related factor 2) transcription factor develop a lupus-like autoimmune nephritis. The tissue-reducing activity of Nrf2-deficient mice was evaluated using a combination of real-time EPR imaging and spin probe kinetic ...
Kazumi Masuda, Kai Tanabe, Shinya Kuno, Aki Hirayama, Sohji Nagase
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology   134(134(2)) 215-220   Feb 2003
The amount of radical scavenging activity in muscle is unknown. The present study examines whether electron spin resonance (ESR) could measure and distinguish antioxidant capacity in muscle with different contractile and metabolic characteristics....
Atsushi Ueda, Sohji Nagase, Hidekatsu Yokoyama, Mika Tada, Hiroyuki Noda, Hiroaki Ohya, Hitoshi Kamada, Aki Hirayama, Akio Koyama
Molecular and Cellular Biochemistry   244(244(1)) 113-118   Feb 2003
Spin probing methods using an electron spin resonance (ESR) spectrometer are used extensively and bring us a lot of information about in vivo redox mechanisms. However, the in vivo reducing mechanisms of exogenous nitroxide radicals, which serve a...
Sohji Nagase, Hiromichi Suzuki, Ying Wang, Shuichi Kikuchi, Aki Hirayama, Atsushi Ueda, Kenji Takada, Takaaki Oteki, Mami Obara, Kazumasa Aoyagi, Akio Koyama
Molecular and Cellular Biochemistry   244(244(1)) 119-124   Feb 2003
Nitric oxide (NO) is a very potent regulator of intrarenal hemodynamics and is thought to be an important factor in the deterioration of renal function. Several polymorphisms of the endothelial NO synthase (eNOS) gene have been reported. For insta...
Aki Hirayama, Sohji Nagase, Atsushi Ueda, Atsushi Ueda, Keigyou Yoh, Takaaki Oteki, Mami Obara, Kenji Takada, Yukari Shimozawa, Kazumasa Aoyagi, Akio Koyama
Molecular and Cellular Biochemistry   244(1-2) 63-67   Feb 2003
The recent development of electron paramagnetic resonance (EPR) permits its application for in vivo studies of nitric oxide (NO). In this study, we tried to obtain 3D EPR images of endogenous NO in the abdominal organs of lipopolysuccaride (LPS) t...
Kazumasa Aoyagi, Yutaka Kuzure, Siranoush Shahrzad, Aki Hirayama, Sohji Nagase, Atsushi Ueda
Molecular and Cellular Biochemistry   244(1-2) 3-9   Feb 2003
Heparin has been reported to have many actions similar to calcium-dependent protein kinase (PKC) inhibitors. We have found that puromycin aminonucleoside (PAN) increases hydroxyl radical generation and this was prevented by H-7, a PKC inhibitor in...
Aki Hirayama, Sohji Nagase, Michihiro Gotoh, Atsushi Ueda, Takashi Ishizu, Keigyou Yoh, Kazumasa Aoyagi, Junji Terao, Akio Koyama
Free Radical Research   36 36(11):1155-1161-1161   Nov 2002
Relation between anemia resistant to recombinant human erythropoietin (rHuEPO) therapy and the oxidative stress in hemodialysis (HD) patients was investigated. Stable HD patients who had consistent hemoglobin concentrations on a constant dose of r...
Atsushi Ueda, Atsushi Ueda, Hidekatsu Yokoyama, Sohji Nagase, Sohji Nagase, Aki Hirayama, Akio Koyama, Hiroaki Ohya, Hitoshi Kamada
Magnetic Resonance Imaging   20 20:77-82-82   Apr 2002
The kinetics of a nitroxide radical in the renal parenchyma and pelvis in rats were investigated by employing an in vivo EPR imaging system equipped with a surface-coil-type resonator (SCR). The exposed kidney of a living rat was inserted into the...
K. Aoyagi, S. Shahrzad, S. Iida, C. Tomida, A. Hirayama, S. Nagase, K. Takemura, A. Koyama, S. Ohba, M. Narita, B. D. Cohen
Kidney International, Supplement   59 59 Suppl. 78; S93-96.   Jan 2001
Background. We propose that reactive oxygen and argininosuccinic acid (ASA) form guanidinosuccinic acid (GSA). An alternative to this hypothesis is the so-called guanidine cycle, which consists of a series of hydroxyurea derivatives that serve as ...
Keigyou Yoh, Keigyou Yoh, Keigyou Yoh, Keigyou Yoh, Ken Itoh, Ken Itoh, Ken Itoh, Ken Itoh, Akiko Enomoto, Akiko Enomoto, Akiko Enomoto, Akiko Enomoto, Aki Hirayama, Aki Hirayama, Aki Hirayama, Aki Hirayama, Naoto Yamaguchi, Naoto Yamaguchi, Naoto Yamaguchi, Naoto Yamaguchi, Masaki Kobayashi, Masaki Kobayashi, Masaki Kobayashi, Masaki Kobayashi, Naoki Morito, Naoki Morito, Naoki Morito, Naoki Morito, Akio Koyama, Akio Koyama, Akio Koyama, Akio Koyama, Masayuki Yamamoto, Masayuki Yamamoto, Masayuki Yamamoto, Masayuki Yamamoto, Satoru Takahashi, Satoru Takahashi, Satoru Takahashi, Satoru Takahashi
Kidney International   60(60(4)) 1343-1353   Jan 2001
Background: NF-E2-related factor 2 (Nrf2) is a basic leucine zipper transcriptional activator essential for the coordinate transcriptional induction of antioxidant enzymes and phase II drug metabolizing enzymes through the antioxidant response ele...
Aki Hirayama, Aki Hirayama, Sohji Nagase, Michihiro Gotoh, Katsumi Takemura, Chie Tomida, Atsushi Ueda, Kazumasa Aoyagi, Junji Terao, Akio Koyama
Nephron   86 86: 436-440.-440   Dec 2000
Hemodialysis (HD) patients are exposed to high oxidative stress, however, the nature of this stress is still unclear. In this study, we employed a specific lipid peroxidative product, phosphatidylcholine hydroperoxide (PCOOH), and evaluated the pe...
Inhibition of neutrophil superoxide production by uraemic concentrations of guanidino compounds. (共著)
Journal of the American Society of Nephrology   11 684-689   2000
Mamiya T, Katsuoka F, Hosoya T, Hirayama A, Kobayashi A, Maher J, Matsui H, Hyodo I, Yamamoto M.
Tohoku J Exp Med.   216(4) 331-339   2008
Kazumasa Aoyagi, Kayo Akiyama, Siranoush Shahrzad, Chie Tomida, Aki Hirayama, Sohji Nagase, Katsumi Takemura, Akio Koyama, Shoji Ohba, Mitsuharu Narita
Free Radical Research   31(1) 31(1):59-65-65   Sep 1999
Guanidinosuccinic acid (GSA) is noted for its nitric oxide (NO) mimicking actions such as vasodilatation and activation of the N-methyl-D-aspartate (NMDA) receptor. We have reported that GSA is the product of argininosuccinate (ASA) and some react...
K. Aoyagi, K. Akiyama, C. Tomida, M. Gotoh, A. Hirayama, K. Takemura, A. Ueda, S. Nagase, A. Koyama, M. Narita
Kidney International, Supplement   56 56 Suppl. 71:S153-5   Jan 1999
Background. To determine the locus of the increased oxidation induced by puromycin aminonucleoside (PAN), we imaged hydroperoxides in glomeruli stimulated by PAN in vivo and in vitro. Methods. Dichlorofluorescein diacetate (DCFH-DA) in cells makes...
Katsumi Takemura, Katsumi Takemura, Kazumasa Aoyagi, Sohji Nagase, Michihiro Gotoh, Aki Hirayama, Atsushi Ueda, Chie Tomida, Akio Koyama
Nephron   78 78: 82-87-87   Jan 1998
A state of peroxidation is one of the factors contributing to uremia. For example, we have reported that certain species of reactive oxygen, particularly the hydroxyl radical, play an important role in the biosynthesis of methylguanidine which con...
Sohji Nagase, Sohji Nagase, Kazumasa Aoyagi, Aki Hirayama, Michihiro Gotoh, Atsushi Ueda, Chie Tomida, Takao Kamezaki, Yasushi Nagai, Hiroshi Kikuchi, Akio Koyama
Journal of the American Society of Nephrology   8 8 : 1157-1163-1163   Jul 1997
There is considerable evidence that uremic patients are in a highly peroxidative state. The purpose of this study was to investigate the serum antioxidant activity that may regulate, or represent, the redox state in vivo. Serum from pre- and posth...
Sohji Nagase, Sohji Nagase, Katsumi Takemura, Atsushi Ueda, Aki Hirayama, Kazumasa Aoyagi, Makoto Kondoh, Akio Koyama
Biochemical and Biophysical Research Communications   233(1) 233 : 150-153-153   Apr 1997
Nitric oxide (NO) is a biologically active molecule known to be enzymatically synthesized from L-arginine in the presence of NO synthetase (NOS). In this study, we demonstrate a novel non-enzymatic pathway for NO synthesis involving hydrogen perox...
M. Gotoh, S. Nagase, S. Nagase, K. Aoyagi, A. Hirayama, K. Takemura, A. Ueda, C. Tomida, H. Kikuchi, A. Koyama
Nephrology Dialysis Transplantation   12 12 : 713 717-717   Apr 1997
Background: Patients with end-stage renal disease are thought to be in a highly peroxidative state, based on studies showing decreased serum antioxidant activity and increased peroxidative products. In this study we confirm these findings by exami...
NO is not exclusively generated by the reaction of L-Arginine and NOS, and is poorly idenitified by the Griess reaction of Clark type electrodes. (共著)
Nephron   77 489   1997
Favorable effect of hemodialysis on decreased serum antioxidant activity in hemodialysis patients demonstrated by electron spin resonance. (共著)
Journal of the American Society of Nephrology   8 1157-1163   1997
Kazumasa Aoyagi, Kazumasa Aoyagi, Sohji Nagase, Michihiro Gotoh, Kayo Akiyama, Makiko Satoh, Aki Hirayama, Akio Koyama
Enzyme and Protein   49 49 : 199-204.-211   Dec 1996
The synthesis of guanidinosuccinic acid (GSA) increases in uremics, and GSA is implicated as a uremic toxin. The GSA synthesis increases roughly in proportion to the serum urea level that increases in patients with renal failure. Urea is a specifi...
Sohji Nagase, Sohji Nagase, Kazumasa Aoyagi, Aki Hirayama, Michihiro Gotoh, Atsushi Ueda, Chie Tomida, Hiroshi Kikuchi, Katsumi Takemura, Akio Koyama
Nephron   74 74 : 555-560-560   Nov 1996
This study aims to raise the possibility of methylguanidine, a peroxidative product of creatinine, as a measure of the peroxidative state. As a known standard, we measured the inhibitory effect of uremic serum on the NADPH-dependent microsomal lip...
Sohji Nagase, Sohji Nagase, Kazumasa Aoyagi, Michihiro Gotoh, Aki Hirayama, Chie Tomida, Yukari Shimozawa, Akio Koyama
Nephron   74 74 : 204-208.-208   Sep 1996
This study investigated the peroxidative state of renal failure by measuring lipid peroxidation. The generation of lipid peroxides by rat hepatic microsomes was compared between experimental renal failure caused by 7/8 nephrectomy and healthy cont...
Role of reactive oxygen and argininosuccinate in guanidinosuccinate synthesis in isolated rat hepatocytes. (共著)
Enzyme and Protein   49 199-204   1996
Decreased serum antioxidant activity of hemodialysis patients demonstrated by methylguanidine synthesis and microsomal Lipid peroxidation. (共著)
Nephron   74 555-560   1996
Increased lipid peroxidation by rat liver microsomes in experimental renal failure. (共著)
Nephron   74 204-208   1996
Role of nitric oxide in the synthesis of guanidinosuccinic acid, an activator of the N-methyl-D-aspartate receptor.(共著)
Kidney Int.   59(Suppl. 78) S93-S96   2001
Imaging of hydroperoxides in a rat glomerulus stimulated by puromycin aminonucleoside. (共著)
Kidney Int   71 S153-5   1999
Oral administration of proanthocyanidin elevates radical scavenging activity in plasma and muscle tissue in rat.
Applied Physiology, Nutrition and Metabolism   in press    2007
Case of superantigen-related glomerulonephritis after Methicillin-resistant Staphylococcus aureus (MRSA) infection. (共著)
Clinical Nephrology   48 311-316   1997
Nitric Oxide from Inducible Nitric-Oxide Synthase Does not Exacerbate Adriamycin-Induced Tubulointerstitial Injury.
Medimond International Proceedings.The Proceedings of the XIII Congress of the Society for Free Radical Research International.   273-277   2006
Application of EPR Imaging to the Pathophysiological Analysis of Acute Renal Failure and Antioxidative Effects of Erythropoietin.
Medimond S.r.l.- Monduzzi Editore. Bologna, Italy.The Proceedings of the 12th Biennial Meeting of the Society for Free Radical Research International.      2005
Elimination of Cholesterylester Hydroperoxide during Hemodialysis.
Journal of the American Society of Nephrology   13 418A   2002
Nitric oxide from inducible nitric-oxide synthase does not exacerbate adriamycin-induced tubulointerstitial injury
FREE RADICAL RESEARCH   40(suppl 1) S59-S59   2006
Renal redox imaging and in vivo analysis during antihypertensive treatments
NEPHROLOGY DIALYSIS TRANSPLANTATION   21(Suppl. 4) 41-42   2006
Oxidative stress caused by intravenous iron administration in hemodialysis patients
NEPHROLOGY DIALYSIS TRANSPLANTATION   20(Suppl. 5) V276-V276   2005
Enhancement of NO and O-2(-) production in streptozotocin treated NRF2-deficient mice
NITRIC OXIDE-BIOLOGY AND CHEMISTRY   11(1) 52   2005

Books etc

 
EVALUATION OF ANTIOXIDANT ACTIVITY OF SERUM FROM HEMODIALYSIS PATIENTS USING ELECTRON SPIN RESONANCE(共著)
2000   
Involvment of a non-enzymatic nitric oxide generation pathway in hemodialysis patients. Guanidino Compounds in Biology and Medicine 5, (共著)
Blackwell Science Japan   1999   
Non-enzymatic generation of nitric oxide and an unreliability of its measurement by Greiss reaction or electrochemical method. Guanidino Compounds in Biology and Medicine 5, (共著)
Blackwell Science Japan   1999   
Evaluation of serum creatol in hemodialysis patients. Guanidino Compounds in Biology and Medicine5, (共著)
Blackwell Science Japan   1999   
Nitric oxide derived from guanidinoscuccinic acid, a stable nitric oxide mimic, from arginonosuccinic acid. Guanidino Compounds in Biology and Medicine 5, (共著)
Blackwell Science Japan   1999   

Works

 
S-nitrosothiols are stored by platelets and released during platelet-neutrophil interaction
1996 - 1997
Inhibition of neutrophil superoxide production by uraemic concentrations of guanidino compounds.
1996 - 1998
Hemodialysis does not influence the peroxidative state already present in uremia.
1995 - 2000

Research Grants & Projects

 
Pathophysiological analysis and clinical applications of reactive oxygen and nitrogen species in renal diseases.
In vivo measurement and imaging of free radicals using electron spin resonance