2022年12月1日
Association Between Alberta Stroke Program Early Computed Tomography Score and Efficacy and Safety Outcomes With Endovascular Therapy in Patients With Stroke From Large-Vessel Occlusion: A Secondary Analysis of the Recovery by Endovascular Salvage for Cer
JAMA neurology
- 巻
- 79
- 号
- 12
- 開始ページ
- 1260
- 終了ページ
- 1266
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1001/jamaneurol.2022.3285
[IMPORTANCE] Endovascular therapy (EVT) has been found to reduce functional disability in patients with acute stroke due to large-vessel occlusion. However, the extent of the ischemic region, measured using Alberta Stroke Program Early Computed Tomography Scores, may limit the efficacy of EVT.
[OBJECTIVE] To compare the efficacy and safety of EVT according to ASPECTS 3 or less vs 4 to 5.
[DESIGN, SETTING, AND PARTICIPANTS] The Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism-Japan Large Ischemic Core Trial (RESCUE-Japan LIMIT) was an open-label randomized clinical trial conducted from November 2018 to December 2021 at 45 stroke centers across Japan. The trial enrolled adult patients with acute ischemic stroke with a large ischemic region, defined as ASPECTS 3 to 5 primarily determined by magnetic resonance imaging, with occlusion site at the internal carotid artery or middle cerebral artery segment 1. Among 203 enrolled patients, 1 withdrew consent and 202 were included in the original trial and secondary analysis. This secondary analysis was conducted in April 2022.
[INTERVENTIONS] Patients were randomly assigned to EVT with medical therapy or medical therapy alo
[OBJECTIVE] To compare the efficacy and safety of EVT according to ASPECTS 3 or less vs 4 to 5.
[DESIGN, SETTING, AND PARTICIPANTS] The Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism-Japan Large Ischemic Core Trial (RESCUE-Japan LIMIT) was an open-label randomized clinical trial conducted from November 2018 to December 2021 at 45 stroke centers across Japan. The trial enrolled adult patients with acute ischemic stroke with a large ischemic region, defined as ASPECTS 3 to 5 primarily determined by magnetic resonance imaging, with occlusion site at the internal carotid artery or middle cerebral artery segment 1. Among 203 enrolled patients, 1 withdrew consent and 202 were included in the original trial and secondary analysis. This secondary analysis was conducted in April 2022.
[INTERVENTIONS] Patients were randomly assigned to EVT with medical therapy or medical therapy alo
- リンク情報
- ID情報
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- DOI : 10.1001/jamaneurol.2022.3285
- ISSN : 2168-6157
- PubMed ID : 36215044
- PubMed Central 記事ID : PMC9552045